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Benzthiazide

Catalog No. T0782   CAS 91-33-8
Synonyms: Aquatag, Lemazide, Dihydrex

Benzthiazide (Lemazide) is used in the therapy of edema and hypertension. Like other thiazides, benzthiazide accelerates water loss from the body (diuretics). They inhibit Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium and an increase in serum uric acid. Thiazides are often used to treat hypertension, but their hypotensive effects are not necessarily due to their diuretic activity. Thiazides have been shown to prevent hypertension-related morbidity and mortality although the mechanism is not fully understood. Thiazides cause vasodilation by activating calcium-activated potassium channels (large conductance) in vascular smooth muscles and inhibiting various carbonic anhydrases in vascular tissue.

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Benzthiazide Chemical Structure
Benzthiazide, CAS 91-33-8
Pack Size Availability Price/USD Quantity
100 mg In stock $ 39.00
1 mL * 10 mM (in DMSO) In stock $ 43.00
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Purity: 99.79%
Purity: 99.34%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Benzthiazide (Lemazide) is used in the therapy of edema and hypertension. Like other thiazides, benzthiazide accelerates water loss from the body (diuretics). They inhibit Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium and an increase in serum uric acid. Thiazides are often used to treat hypertension, but their hypotensive effects are not necessarily due to their diuretic activity. Thiazides have been shown to prevent hypertension-related morbidity and mortality although the mechanism is not fully understood. Thiazides cause vasodilation by activating calcium-activated potassium channels (large conductance) in vascular smooth muscles and inhibiting various carbonic anhydrases in vascular tissue.
Targets&IC50 CA1:10 nM (Ki), CA9:8.0 nM (Ki), CA2:8.8 nM (Ki)
Synonyms Aquatag, Lemazide, Dihydrex
Molecular Weight 431.94
Formula C15H14ClN3O4S3
CAS No. 91-33-8

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 45 mg/mL (104.19 mM)

TargetMolReferences and Literature

1. Temperini C, et al. Bioorg Med Chem. 2009 Feb 1;17(3):1214-21.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Approved Drug Library Anti-Cancer Drug Library Anti-Cancer Active Compound Library Bioactive Compounds Library Max Immunology/Inflammation Compound Library Bioactive Compound Library Ion Channel Inhibitor Library Metabolism Compound Library Anti-Hypertension Compound Library FDA-Approved Drug Library

Related Products

Related compounds with same targets
hCAI/II/IV-IN-28 Ethoxzolamide Ellagic acid Halazone Acetazolamide sodium CAIX Inhibitor S4 EMAC10101d hCAIX/XII-IN-8

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Keywords

Benzthiazide 91-33-8 Metabolism Carbonic Anhydrase Inhibitor Carbonate dehydratase Aquatag Lemazide Dihydrex inhibit inhibitor

 

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