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LM22A-4

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Purity:98%

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COA HNMR

LM22A-4

Catalog No. T7568Cas No. 37988-18-4

LM22A-4 is a brain-derived neurotrophic factor (BDNF) mimetic and agonist of the receptor tropomyosin-related kinase B (TrkB; IC50 : 47 nM in a fluorescence anisotropy assay)

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Pack Size	Price	Availability
5 mg	$39	In Stock
10 mg	$72	In Stock
25 mg	$155	In Stock
50 mg	$272	In Stock
100 mg	$478	In Stock
500 mg	$1,050	In Stock
1 mL x 10 mM (in DMSO)	$43	In Stock

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Product Introduction

Bioactivity

Description	LM22A-4 is a brain-derived neurotrophic factor (BDNF) mimetic and agonist of the receptor tropomyosin-related kinase B (TrkB; IC50 : 47 nM in a fluorescence anisotropy assay)
In vitro	In vitro, LM22A-4 increases survival of hippocampal neurons via activation of TrkB as well as Akt and ERK downstream pro-survival signaling pathways[1].
In vivo	Treatment of Het mice with LM22A-4 for 4 weeks rescued wild-type levels of TrkB phosphorylation in the medulla and pons and restored wild-type breathing frequency[1].
Animal Research	Wt and Het littermates were divided into 4 groups: Wt vehicle-treated (100 μl of 0.9% NaCl, i.p., b.i.d.), Wt drug-treated (50 mg/kg LM22A-4 in 0.9% NaCl, i.p., b.i.d.), Het vehicle-treated (100 μl of 0.9% NaCl, i.p., b.i.d.), and Het drug-treated (50 mg/kg LM22A-4 in 0.9% NaCl, i.p., b.i.d.).?Each mouse was treated from 8 to 13 weeks of age.?Whole-body plethysmography was performed during week 12 and animals were subsequently killed and tissues harvested for TrkB Western blots and BDNF ELISA during week[1].

Chemical Properties

Molecular Weight	339.34
Formula	C15H21N3O6
Cas No.	37988-18-4

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 50 mg/mL (147.34 mM)

DMSO: 45 mg/mL (132.61 mM), Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9469 mL	14.7345 mL	29.4690 mL	147.3448 mL
5 mM	0.5894 mL	2.9469 mL	5.8938 mL	29.4690 mL
10 mM	0.2947 mL	1.4734 mL	2.9469 mL	14.7345 mL
20 mM	0.1473 mL	0.7367 mL	1.4734 mL	7.3672 mL
50 mM	0.0589 mL	0.2947 mL	0.5894 mL	2.9469 mL
100 mM	0.0295 mL	0.1473 mL	0.2947 mL	1.4734 mL

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