Powder: -20°C for 3 years | In solvent: -80°C for 1 year
YQ128 is a potent and selective inhibitor of second-generation NLRP3 (NOD-like receptor P3) inflammasome(IC50 of 0.30 µM), with anti-inflammatory activity.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 51.00 | |
5 mg | In stock | $ 122.00 | |
10 mg | In stock | $ 197.00 | |
25 mg | In stock | $ 322.00 | |
50 mg | In stock | $ 538.00 | |
100 mg | In stock | $ 777.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 147.00 |
Description | YQ128 is a potent and selective inhibitor of second-generation NLRP3 (NOD-like receptor P3) inflammasome(IC50 of 0.30 µM), with anti-inflammatory activity. |
Targets&IC50 | IL-1β:, NLRP3:0.30 μM |
In vitro | The release of IL-1β from peritoneal macrophages upon LPS/ATP challenge(IC50 of 1.59 μM) dose dependently suppressed by YQ128 (0.3-100 μM; 30 mins). |
In vivo | YQ128 (oral; 20 mg/kg) shows delayed gastrointestinal absorption with a tmax and cmax of 12 h and 73 ng/mL, respectively. YQ128 exhibits extensive extravascular distribution with a large steady-state volume of distribution (Vdss) of 8.5 L/kg and rapid total clearance (CLtot) of 41 mL/min/kg. In C57BL/6 mice, YQ128 (10 mg/kg) has been shown to trigger IL-1β production in a NLRP3- dependent manner . |
Molecular Weight | 545.11 |
Formula | C27H29ClN2O4S2 |
CAS No. | 2454246-18-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 248 mg/mL (454.95 mM), Sonification is recommended.
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
YQ128 2454246-18-3 Immunology/Inflammation NF-Κb IL Receptor NOD-like Receptor (NLR) NOD Interleukin inhibit Inhibitor Interleukin Related YQ 128 YQ-128 inhibitor