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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T39250 | Bevurogant | ROR | |
Bevurogant is an antagonist of RORγt receptor and can be used in studies about the treatment of chronic inflammatory diseases. | |||
T16832 | S18-000003 | ROR | |
S18-000003 is an effective orally bioavailable retinoic acid receptor-related orphan receptor-gamma-t inhibitor (IC50: 29 nM). S18-000003 inhibits IL-17 production. | |||
T7568 | LM22A-4 | Trk receptor | |
LM22A-4 is a brain-derived neurotrophic factor (BDNF) mimetic and agonist of the receptor tropomyosin-related kinase B (TrkB; IC50 : 47 nM in a fluorescence anisotropy assay) | |||
T14921 | CE-245677 | Tie-2 , Trk receptor | |
CE-245677 is a potent reversible inhibitor of Tie2 and TrkA/B kinases. With a cellular IC50s of 4.7 and 1 nM. | |||
T5635 | CH7057288 | Trk receptor | |
CH7057288 is an effective and selective TRK inhibitor with an IC50 value of 1.1 nM, 7.8 nM and 5.1 nM for TRKA, TRKB and TRKC, respectively. | |||
T3S1251 | Neoruscogenin | ROR | |
1. Neoruscogenin represents a universal pharmacological tool for RORα research due to its specific selectivity profile versus other nuclear receptors. | |||
T6097 | GNF-5837 | GNF 5837 | Trk receptor , PDGFR , c-Kit |
GNF-5837 is a specific, and orally bioavailable pan-TRK inhibitor for TrkA/TrkB (IC50: 8/12 nM). | |||
T14363 | AZ-23 | AZ 23,AZ23 | Trk receptor |
AZ-23 is an inhibitor of ATP-competitive and Trk kinase A/B/C. For TrkA, TrkB, FGFR1, Flt3, Ret, MuSk, Lck, the IC50s values are 2 nM, 8 nM, 24 nM, 52 nM, 55 nM, 84 nM, 99 nM, respectively. | |||
T2359 | ANA-12 | ANA 12,ANA12 | Trk receptor |
ANA-12 is a potent and selective TrkB antagonist with anxiolytic and antidepressant activity in mice. | |||
T7435 | Selitrectinib | LOXO-195 | Trk receptor |
Selitrectinib (LOXO-195) is a potent and selective inhibitor of the receptor tyrosine kinases(TRK)( TrkA and TrkC with IC50s of 0.6 and <2.5 nM, respectively) | |||
T6052 | GW 441756 | Apoptosis , Raf , Trk receptor , CDK | |
GW 441756 is a specific Tropomyosin-related kinase A (TrkA) inhibitor with an IC50 value of 2 nM. | |||
T17194 | Ubrogepant | MK-1602 | CGRP Receptor |
Ubrogepant (MK-1602) is an antagonist of calcitonin gene-related peptide receptor that can be used in the acute treatment of migraine studies. | |||
T6S1597 | Mulberroside A | TNF , Tyrosinase , Interleukin | |
1. Mulberroside has nephroprotective, hypoglycemic, and antidiabetic effects. 2. Mulberroside A is a glycosylated stilbene of oxyresveratrol; thus, the deglycosylation of Mulberroside A resulted in enhanced inhibition of... | |||
T4670 | SR0987 | ROR | |
SR0987 is a RORγt agonist, | |||
T5163 | SR1001 | ROR | |
SR 1001 is an inverse agonist for RORα/RORγ (Kis: 172/111 nM). | |||
T7904 | SR 19881 | Estrogen/progestogen Receptor | |
SR 19881 is a full agonist of ERRγ(EC50 value of 0.39 μM in a binding assay and an EC50 value of 4.7 μM in a cell-based assay). | |||
T13375 | YQ128 | IL Receptor , NOD-like Receptor (NLR) , NOD , Interleukin | |
YQ128 is a potent and selective inhibitor of second-generation NLRP3 (NOD-like receptor P3) inflammasome(IC50 of 0.30 µM), with anti-inflammatory activity. | |||
T4594 | SR1078 | SR 1078 | ROR |
SR1078 is an agonist of retinoic acid receptor-related orphan receptor (ROR)α/γ. | |||
T3183 | SAX-187 | WAY 181187,WAY181187 | 5-HT Receptor |
SAX-187 (SAX-187) has high-affinity binding at the human 5-HT6 receptor. | |||
T9123 | DS-1205 | TAM Receptor | |
DS-1205 is a potent and selective inhibitor of AXL kinase, with an IC50 of 1.3 nM. DS-1205 also inhibits MER, MET, and TRKA, with IC50s of 63, 104, and 407 nM, respectively. DS-1205 can inhibit cell migration in vitro an... |