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Search Result

Search Results for " p70 "

Targets

Others HSP

21

Compounds

22

Recombinant Proteins

1

Libraries

Cat No. Product Name Synonyms Targets
T3487 HSP70-IN-1 Others , HSP
HSP70-IN-1 is a heat shock protein (HSP) inhibitor and inhibits the growth of Kasumi-1 cells (IC50: 2.3 μM).
TP1616L Hsp70-derived octapeptide acetate Hsp70-derived octapeptide acetate(736171-62-3 free base) Others
Hsp70-derived octapeptide acetate (Hsp70-derived octapeptide acetate) is a group of tetratricopeptide repeat (TPR)-containing proteins has been shown to interact with the C-terminal domain of the 70 kDa heat-shock cognat...
T71199 CGP7040
CGP7040 is a rifamycin analogue, is a protein 50S ribosomal subunit inhibitor that was being developed by Novartis.
T74278 HSP70-IN-3
HSP70-IN-3, a potent inhibitor of HSP70 with IC50 values of 1.1 μM in ASZ001 cells and 1.9 μM in C3H10T1/2 cells, exhibits anti-Hedgehog (Hh) signaling and anti-proliferative activities. Furthermore, it reduces the expre...
TP1616 Hsp70-derived octapeptide
A group of tetratricopeptide repeat (TPR)-containing proteins has been shown to interact with the C-terminal domain of the 70 kDa heat-shock cognate protein (hsc70). In the present study, the effect of the TPR-containing...
T82168 HSP70/SIRT2-IN-1 Sirtuin
HSP70/SIRT2-IN-1 (Compound 2a) serves as a dual inhibitor targeting both SIRT2 and HSP70, exhibiting an IC50 of 17.3±2.0 μM against SIRT2. This compound possesses antitumor activity [1].
T82167 HSP70/SIRT2-IN-2 HSP
HSP70/SIRT2-IN-2 (Compounds 1a), a dual inhibitor of SIRT2 and HSP70, exhibits an IC50 of 45.1±5.0 μM against SIRT2 and demonstrates antitumor activity [1].
T2002 PF-4708671 PF4708671 S6 Kinase , Autophagy
PF-4708671 is a cell-permeable inhibitor of p70 ribosomal S6 kinase (S6K1 isoform) .In cell-free assays, PF-4708671(PF4708671) is potent for S6K1(Ki50=20 nM, IC50=160 nM).
T1746 LY-2584702 tosylate salt LY2584702 tosylate S6 Kinase
LY-2584702 tosylate salt is a selective, ATP-competitive p70S6K inhibitor, used in trials studying the treatment of cancer.
T6159 LY-2584702 free base S6 Kinase , mTOR
LY2584702 is a selective, ATP-competitive p70S6K inhibitor(IC50: 4 nM).
T6303L CCT128930 hydrochloride CCT128930 hydrochloride(885499-61-6 Free base) Apoptosis , Akt , PKA , mTOR , Autophagy
CCT128930 hydrochloride (CCT128930 hydrochloride) is a potent and selective inhibitor of AKT with IC50 of 6 nM. CCT128930 hydrochloride induces cell cycle arrest, DNA damage, and autophagy. CCT128930 hydrochloride has 28...
T11928 M2698 MSC2363318A Akt , mTOR
M2698 (MSC2363318A) is an inhibitor of p70S6K, Akt1 and Akt3 with IC50s of 1 nM. M2698 shows anti-cancer activity.
TP1978 11R-VIVIT NFAT inhibitor, Cell Permeable
NFAT inhibitor. Inhibits LPS or LPS plus IFN-γ-induced IL-12 p40, IL-12 p70, IL-23 and TNF secretion from bone marrow-derived macrophages (BMDMs). Also attenuates NO production and Nos2 mRNA expression in LPS-stimulated ...
T2482 AT13148 ROCK , SGK , Akt , PKA , S6 Kinase
AT13148 is an oral-active and ATP-competitive, multi-AGC kinase inhibitor for Akt1/2/3, p70S6K, PKA, and ROCKI/II.
T6304 AT7867 Akt , PKA , S6 Kinase
AT7867 is a potent ATP-competitive inhibitor of Akt1/2/3 and p70S6K/PKA with IC50 of 32 nM/17 nM/47 nM and 85 nM/20 nM, respectively; little activity outside the AGC kinase family.
T1920 Capivasertib AZD5363 Akt , PKA , mTOR , Autophagy
Capivasertib (AZD5363) is a broad-spectrum AKT inhibitor with inhibitory activity against Akt1, Akt2, and Akt3 (IC50=3/7/7 nM) with oral activity. Capivasertib has antitumor activity for the treatment of breast cancer.
T39733 Hu7691 free base Akt
Hu7691 free base is an orally active, potent and selective Akt inhibitor with anti-proliferative and neurogenic effects on a variety of neuroblastoma cell lines.Hu7691 free base inhibits Akt1, Akt2, and Akt3 and induces ...
T11900 LY-2584702 hydrochloride S6 Kinase
Ly-2584702 hydrochloride is a p70S6K selective ATP competitive inhibitor with IC50 of 4 nM.In the S6K1 enzyme assay, the IC50 of LY-2584702 was 2 nM.
T10275 AKT-IN-3 Akt
AKT-IN-3 is a potent, orally active low hERG blocking Akt inhibitor (IC50: 1.4 nM, 1.2 nM, and 1.7 nM for Akt1, Akt2, and Akt3). AKT-IN-3 (compound E22) also exhibits good inhibitory activity against other AGC family kin...
T10274 AKT-IN-2 Akt
AKT-IN-2 is a selective, and orally bioavailable AKT inhibitor (IC50: 5 nM for AKT1).
T39899 Hu7691 Akt
Hu7691 is an orally active, selective and potent Akt inhibitor that inhibits Akt1, Akt2 and Akt3, inhibits proliferation of neuroblastoma cells and induces differentiation of neuroblastoma cells.

Recombinant Proteins

Species：
Human (13)
Mouse (3)
Chicken (2)
Apis mellifera (1)
Cynomolgus (1)
Rat (1)
Toxoplasma gondii (1)
Expression System：
HEK293 Cells (13)
Baculovirus Insect Cells (4)
E. coli (4)
P. pastoris (Yeast) (1)
Tag：
C-His (5)
N-His (4)
N-6xHis (3)
C-hFc (2)
Tag Free (2)
C-His-Avi (1)
C-mFc (1)
His, Avi (1)
N-10xHis (1)
N-10xHis, C-Myc (1)
Cat No. Product Name Species Expression System
TMPY-00860 CD122/IL2RB Protein, Human, Recombinant Human HEK293 Cells
CD122/IL2RB Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 25.2 kDa and the accession number is P14784.
TMPY-05680 CD122/IL2RB Protein, Human, Recombinant (mFc) Human HEK293 Cells
CD122/IL2RB Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 51 kDa and the accession number is P14784.
TMPY-05216 CD122/IL2RB Protein, Human, Recombinant (His) Human Baculovirus Insect Cells
CD122/IL2RB Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 26 kDa and the accession number is P14784.
TMPY-05784 CD122/IL2RB Protein, Mouse, Recombinant (hFc) Mouse HEK293 Cells
CD122/IL2RB Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 51.76 kDa and the accession number is P16297.
TMPY-04031 CD122/IL2RB Protein, Mouse, Recombinant (His) Mouse HEK293 Cells
CD122/IL2RB Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.5 kDa and the accession number is P16297.
TMPY-04540 S6K1/RPS6KB1 Protein, Human, Recombinant (GST) Human Baculovirus Insect Cells
PS6K, also known as RPS6KB1, is a serine/threonine-protein kinase. It belongs to the RSK (ribosomal s6 kinase) family. Members of this family function in signal transduction. PS6K is an isoform of p70 ribosomal S6 kinase...
TMPY-04863 IL-12 Protein, Human, Recombinant Human HEK293 Cells
IL-12 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 57.2 kDa and the accession number is P29459-1&NP_002178.2.
TMPY-00859 CD122/IL2RB Protein, Human, Recombinant (hFc) Human HEK293 Cells
CD122/IL2RB Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 51.3 kDa and the accession number is P14784.
TMPY-06515 CD122/IL2RB Protein, Human, Recombinant (His & Avi), Biotinylated Human HEK293 Cells
CD122/IL2RB Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 28.73 kDa and the accession number is NP_000869.1.
TMPY-03440 Sts1 Protein, Human, Recombinant (His) Human E. coli
UBASH3B contains a ubiquitin associated domain at the N-terminus, an SH3 domain, and a C-terminal domain with similarities to the catalytic motif of phosphoglycerate mutase. UBASH3B was found to inhibit endocytosis of ep...
TMPY-02109 IL-12 Protein, Human, Recombinant (His) Human HEK293 Cells
IL-12 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 60.13 kDa and the accession number is P29459-1&NP_002178.2.
TMPY-05458 IL-12 Protein, Human, Recombinant (His), Biotinylated Human HEK293 Cells
IL-12 Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 60.13 kDa and the accession number is P29459.2&NP_002178.2.
TMPK-00320 IL-2 R beta/CD122 Protein, Human, Recombinant (His & Avi) Human HEK293 Cells
IL-2 R beta/CD122 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 27.5 kDa and the accession number is P14784.
TMPK-00321 IL-2 R beta/CD122 Protein (Primary Amine Labeling), Cynomolgus, Recombinant (His), Biotinylated Cynomolgus HEK293 Cells
IL-2 R beta/CD122 Protein (Primary Amine Labeling), Cynomolgus, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 25.6 kDa and the accession number i...
TMPY-02443 HSP70 Protein, Human, Recombinant (His) Human Baculovirus Insect Cells
HSP70 Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 72.2 kDa and the accession number is A8K5I0.
TMPY-06092 HSP70 Protein, Rat, Recombinant (His) Rat HEK293 Cells
HSP70 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 71.6 kDa and the accession number is A6KTP2.
TMPY-06091 HSP70 Protein, Mouse, Recombinant (His) Mouse HEK293 Cells
HSP70 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 71.5 kDa and the accession number is Q3TU85.
