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Search Results for " receptor-related "

20

Compounds

Cat No. Product Name Synonyms Targets
T39250 Bevurogant ROR
Bevurogant is an antagonist of RORγt receptor and can be used in studies about the treatment of chronic inflammatory diseases.
T16832 S18-000003 ROR
S18-000003 is an effective orally bioavailable retinoic acid receptor-related orphan receptor-gamma-t inhibitor (IC50: 29 nM). S18-000003 inhibits IL-17 production.
T7568 LM22A-4 Trk receptor
LM22A-4 is a brain-derived neurotrophic factor (BDNF) mimetic and agonist of the receptor tropomyosin-related kinase B (TrkB; IC50 : 47 nM in a fluorescence anisotropy assay)
T14921 CE-245677 Tie-2 , Trk receptor
CE-245677 is a potent reversible inhibitor of Tie2 and TrkA/B kinases. With a cellular IC50s of 4.7 and 1 nM.
T5635 CH7057288 Trk receptor
CH7057288 is an effective and selective TRK inhibitor with an IC50 value of 1.1 nM, 7.8 nM and 5.1 nM for TRKA, TRKB and TRKC, respectively.
T3S1251 Neoruscogenin ROR
1. Neoruscogenin represents a universal pharmacological tool for RORα research due to its specific selectivity profile versus other nuclear receptors.
T6097 GNF-5837 GNF 5837 Trk receptor , PDGFR , c-Kit
GNF-5837 is a specific, and orally bioavailable pan-TRK inhibitor for TrkA/TrkB (IC50: 8/12 nM).
T14363 AZ-23 AZ 23,AZ23 Trk receptor
AZ-23 is an inhibitor of ATP-competitive and Trk kinase A/B/C. For TrkA, TrkB, FGFR1, Flt3, Ret, MuSk, Lck, the IC50s values are 2 nM, 8 nM, 24 nM, 52 nM, 55 nM, 84 nM, 99 nM, respectively.
T2359 ANA-12 ANA 12,ANA12 Trk receptor
ANA-12 is a potent and selective TrkB antagonist with anxiolytic and antidepressant activity in mice.
T7435 Selitrectinib LOXO-195 Trk receptor
Selitrectinib (LOXO-195) is a potent and selective inhibitor of the receptor tyrosine kinases(TRK)( TrkA and TrkC with IC50s of 0.6 and <2.5 nM, respectively)
T6052 GW 441756 Apoptosis , Raf , Trk receptor , CDK
GW 441756 is a specific Tropomyosin-related kinase A (TrkA) inhibitor with an IC50 value of 2 nM.
T17194 Ubrogepant MK-1602 CGRP Receptor
Ubrogepant (MK-1602) is an antagonist of calcitonin gene-related peptide receptor that can be used in the acute treatment of migraine studies.
T6S1597 Mulberroside A TNF , Tyrosinase , Interleukin
1. Mulberroside has nephroprotective, hypoglycemic, and antidiabetic effects. 2. Mulberroside A is a glycosylated stilbene of oxyresveratrol; thus, the deglycosylation of Mulberroside A resulted in enhanced inhibition of...
T4670 SR0987 ROR
SR0987 is a RORγt agonist,
T5163 SR1001 ROR
SR 1001 is an inverse agonist for RORα/RORγ (Kis: 172/111 nM).
T7904 SR 19881 Estrogen/progestogen Receptor
SR 19881 is a full agonist of ERRγ(EC50 value of 0.39 μM in a binding assay and an EC50 value of 4.7 μM in a cell-based assay).
T13375 YQ128 IL Receptor , NOD-like Receptor (NLR) , NOD , Interleukin
YQ128 is a potent and selective inhibitor of second-generation NLRP3 (NOD-like receptor P3) inflammasome(IC50 of 0.30 µM), with anti-inflammatory activity.
T4594 SR1078 SR 1078 ROR
SR1078 is an agonist of retinoic acid receptor-related orphan receptor (ROR)α/γ.
T3183 SAX-187 WAY 181187,WAY181187 5-HT Receptor
SAX-187 (SAX-187) has high-affinity binding at the human 5-HT6 receptor.
T9123 DS-1205 TAM Receptor
DS-1205 is a potent and selective inhibitor of AXL kinase, with an IC50 of 1.3 nM. DS-1205 also inhibits MER, MET, and TRKA, with IC50s of 63, 104, and 407 nM, respectively. DS-1205 can inhibit cell migration in vitro an...
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