osteosarcoma — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T70841	Osteosarcoma-IN-D14
	Osteosarcoma-IN-D14 is an inhibitor of migration and invasion of osteosarcoma cells mediated by p53, regulating EMT-related genes.
T21876	DC_AC50		Apoptosis , Others
	DC_AC50 is a dual inhibitor of Atox1 and CCS (copper chaperones). Inhibiting intracellular copper chaperones as a means of reducing/preventing acquired chemotherapy resistance.DC_AC50 binding to Atox1 and CCS and reducin...		Apoptosis , Others
T70839	S 14063
	S 14063 is a potent 5-HT1A receptor antagonist devoid of beta-adrenoceptor blocking properties.
T9102	WM-3835		Apoptosis , Histone Methyltransferase , Histone Acetyltransferase
	WM-3835 is a novel and high-specific small molecule inhibitor of Lysine Acetyltransferase 7 (KAT7, MYST2, HBO1) , able to potently suppressed OS cell proliferation and migration, and leads to apoptosis activation.
T3878	Raddeanin A	NSC382873,Anemodeanin A,Raddeanin R3	Apoptosis , HDAC
	Raddeanin A (NSC-382873) has moderate inhibitory activity against histone deacetylases (HDACs). Raddeanin A has high antiangiogenic potency, antitumor activity.		Apoptosis , HDAC
T14364	AZ-Dyrk1B-33	3-(2-Methyl-4-pyrimidinyl)-1-(phenylmethyl)-1H-pyrrolo[2,3-c]pyridine	DYRK
	AZ-Dyrk1B-33 (3-(2-Methyl-4-pyrimidinyl)-1-(phenylmethyl)-1H-pyrrolo[2,3-c]pyridine) is a potent and selective Dyrk1B kinase inhibitor with an IC50 of 7 nM.		DYRK
T5S0803	Columbamine	Columbamin,Dehydroisocorypalmine	Others
	Columbamine (Columbamin) shows strong activity with IC5 48.1 μM.Columbamine exerts anti-proliferative and anti-vasculogenic effects on metastatic human osteosarcoma U2OS cells with low toxicity.		Others
T0484	Deracoxib	SC 46,SC 046,SC 59046	Apoptosis , COX
	Deracoxib (SC 46) is a non-steroidal, non-narcotic anti-inflammatory drug. It is also a selective cyclooxygenase-2 inhibitor, and IC50 Value: 70 to 150 μM(inhibition of 3 osteosarcoma cell lines).		Apoptosis , COX
T13174	TMPyP4 tosylate	TMP 1363	DNA/RNA Synthesis , Telomerase
	TMPyP4 tosylate (TMP 1363) is a quadruplex-specific ligand and is a telomerase inhibitor with antitumor effects in osteosarcoma cell lines.		DNA/RNA Synthesis , Telomerase
T5S0053	Coptisine	Coptisin	Indoleamine 2,3-Dioxygenase (IDO)
	1. Coptisine (Coptisin) treatment increases cell viability based on its reversal effect on the enhanced activity of Indoleamine 2, 3-dioxygenase . 2. Coptisine treats myocardial I/R likely through suppressing myocardial ...		Indoleamine 2,3-Dioxygenase (IDO)
T77448	Naxitamab	Naxitamab-gqgk,Humanized 3F8,Hu3F8	Others
	Naxitamab (Hu3F8) is a humanized monoclonal antibody against GD2 (hu3F8). Naxitamab has antitumor activity and can be used to study neuroblastoma, osteosarcoma, and other GD2-positive cancers.		Others
T26869	BMS-986122	BMS 986122	Opioid Receptor
	BMS-986122 (BMS 986122) is a positive allosteric modulator of μ-opioid receptors that increases β-arrestin recruitment stimulated by endomorphin 1 in U2OS-OPRM1 human osteosarcoma cells expressing μ-opioid receptors (EC5...		Opioid Receptor
T60039	KSQ-4279	USP1-IN-1	PARP , DUB
	KSQ-4279 (USP1-IN-1) is an inhibitor of USP1 and PARP.KSQ-4279 has anticancer activity and is used in the study of non-small cell lung cancer, osteosarcoma, ovarian, breast, glioblastoma, bladder, uterine and pancreatic ...		PARP , DUB
T2S1837	Steviol	NSC 226902,Hydroxydehydrostevic acid	Others
	1. Steviol (NSC-226902), a natural sweetener, it inhibits proliferation of the gastrointestinal cancer cells intensively. 2. Steviol can induce a significant increase in CYP3A29 expression. 3. Steviol inhibits the prolif...		Others
T4S1335	Daphnoretin	Dephnoretin,Thymelol	Influenza Virus , Caspase , PKC
	1. Daphnoretin (Thymelol) has strong antiviral activity, mainly on the later phase of the replication cycle. 2. Daphnoretin has anticancer effects on leukemia, osteosarcoma and uterine cervix cancer cells, might through ...		Influenza Virus , Caspase , PKC
T3923	Calycosin	Cyclosin,3'-Hydroxyformononetin	Apoptosis , Tyrosinase
	Calycosin (Cyclosin) acts as a selective estrogen receptor modulator. Calycosin induces apoptosis in human ovarian cancer SKOV3 cells by activating caspases and Bcl-2 family proteins. Calycosin suppresses breast cancer c...		Apoptosis , Tyrosinase
T6S1141	Ganoderic acid A		Apoptosis , NF-κB , Endogenous Metabolite , Autophagy
	1. Ganoderic acid A exhibits antitumor activity, mediated through its inhibitory effect on nuclear transcription factor-kappaB and activator protein-1. 2. Ganoderic acid A can induce proliferation inhibition, apoptosis a...		Apoptosis , NF-κB , Endogenous Metabolite , Autophagy
T12037	Mifamurtide	L-MTP-PE,MTP-PE,CGP 19835	Others
	Mifamurtide is a drug against osteosarcoma, is an immunomodulator with antitumor effects.		Others
T19559	Seocalcitol	EB 1089	Others
	Seocalcitol is an analog of vitamin D, binds vitamin D receptor protein from human osteosarcoma MG-63 cells(Kd : 0.27 nM).		Others
TP2332L	Mifamurtide sodium	Muramyl tripeptide,CGP 19835A,L-MTP-PE,Mepact,Junovan
	Mifamurtide sodium is a drug against osteosarcoma, a kind of bone cancer mainly affecting children and young adults. It was approved in Europe in March 2009.