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Syk Inhibitor II hydrochloride

Catalog No. T9543 CAS 2490508-82-0

The impact of spleen tyrosine kinase (Syk) signaling might be prominent in lupus because (i) Syk is a shared downstream signaling molecule among circulating immune complex, LPS, and (1→3)-β-D-glucan (BG), and (ii) all of these factors are detectable in the serum of Fc gamma receptor IIb-deficient (FcgRIIb-/-) mice with sepsis. Syk inhibition downregulated several inflammatory pathways in FcgRIIb-/- macrophages activated with BG + LPS suggesting the potential anti-inflammatory impact of Syk inhibitors in lupus. Indeed, administration of a Syk inhibitor prior to cecal ligation and puncture (CLP) sepsis in FcgRIIb-/- mice reduced baseline lupus-induced proinflammatory cytokines and attenuated sepsis severity as evaluated by mortality, organ injury, serum LPS, and post-sepsis serum cytokines.

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Syk Inhibitor II hydrochloride Chemical Structure

Syk Inhibitor II hydrochloride, CAS 2490508-82-0

Pack Size	Availability	Price/USD
1 mg	In stock	$ 34.00
5 mg	In stock	$ 71.00
10 mg	In stock	$ 133.00
25 mg	In stock	$ 227.00
50 mg	In stock	$ 356.00
100 mg	In stock	$ 570.00
1 mL * 10 mM (in DMSO)	In stock	$ 78.00

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Purity: 98.17%

Purity: 97.63%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Molecular Weight	376.77
Formula	C14H16ClF3N6O
CAS No.	2490508-82-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/mL (145.98 mM)

References and Literature

1. Issara-Amphorn et al. Syk Inhibitor Attenuates Polymicrobial Sepsis in FcgRIIb-Deficient Lupus Mouse Model, the Impact of Lupus Characteristics in Sepsis. J Innate Immun. 2020;12(6):461-479.

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Keywords

Syk Inhibitor II hydrochloride 2490508-82-0 Others Syk Inhibitor II Hydrochloride inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.