Powder: -20°C for 3 years
In solvent: -80°C for 2 years
YQ128 is a potent and selective inhibitor of second-generation NLRP3 (NOD-like receptor P3) inflammasome(IC50 of 0.30 µM), with anti-inflammatory activity.
Description | YQ128 is a potent and selective inhibitor of second-generation NLRP3 (NOD-like receptor P3) inflammasome(IC50 of 0.30 µM), with anti-inflammatory activity. |
Targets&IC50 | NLRP3:0.30 μM, IL-1β: |
In vitro | The release of IL-1β from peritoneal macrophages upon LPS/ATP challenge(IC50 of 1.59 μM) dose dependently suppressed by YQ128 (0.3-100 μM; 30 mins). |
In vivo | YQ128 (oral; 20 mg/kg) shows delayed gastrointestinal absorption with a tmax and cmax of 12 h and 73 ng/mL, respectively. YQ128 exhibits extensive extravascular distribution with a large steady-state volume of distribution (Vdss) of 8.5 L/kg and rapid total clearance (CLtot) of 41 mL/min/kg. In C57BL/6 mice, YQ128 (10 mg/kg) has been shown to trigger IL-1β production in a NLRP3- dependent manner . |
Molecular Weight | 545.11 |
Formula | C27H29ClN2O4S2 |
CAS No. | 2454246-18-3 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: 248 mg/mL (454.95 mM), Need ultrasonic
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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YQ128 2454246-18-3 NF-Kb信号通路 免疫与炎症 IL Receptor Interleukin NOD NOD-like Receptor (NLR) inhibit YQ 128 Inhibitor Interleukin Related YQ-128 inhibitor