Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Fludrocortisone acetate (9α-Fludrocortisone acetate) , a glucocorticoid-receptor agonist, binds to cytoplasmic receptors, translocates to the nucleus, and subsequently initiates the transcription of glucocorticoid-responsive genes such as lipocortins to inhibit phospholipase A2 (PLA2). Fludrocortisone acetate is the acetate salt of a synthetic fluorinated corticosteroid with anti-inflammatory and antiallergic activities. Inhibition of PLA2 activity prevents the release of arachidonic acid, a precursor of eicosanoids such as prostaglandins and leukotrienes; eicosanoids are important mediators in the pro-inflammatory response mechanism. As a mineralocorticoid-receptor agonist, this agent stimulates Na+ reabsorption and water retention and K+ and H+ secretion in the distal tubules and collecting ducts of the kidney.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
100 mg | In stock | $ 47.00 | |
200 mg | In stock | $ 68.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 47.00 |
Description | Fludrocortisone acetate (9α-Fludrocortisone acetate) , a glucocorticoid-receptor agonist, binds to cytoplasmic receptors, translocates to the nucleus, and subsequently initiates the transcription of glucocorticoid-responsive genes such as lipocortins to inhibit phospholipase A2 (PLA2). Fludrocortisone acetate is the acetate salt of a synthetic fluorinated corticosteroid with anti-inflammatory and antiallergic activities. Inhibition of PLA2 activity prevents the release of arachidonic acid, a precursor of eicosanoids such as prostaglandins and leukotrienes; eicosanoids are important mediators in the pro-inflammatory response mechanism. As a mineralocorticoid-receptor agonist, this agent stimulates Na+ reabsorption and water retention and K+ and H+ secretion in the distal tubules and collecting ducts of the kidney. |
Synonyms | 9α-Fluorcortisol acetate, 9α-Fludrocortisone acetate, 9α-fluorocortisol acetate |
Molecular Weight | 422.49 |
Formula | C23H31FO6 |
CAS No. | 514-36-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 45 mg/mL (106.51 mM)
You can also refer to dose conversion for different animals. More
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Fludrocortisone acetate 514-36-3 Autophagy Endocrinology/Hormones Glucocorticoid Receptor 9α-Fluorcortisol acetate Fludrocortisone Fludrocortisone Acetate 9alpha-fluorocortisol Acetate 9α-Fludrocortisone acetate Inhibitor 9alpha-Fludrocortisone Acetate 9a-fluorocortisol Acetate 9α-Fludrocortisone Acetate 9α-fluorocortisol acetate 9α-Fluorcortisol Acetate 9α-Fludrocortisone 9a-Fluorcortisol Acetate 9α-Fluorcortisol inhibit Mineralocorticoid Receptor 9a-Fludrocortisone Acetate 9α-fluorocortisol Acetate 9alpha-Fluorcortisol Acetate inhibitor