reabsorption — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T15160	Dotinurad	(3,5-dichloro-4-hydroxyphenyl)(1,1-dioxidobenzo[d]thiazol-3(2H)-yl)methanone	OAT
	Dotinurad ((3,5-dichloro-4-hydroxyphenyl)(1,1-dioxidobenzo[d]thiazol-3(2H)-yl)methanone) is a potent agent of uricosuric (IC50: 3.6 μM for uric acid).		OAT
T9590	T-1095		SGLT , transporter
	T-1095 is an inhibitor of renal glucose reabsorption and the expression of Na+-glucose cotransporters (SGLTs) and facilitative glucose transporter 2 (GLUT2).		SGLT , transporter
T35371	Colesevelam Hydrochloride		Others
	Colesevelam Hydrochloride is a bile acid sequestrant with a higher affinity for glycocholic acid in vitro. Colesevelam Hydrochloride inhibits bile acid reabsorption, leading to increased bile acid synthesis and reduces c...		Others
T60561	Disulfamide		Carbonic Anhydrase
	Disulfamide is an orally active carbonic anhydrase inhibitor with an IC50 value of 0.07 μM. Disulfamide has a diuretic effect by inhibiting carbonic anhydrase and preventing the reabsorption of sodium and bicarbonate in ...		Carbonic Anhydrase
T3268	Mildronate	Kvaterin,Meldonium,Quaterin	Hydroxylase
	Mildronate (Meldonium) is an inhibitor of biosynthesis of L-carnitine by gamma-butyrobetaine (GBB) hydroxylase and as a competitive inhibitor of renal carnitine reabsorption.		Hydroxylase
T0114	Trichlormethiazide	Naqua,Metahydrin,Trichlormetazid	ATPase , Carbonic Anhydrase
	Trichlormethiazide (Naqua) is a short-acting, 3-dichloromethyl derivative of hydrochlorothiazide, belonging to the class of thiazide diuretics. Trichlormethiazide appears to block the active reabsorption of chloride and ...		ATPase , Carbonic Anhydrase
T6875	Lesinurad	RDEA594	OAT
	Lesinurad (RDEA594) is a selective inhibitor of uric acid reabsorption which is used in combination with other agents in the therapy of gout. Lesinurad has had a limited clinical use but has not been associated with seru...		OAT
T24415	Lotrifen	Privaprol,L-12717,DL 717-IT,L 12717,L12717,Canocenta	Others
	Lotrifen (Privaprol), an agent of non-hormonal antifertility, causes the arrest and involution of pregnancy. It acts, after the implantation of the blastocyst, directly on the product of conception, which undergoes a slo...		Others
T1782L	Canagliflozin hemihydrate	JNJ28431754,TA 7284,TA7284,TA-7284,JNJ 28431754,JNJ-28431754	SGLT
	Canagliflozin hemihydrate (TA 7284) is a drug of the gliflozin class or subtype 2 sodium-glucose transport inhibitors used for the treatment of type 2 diabetes. SGLT2 is responsible for at least 90% of renal glucose reab...		SGLT
T5019	Desmopressin	DDAVP,Desmopressin Acetate	Vasopressin Receptor
	Desmopressin (DDAVP)(DDAVP) is the synthetic analogue of the antidiuretic hormone arginine vasopressin.Vasopressin Receptor The antidiuretic properties of desmopressin have led to its use in polyuric conditions including...		Vasopressin Receptor
T0869	Atomoxetine hydrochloride	Tomoxetine hydrochloride,(R)-Tomoxetine hydrochloride,LY 139603,Atomoxetine HCl,LY 139603 HCl	Dopamine Receptor , 5-HT Receptor , Norepinephrine
	Atomoxetine hydrochloride (LY 139603) is the hydrochloride salt of atomoxetine, a phenoxy-3-propylamine derivative and selective non-stimulant, norepinephrine reuptake inhibitor with cognitive-enhancing activity. Althou...		Dopamine Receptor , 5-HT Receptor , Norepinephrine
TJS0387	Desoxyrhaponticin	Deoxyrhapontin,Deoxyrhaponticin	Apoptosis , Fatty Acid Synthase
	1. Desoxyrhaponticin (Deoxyrhaponticin) is an agent that is potentially effective in controlling postprandial hyperglycemia in diabetes, the in vivo antidiabetic action of this compound can be explained, in part at least...		Apoptosis , Fatty Acid Synthase
T4460	Dapagliflozin ((2S)-1,2-propanediol, hydrate)	BMS-512148 (2S)-1,2-propanediol, hydrate,Dapagliflozin propanediol monohydrate	SGLT
	Dapagliflozin ((2S)-1,2-propanediol, hydrate) (BMS-512148 (2S)-1,2-propanediol, hydrate) is a selective, orally active inhibitor of the renal sodium-glucose co-transporter type 2 (SGLT2). It is in development for the tre...		SGLT
T5144	Desmopressin acetate (16679-58-6 free base)	Desmopressin acetate,DDAVP	Vasopressin Receptor
	Desmopressin acetate (16679-58-6 free base) (DDAVP) is the synthetic analog of the antidiuretic hormone arginine vasopressin. Vasopressin Receptor The antidiuretic properties of desmopressin have led to its use in polyur...		Vasopressin Receptor
T1666	Fludrocortisone acetate	9α-Fluorcortisol acetate,9α-Fludrocortisone acetate,9α-fluorocortisol acetate	Glucocorticoid Receptor , Autophagy
	Fludrocortisone acetate (9α-Fludrocortisone acetate) , a glucocorticoid-receptor agonist, binds to cytoplasmic receptors, translocates to the nucleus, and subsequently initiates the transcription of glucocorticoid-respon...		Glucocorticoid Receptor , Autophagy
T0782	Benzthiazide	Aquatag,Lemazide,Dihydrex	Carbonic Anhydrase
	Benzthiazide (Lemazide) is used in the therapy of edema and hypertension. Like other thiazides, benzthiazide accelerates water loss from the body (diuretics). They inhibit Na+/Cl- reabsorption from the distal convoluted ...		Carbonic Anhydrase
T26490	AA 193	AA-193,AA193
	AA 193 selectively inhibits the presecretory reabsorption of uric acid.
TP2098	Echistatin	Echistatin, α1 isoform
	Potent irreversible αVβ3 integrin antagonist (Ki = 0.27 nM). Disrupts attachment of osteoclasts to bone and inhibits bone reabsorption (IC50 = 0.1 nM). Prevents ADP-induced platelet aggregation via inhibition of glycopro...
T72143	Velagliflozin proline hydrate
	Velagliflozin proline hydrate, the clinical form of Velagliflozin, is an oral sodium-glucose cotransporter 2 (SGLT2) inhibitor exhibiting antidiabetic activity. By decreasing renal glucose reabsorption and promoting glyc...
T70390	YM-543 choline
	YM-543, also known as ASP-543, is a selective SGLT2 inhibitor. Sodium-glucose cotransporter 2 (SGLT2) is a specifically expressed transporter in the kidney that plays an important role in renal glucose reabsorption, and ...