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Dotinurad

Name: Dotinurad
Brand: TargetMol
SKU: T15160
Price: 132 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15160Cas No. 1285572-51-1

Alias (3,5-dichloro-4-hydroxyphenyl)(1,1-dioxidobenzo[d]thiazol-3(2H)-yl)methanone

Dotinurad ((3,5-dichloro-4-hydroxyphenyl)(1,1-dioxidobenzo[d]thiazol-3(2H)-yl)methanone) is a potent agent of uricosuric (IC50: 3.6 μM for uric acid).

Dotinurad

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Purity: 98.04%

Catalog No. T15160Alias (3,5-dichloro-4-hydroxyphenyl)(1,1-dioxidobenzo[d]thiazol-3(2H)-yl)methanoneCas No. 1285572-51-1

Dotinurad ((3,5-dichloro-4-hydroxyphenyl)(1,1-dioxidobenzo[d]thiazol-3(2H)-yl)methanone) is a potent agent of uricosuric (IC50: 3.6 μM for uric acid).

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$132	In Stock	In Stock
5 mg	$322	In Stock	In Stock
10 mg	$497	In Stock	In Stock
25 mg	$819	In Stock	In Stock
50 mg	$1,090	In Stock	In Stock
100 mg	$1,490	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$252	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98.04%

Color:White

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COA HNMR LCMS

Product Introduction

Dotinurad AI Summary

Dotinurad is a multifaceted bioactive agent with diverse interactions and pharmacokinetics. It inhibits uricase1 with an IC50 of 3600.0 nM and exhibits strong inhibition of human URAT1, particularly in Xenopus laevis oocytes, with an IC50 of 37.2 nM and an inhibition percentage of 78.0% at 0.1 μM. Additionally, it inhibits URAT1 in human RPTEC, achieving an IC50 of 6800.0 nM and 81.0% inhibition at 10 μM concentration. In Cebus monkeys, it shows a uricosuric effect with an activity of 16.5%. The compound is hepatotoxic to rat liver mitochondria, with an IC50 of 27000.0 nM, and inhibits CYP2C9 with an IC50 of 5700.0 nM. Pharmacokinetic studies reveal it achieves a Cmax of 25516.47 nM in rats when administered orally at 3 mg/kg, with a 1.1% excretion rate in rat urine over 4 hours. In drug metabolism studies, Dotinurad shows significant metabolism in rat plasma (81.9%), cynomolgus monkey plasma (92.0%), and human plasma (80.9%). The compound also demonstrates excretion in human urine, with 44.3% as the glucuronide metabolite and 20.0% as the sulfate metabolite of phenols. These attributes underscore the compound's potent inhibitory effects and efficient metabolic profile across different species..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Dotinurad ((3,5-dichloro-4-hydroxyphenyl)(1,1-dioxidobenzo[d]thiazol-3(2H)-yl)methanone) is a potent agent of uricosuric (IC50: 3.6 μM for uric acid).
Targets&IC50	URAT1:37.2nM
Synonyms	(3,5-dichloro-4-hydroxyphenyl)(1,1-dioxidobenzo[d]thiazol-3(2H)-yl)methanone

Chemical Properties

Molecular Weight	358.2
Formula	C₁₄H₉Cl₂NO₄S
Cas No.	1285572-51-1
Smiles	C(=O)(N1C=2C(S(=O)(=O)C1)=CC=CC2)C3=CC(Cl)=C(O)C(Cl)=C3
Relative Density.	1.662 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 240 mg/mL (670.02 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7917 mL	13.9587 mL	27.9174 mL	139.5868 mL
5 mM	0.5583 mL	2.7917 mL	5.5835 mL	27.9174 mL
10 mM	0.2792 mL	1.3959 mL	2.7917 mL	13.9587 mL
20 mM	0.1396 mL	0.6979 mL	1.3959 mL	6.9793 mL
50 mM	0.0558 mL	0.2792 mL	0.5583 mL	2.7917 mL
100 mM	0.0279 mL	0.1396 mL	0.2792 mL	1.3959 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc