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Desmopressin

Catalog No. T5019   CAS 16679-58-6
Synonyms: DDAVP, Desmopressin Acetate

Desmopressin (DDAVP)(DDAVP) is the synthetic analogue of the antidiuretic hormone arginine vasopressin.Vasopressin Receptor The antidiuretic properties of desmopressin have led to its use in polyuric conditions including primary nocturnal enuresis, nocturia, and diabetes insipidus. Desmopressin works by limiting the amount of water that is eliminated in the urine. Desmopressin binds to V2 receptors in renal collecting ducts, increasing water reabsorption. It also stimulates release of von Willebrand factor from endothelial cells by acting on the V2 receptor.

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Desmopressin Chemical Structure
Desmopressin, CAS 16679-58-6
Pack Size Availability Price/USD Quantity
1 mg In stock $ 43.00
5 mg In stock $ 95.00
10 mg In stock $ 152.00
25 mg In stock $ 315.00
50 mg In stock $ 453.00
100 mg In stock $ 668.00
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Purity: 97.45%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Desmopressin (DDAVP)(DDAVP) is the synthetic analogue of the antidiuretic hormone arginine vasopressin.Vasopressin Receptor The antidiuretic properties of desmopressin have led to its use in polyuric conditions including primary nocturnal enuresis, nocturia, and diabetes insipidus. Desmopressin works by limiting the amount of water that is eliminated in the urine. Desmopressin binds to V2 receptors in renal collecting ducts, increasing water reabsorption. It also stimulates release of von Willebrand factor from endothelial cells by acting on the V2 receptor.
Synonyms DDAVP, Desmopressin Acetate
Molecular Weight 1069.22
Formula C46H64N14O12S2
CAS No. 16679-58-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 10mM

TargetMolReferences and Literature

1. Walle J V , Stockner M , Raes A , et al. Desmopressin 30 Years in Clinical Use: A Safety Review[J]. Current Drug Safety, 2007, 2(3):-. 2. Sánchez-Luceros A, Meschengieser SS, Woods AI et al. Biological and clinical response to desmopressin (DDAVP) in a retrospective cohort study of children with low von Willebrand factor levels and bleeding history. Thromb Haemost. 2010 Nov;104(5):984-9. 3. Alonso DF, Ripoll GV, Garona J et al. Metastasis: recent discoveries and novel perioperative treatment strategies with particular interest in the hemostatic compound desmopressin. Curr Pharm Biotechnol. 2011 Nov;12(11):1974-80. 4. Tsukamoto I. Recent patenting activities in the discovery and development of vasopressin V2 receptor agonists. Expert Opin Ther Pat. 2012 Jun;22(6):579-86. 5. Franchini M, Zaffanello M, Lippi G. The use of desmopressin in mild hemophilia A. Blood Coagul Fibrinolysis. 2010 Oct;21(7):615-9.

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Keywords

Desmopressin 16679-58-6 GPCR/G Protein Vasopressin Receptor DDAVP Desmopressin Acetate inhibitor inhibit

 

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