sepsis — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T40423	L48H37
	L48H37 is a chemically stable analog of Curcumin. It exhibits potent inhibitory properties against myeloid differentiation protein 2 (MD2), acting as a specific inhibitor. Its mechanism involves inhibiting the interactio...
T10831L	Cl-amidine hydrochloride		Apoptosis , PAD
	Cl-amidine hydrochloride is an orally active peptidylarginine deminase (PAD) inhibitor (IC50: 5.9 μM for PAD4). Cl-amidine hydrochloride induces apoptosis in cancer cells and it also induces microRNA (miR)-16 in vitro ca...		Apoptosis , PAD
TN1039	Tamarixetin	4'-O-Methyl Quercetin	Endogenous Metabolite , Immunology/Inflammation related
	Tamarixetin (4'-O-Methyl Quercetin) (4'-O-Methyl Quercetin) is a natural flavonoid derivative of quercetin, with anti-inflammatory and anti-oxidative effects. Tamarixetin protects against cardiac hypertrophy.		Endogenous Metabolite , Immunology/Inflammation related
T4989	Fosfomycin Tromethamine		Antibacterial , Antibiotic
	An antibiotic produced by Streptomyces fradiae.		Antibacterial , Antibiotic
T1221	Acetylcholine chloride	ACh chloride,Pilofrin	Calcium Channel , Endogenous Metabolite , AChR
	Acetylcholine Chloride is the chloride salt form of acetylcholine, a synthetic, quaternary amino alcohol with cholinergic properties. Acetylcholine chloride (Pilofrin) mimics the parasympathomimetic effect of the endogen...		Calcium Channel , Endogenous Metabolite , AChR
T1001	Dicloxacillin Sodium hydrate	Dicloxacillin sodium salt monohydrate,Dicloxacillin sodium monohydrate	Antibacterial , Antibiotic
	Dicloxacillin Sodium hydrate is a narrow-spectrum β-Lactam antibiotic of the penicillin class, used to treat infections caused by susceptible Gram-positive bacteria.		Antibacterial , Antibiotic
T3131	Fosfomycin calcium	Phosphomycin calcium salt,Fosmicin	Antibacterial , Antibiotic
	Fosfomycin calcium (Phosphomycin calcium salt) is a blood-brain barrier penetrating, broad-spectrum antibiotic by irreversibly inhibiting an early stage in cell wall synthesis.		Antibacterial , Antibiotic
T8262	Fosfomycin sodium	Fosfomycin Disodium	Antibacterial , Antibiotic
	Fosfomycin sodium is a bactericidal, low-molecular weight, broad-spectrum antibiotic, with putative activity against several bacteria, including multidrug-resistant Gram-negative bacteria, by irreversibly inhibiting an e...		Antibacterial , Antibiotic
T9543	Syk Inhibitor II hydrochloride		Others
	The impact of spleen tyrosine kinase (Syk) signaling might be prominent in lupus because (i) Syk is a shared downstream signaling molecule among circulating immune complex, LPS, and (1→3)-β-D-glucan (BG), and (ii) all of...		Others
T12242	Norvancomycin hydrochloride	Desmethyl-vancomycin hydrochloride	Antibacterial
	Norvancomycin hydrochloride (Desmethyl-vancomycin hydrochloride) is used as a treatment for endocarditis, osteomyelitis, pneumonia, sepsis, or soft tissue infections caused by Staphylococcus.		Antibacterial
TN1594	DL-Syringaresinol	(±)-Syringaresinol	Antioxidant , Antifungal
	DL-Syringaresinol ( (±)-Syringaresinol) is a lignan from ginseng berries with anti-inflammatory, antioxidant, analgesic and weak anti-mycobacterial activities.DL-Syringaresinol can delay oxidative stress-induced skin agi...		Antioxidant , Antifungal
TN6926	Paeonoside		Others
	Paeonoside, found in P. suffruticosa, is biologically active and can promote wound healing and migration during osteoblast differentiation. Paeonoside has certain antidiabetic activity and may prevent sepsis and death fr...		Others
T8134	Cefathiamidine		Antibacterial , Antibiotic
	Cefathiamidine exhibits a wide spectrum of antimicrobial activity against bacteria. Cefathiamidine is used for the treatment of respiratory, liver, five senses, urinary tract infections, endocarditis and sepsis		Antibacterial , Antibiotic
T74398	DATPT		Reactive Oxygen Species , Antibacterial
	DATPT is a small molecule 12WLVSKF17 peptide mimetic molecule.DATPT inhibits SNX9-p47phox interactions and inhibits the production of reactive oxygen species and inflammatory cytokines.DATPT has anti-inflammatory and ant...		Reactive Oxygen Species , Antibacterial
T5S0167	Atractylenolide I		IL Receptor , TNF , TLR , JAK , STAT
	1. Atractylenolide-I has an anti-inflammatory effect by inhibiting TNF-α and IL-6 production; ameliorates sepsis syndrome, liver and kidney functions by reduction of pro-inflammatory cytokines and LPS. 2. Atractylenolide...		IL Receptor , TNF , TLR , JAK , STAT
T67965	Torbafylline		cAMP , PI3K , PDE
	Torbafylline, a xanthine derivative, is a phosphodiesterase (PDE) inhibitor that attenuates burn-induced protein hydrolysis in rat skeletal muscle through activation of the PDE4/cAMP/EPAC/PI3K/Akt pathway, and inhibits t...		cAMP , PI3K , PDE
TN6774	Emodin 6-O-β-D-glucoside	Glucoemodin	Others
	Emodin 6-O-β-D-glucoside (Glucoemodin) can protect barrier integrity and inhibit HMGB1-mediated inflammatory responses, which suggests a potential use as a therapy for sepsis or septic shock. Emodin 6-O-beta-D-glucoside ...		Others
T76662	Ac-Pro-Gly-Pro-OH		Apoptosis , CXCR , Antibiotic
	Ac-Pro-Gly-Pro-OH is an acetyl-modified tripeptide compound that acts as a CXCR2 agonist.Ac-Pro-Gly-Pro-OH exhibits bactericidal and anti-inflammatory activity, inhibits apoptosis of immune cells, and suppresses the prod...		Apoptosis , CXCR , Antibiotic
T0186	Docetaxel trihydrate	RP-56976 (Trihydrate),RP56976 (NSC 628503) Trihydrate	Apoptosis , BCL , Microtubule Associated
	Docetaxel trihydrate (RP-56976 Trihydrate) is an antineoplastic agent that has a unique mechanism of action as an inhibitor of cellular mitosis and that currently plays a central role in the therapy of many solid tumor i...		Apoptosis , BCL , Microtubule Associated
T74485	STC314		Others
	STC314 is an anti-infective agent that reverses organ damage caused by excessive immune response by neutralizing extracellular histones and neutrophil trapping networks, and can be used in the study of sepsis and acute r...		Others