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Mildronate

Catalog No. T3268 CAS 76144-81-5

Synonyms: Kvaterin, Meldonium, Quaterin

Mildronate (Meldonium) is an inhibitor of biosynthesis of L-carnitine by gamma-butyrobetaine (GBB) hydroxylase and as a competitive inhibitor of renal carnitine reabsorption.

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Mildronate, CAS 76144-81-5

Pack Size	Availability	Price/USD	Quantity
100 mg	In stock	$ 42.00
200 mg	In stock	$ 58.00

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Mildronate (Meldonium) is an inhibitor of biosynthesis of L-carnitine by gamma-butyrobetaine (GBB) hydroxylase and as a competitive inhibitor of renal carnitine reabsorption.
Targets&IC50	OCTN2 (human):21 μM (EC50), BBOX (human recombinant):34-62 μM (IC50)
In vitro	Mildronate (40 μM) inhibits the reaction of γ-butyrobetaine hydroxylase with γ-butyrobetaine with Km and Vmax of 36.8 μM and 0.08 nmol/min/mg protein, respectively. [1]

Synonyms	Kvaterin, Meldonium, Quaterin
Molecular Weight	146.19
Formula	C6H14N2O2
CAS No.	76144-81-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 10 mM

DMSO: Insoluble

References and Literature

1. Simkhovich BZ, et al. Biochem Pharmacol, 1988, 37(2), 195-202. 2. Liepinsh E, et al. Life Sci, 2008, 83(17-18), 613-619. 3. Pupure J, et al. Neurosci Lett, 2010, 470(2), 100-105. 4. Liepinsh E, et al. Br J Pharmacol, 2009, 157(8), 1549-1556. 6. Schobersberger W, et al. Story behind meldonium-from pharmacology to performance enhancement: a narrative review. Br J Sports Med. 2017 Jan;51(1):22-25.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Inhibitor Library Bioactive Compounds Library Max ReFRAME Related Library Metabolism Compound Library NO PAINS Compound Library Anti-Cardiovascular Disease Compound Library Approved Drug Library Anti-Metabolism Disease Compound Library Human Metabolite Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Mildronate 76144-81-5 Metabolism Hydroxylase Kvaterin supplier glycolysis β-oxidation ischaemic Meldonium MET88 Quaterin mitochondria inhibit MET 88 Inhibitor MET-88 peroxisomes inhibitor

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