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Catalog No. T7568Cas No. 37988-18-4
LM22A-4 is a brain-derived neurotrophic factor (BDNF) mimetic and agonist of the receptor tropomyosin-related kinase B (TrkB; IC50 : 47 nM in a fluorescence anisotropy assay)
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Pack SizePriceAvailabilityQuantity
5 mg$39In Stock
10 mg$72In Stock
25 mg$155In Stock
50 mg$272In Stock
100 mg$478In Stock
500 mg$1,050In Stock
1 mL x 10 mM (in DMSO)$43In Stock
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Related Compound Libraries of "LM22A-4"

Product Introduction

LM22A-4 is a brain-derived neurotrophic factor (BDNF) mimetic and agonist of the receptor tropomyosin-related kinase B (TrkB; IC50 : 47 nM in a fluorescence anisotropy assay)
In vitro
In vitro, LM22A-4 increases survival of hippocampal neurons via activation of TrkB as well as Akt and ERK downstream pro-survival signaling pathways[1].
In vivo
Treatment of Het mice with LM22A-4 for 4 weeks rescued wild-type levels of TrkB phosphorylation in the medulla and pons and restored wild-type breathing frequency[1].
Animal Research
Wt and Het littermates were divided into 4 groups: Wt vehicle-treated (100 μl of 0.9% NaCl, i.p., b.i.d.), Wt drug-treated (50 mg/kg LM22A-4 in 0.9% NaCl, i.p., b.i.d.), Het vehicle-treated (100 μl of 0.9% NaCl, i.p., b.i.d.), and Het drug-treated (50 mg/kg LM22A-4 in 0.9% NaCl, i.p., b.i.d.).?Each mouse was treated from 8 to 13 weeks of age.?Whole-body plethysmography was performed during week 12 and animals were subsequently killed and tissues harvested for TrkB Western blots and BDNF ELISA during week[1].
Chemical Properties
Molecular Weight339.34
Cas No.37988-18-4
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
H2O: 50 mg/mL (147.34 mM)
DMSO: 29 mg/mL (85.46 mM)
Solution Preparation Table
1 mM2.9469 mL14.7345 mL29.4690 mL147.3448 mL
5 mM0.5894 mL2.9469 mL5.8938 mL29.4690 mL
10 mM0.2947 mL1.4734 mL2.9469 mL14.7345 mL
20 mM0.1473 mL0.7367 mL1.4734 mL7.3672 mL
50 mM0.0589 mL0.2947 mL0.5894 mL2.9469 mL
100 mM0.0295 mL0.1473 mL0.2947 mL1.4734 mL


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