Powder: -20°C for 3 years | In solvent: -80°C for 1 year
HSP70-IN-1 is a heat shock protein (HSP) inhibitor and inhibits the growth of Kasumi-1 cells (IC50: 2.3 μM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 98.00 | |
5 mg | In stock | $ 327.00 | |
10 mg | In stock | $ 497.00 | |
25 mg | In stock | $ 793.00 | |
50 mg | In stock | $ 1,130.00 | |
100 mg | In stock | $ 1,520.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 333.00 |
Description | HSP70-IN-1 is a heat shock protein (HSP) inhibitor and inhibits the growth of Kasumi-1 cells (IC50: 2.3 μM). |
Targets&IC50 | HSP:2.3 μM |
In vitro | Heat shock protein 70 (Hsp70) functions as a molecular chaperone crucial for protein homeostasis, cell signaling, and survival, with its overexpression observed in cancer contributing to chemotherapy resistance. HSP70-IN-1 disrupts this by dose-dependently affecting the formation and stability of the Hsp70-HOP-Hsp90 complex, crucial for cancer cell survival, including altering components of this megacomplex and destabilizing the Hsp70-Hsp90 machinery client, Raf-1. It also inhibits the refolding capability of endogenous and transfected Hsp70 for heat-denatured luciferase in cells, and induces apoptosis in cancer cells by modifying the Hsp70-HOP complex formation and stability, leading to their reduced half-life. |
Molecular Weight | 464.58 |
Formula | C24H28N6O2S |
CAS No. | 1268273-90-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 45 mg/mL (96.86 mM)
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
HSP70-IN-1 1268273-90-0 Cytoskeletal Signaling Metabolism Others HSP HSP70 IN 1 inhibit HSP-70-IN-1 Heat shock proteins Inhibitor HSP70IN1 inhibitor