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YQ128

YQ128
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Purity:99.67%
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YQ128

Catalog No. T13375Cas No. 2454246-18-3
YQ128 is a potent and selective inhibitor of second-generation NLRP3 (NOD-like receptor P3) inflammasome(IC50 of 0.30 µM), with anti-inflammatory activity.
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Pack SizePrice/USDAvailabilityQuantity
1 mg$51In Stock
5 mg$122In Stock
10 mg$197In Stock
25 mg$322In Stock
50 mg$538In Stock
100 mg$777In Stock
1 mL x 10 mM (in DMSO)$147In Stock
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Product Introduction

Bioactivity
Description
YQ128 is a potent and selective inhibitor of second-generation NLRP3 (NOD-like receptor P3) inflammasome(IC50 of 0.30 µM), with anti-inflammatory activity.
In vitro
The release of IL-1β from peritoneal macrophages upon LPS/ATP challenge(IC50 of 1.59 μM) dose dependently suppressed by YQ128 (0.3-100 μM; 30 mins).
In vivo
YQ128 (oral; 20 mg/kg) shows delayed gastrointestinal absorption with a tmax and cmax of 12 h and 73 ng/mL, respectively. YQ128 exhibits extensive extravascular distribution with a large steady-state volume of distribution (Vdss) of 8.5 L/kg and rapid total clearance (CLtot) of 41 mL/min/kg. In C57BL/6 mice, YQ128 (10 mg/kg) has been shown to trigger IL-1β production in a NLRP3- dependent manner .
Chemical Properties
Molecular Weight545.11
FormulaC27H29ClN2O4S2
Cas No.2454246-18-3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: 248 mg/mL (454.95 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.8345 mL9.1725 mL18.3449 mL91.7246 mL
5 mM0.3669 mL1.8345 mL3.6690 mL18.3449 mL
10 mM0.1834 mL0.9172 mL1.8345 mL9.1725 mL
20 mM0.0917 mL0.4586 mL0.9172 mL4.5862 mL
50 mM0.0367 mL0.1834 mL0.3669 mL1.8345 mL
100 mM0.0183 mL0.0917 mL0.1834 mL0.9172 mL

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