TMPH-02280 SNRNP70 Protein, Human, Recombinant (His) Human E. coli
Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRNP70 binds to the loop I region of U1-snRNA.; Truncated isoform...
TMPH-03636 HSP70 Protein, Toxoplasma gondii, Recombinant (His) Toxoplasma gondii E. coli
N/A. HSP70 Protein, Toxoplasma gondii, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 78.9 kDa and the accession number is A0A125YXI9.
TMPH-00371 HSP70 Protein, Chicken, Recombinant (His) Chicken E. coli
HSP70 Protein, Chicken, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 48.6 kDa and the accession number is P08106.
TMPH-00765 HSP70 Protein, Gallus gallus, Recombinant (His & Myc) Chicken Baculovirus Insect Cells
HSP70 Protein, Gallus gallus, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag. The predicted molecular weight is 46.5 kDa and the accession number is P08106.
TMPH-00064 MRJP1 Protein, Apis mellifera, Recombinant (His) Apis mellifera P. pastoris (Yeast)
Induces the differentiation of honeybee larvae into queens through an Egfr-mediated signaling pathway. Promotes body size increase by activating p70 S6 kinase, stimulates ovary development by augmenting the titer of vite...
CD122/IL2RB Protein, Human, Recombinant
TMPY-00860
Species: Human
Expression System: HEK293 Cells
CD122/IL2RB Protein, Human, Recombinant (mFc)
TMPY-05680
Species: Human
Expression System: HEK293 Cells
CD122/IL2RB Protein, Human, Recombinant (His)
TMPY-05216
Species: Human
Expression System: Baculovirus Insect Cells
CD122/IL2RB Protein, Mouse, Recombinant (hFc)
TMPY-05784
Species: Mouse
Expression System: HEK293 Cells
CD122/IL2RB Protein, Mouse, Recombinant (His)
TMPY-04031
Species: Mouse
Expression System: HEK293 Cells
S6K1/RPS6KB1 Protein, Human, Recombinant (GST)
TMPY-04540
Species: Human
Expression System: Baculovirus Insect Cells
IL-12 Protein, Human, Recombinant
TMPY-04863
Species: Human
Expression System: HEK293 Cells
CD122/IL2RB Protein, Human, Recombinant (hFc)
TMPY-00859
Species: Human
Expression System: HEK293 Cells
CD122/IL2RB Protein, Human, Recombinant (His & Avi), Biotinylated
TMPY-06515
Species: Human
Expression System: HEK293 Cells
Sts1 Protein, Human, Recombinant (His)
TMPY-03440
Species: Human
Expression System: E. coli
IL-12 Protein, Human, Recombinant (His)
TMPY-02109
Species: Human
Expression System: HEK293 Cells
IL-12 Protein, Human, Recombinant (His), Biotinylated
TMPY-05458
Species: Human
Expression System: HEK293 Cells
IL-2 R beta/CD122 Protein, Human, Recombinant (His & Avi)
TMPK-00320
Species: Human
Expression System: HEK293 Cells
IL-2 R beta/CD122 Protein (Primary Amine Labeling), Cynomolgus, Recombinant (His), Biotinylated
TMPK-00321
Species: Cynomolgus
Expression System: HEK293 Cells
HSP70 Protein, Human, Recombinant (His)
TMPY-02443
Species: Human
Expression System: Baculovirus Insect Cells
HSP70 Protein, Rat, Recombinant (His)
TMPY-06092
Species: Rat
Expression System: HEK293 Cells
HSP70 Protein, Mouse, Recombinant (His)
TMPY-06091
Species: Mouse
Expression System: HEK293 Cells
SNRNP70 Protein, Human, Recombinant (His)
TMPH-02280
Species: Human
Expression System: E. coli
HSP70 Protein, Toxoplasma gondii, Recombinant (His)
TMPH-03636
Species: Toxoplasma gondii
Expression System: E. coli
HSP70 Protein, Chicken, Recombinant (His)
TMPH-00371
Species: Chicken
Expression System: E. coli
HSP70 Protein, Gallus gallus, Recombinant (His & Myc)
TMPH-00765
Species: Chicken
Expression System: Baculovirus Insect Cells
MRJP1 Protein, Apis mellifera, Recombinant (His)
TMPH-00064
Species: Apis mellifera
Expression System: P. pastoris (Yeast)
Cat No. Product Name
L1300 PI3K-AKT-mTOR Compound Library

420 compounds
A unique collection of 420 compounds targeting PI3K/Akt/mTOR signaling for research in PI3K/Akt/mTOR signaling, and drug discovery in diseases involved with PI3K/Akt/mTOR signaling;

Libraries

PI3K-AKT-mTOR Compound Library
L1300
Compounds: 420
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