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Fludrocortisone acetate

Catalog No. T1666   CAS 514-36-3
Synonyms: 醋酸氟氢可的松, 9α-Fludrocortisone acetate, 9α-Fluorcortisol acetate, 9α-fluorocortisol acetate

Fludrocortisone, a glucocorticoid-receptor agonist, binds to cytoplasmic receptors, translocates to the nucleus, and subsequently initiates the transcription of glucocorticoid-responsive genes such as lipocortins to inhibit phospholipase A2 (PLA2). Fludrocortisone Acetate is the acetate salt of a synthetic fluorinated corticosteroid with anti-inflammatory and antiallergic activities. Inhibition of PLA2 activity prevents the release of arachidonic acid, a precursor of eicosanoids such as prostaglandins and leukotrienes; eicosanoids are important mediators in the pro-inflammatory response mechanism. As a mineralocorticoid-receptor agonist, this agent stimulates Na+ reabsorption and water retention and K+ and H+ secretion in the distal tubules and collecting ducts of the kidney.

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Fludrocortisone acetate, CAS 514-36-3
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Purity: 98%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Fludrocortisone, a glucocorticoid-receptor agonist, binds to cytoplasmic receptors, translocates to the nucleus, and subsequently initiates the transcription of glucocorticoid-responsive genes such as lipocortins to inhibit phospholipase A2 (PLA2). Fludrocortisone Acetate is the acetate salt of a synthetic fluorinated corticosteroid with anti-inflammatory and antiallergic activities. Inhibition of PLA2 activity prevents the release of arachidonic acid, a precursor of eicosanoids such as prostaglandins and leukotrienes; eicosanoids are important mediators in the pro-inflammatory response mechanism. As a mineralocorticoid-receptor agonist, this agent stimulates Na+ reabsorption and water retention and K+ and H+ secretion in the distal tubules and collecting ducts of the kidney.
Synonyms 醋酸氟氢可的松, 9α-Fludrocortisone acetate, 9α-Fluorcortisol acetate, 9α-fluorocortisol acetate
Molecular Weight 422.493
Formula C23H31FO6
CAS No. 514-36-3

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 10 mM

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Related compound libraries

This product is contained In the following compound libraries：
Anti-Cancer Compound Library Autophagy Compound Library GPCR Compound Library Glycometabolism Compound Library Anti-Cancer Metabolism Compound Library Endocrinology-Hormone Compound Library Immunology/Inflammation Compound Library Anti-Metabolism Disease Compound Library Fluorochemical Library Drug Repurposing Compound Library

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Hirsutenone Flavoglaucin Lup-20(29)-en-28-oic acid Onjisaponin B PTC-209 hydrobromide PF-543 Brivanib LYN-1604

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Keywords

Fludrocortisone acetate 514-36-3 内分泌与激素 自噬 Autophagy Glucocorticoid Receptor Fludrocortisone Inhibitor 9α-Fludrocortisone 9α-Fluorcortisol acetate 9α-Fluorcortisol 9α-Fludrocortisone acetate inhibit Mineralocorticoid Receptor 9α-fluorocortisol acetate inhibitor

 

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