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Seocalcitol

Catalog No. T19559 CAS 134404-52-7

Synonyms: EB 1089

Seocalcitol is an analog of vitamin D, binds vitamin D receptor protein from human osteosarcoma MG-63 cells(Kd : 0.27 nM).

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Seocalcitol, CAS 134404-52-7

Pack Size	Availability	Price/USD
500 μg	35 days	$ 243.00
1 mg	35 days	$ 460.00
5 mg	35 days	$ 1,930.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	Seocalcitol is an analog of vitamin D, binds vitamin D receptor protein from human osteosarcoma MG-63 cells(Kd : 0.27 nM).
Targets&IC50	Vitamin D receptor:(kd)0.27 nM
In vitro	Seocalcitol is a stimulators of osteoclast recruitment in murine bone marrow cultures(EC50 at 0.1 nM). Seocalcitol stimulates bone resorption(EC50 of 0.03 nM)[1]. Seocalcitol elicites a dose-dependent induction of 24-hydroxylase mRNA in the kidney (EC50=0.4±0.13). In the kidney, Kd values for Seocalcitol is 0.48±0.04 nM. However, in the intestine, the Kd for Seocalcitol is 1.43±0.19 nM)[2]. Seocalcitol (0.1-10 nM) induces cell differentiation in a dosedependent manner. A higher differentiating activity is observed for 1 nM Seocalcitol than for 1 nM VD3.
In vivo	Seocalcitol, a synthetic vitamin D analog, demonstrates lower hypercalcemic activity compared to 1,25(OH)2VD3. Its long-term intraperitoneal (IP) administration at 0.5 μg/kg body weight bi-daily significantly inhibits hepatocellular carcinoma (HCC) development in C3H/Sy mice[4]. Furthermore, when administered intraperitoneally to postnatal rats from days 4 to 12 at dosages of 0.38 or 1.25 μg/kg body weight per day, only the higher dosage (1.25 μg/kg) significantly attenuates weight gain, either as a standalone treatment or when combined with Dexamethasone, all-trans retinoic acid (RA), or retinoic acid[5].

Synonyms	EB 1089
Molecular Weight	454.68
Formula	C30H46O3
CAS No.	134404-52-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (109.97 mM)

References and Literature

1. Wiberg K, et al. Studies on two new vitamin D analogs, EB 1089 and KH 1060: effects on bone resorption and osteoclast recruitment in vitro. Bone. 1995 Oct;17(4):391-5. 2. Roy S, et al. Comparative effects of 1,25-dihydroxyvitamin D3 and EB 1089 on mouse renal and intestinal 25-hydroxyvitamin D3-24-hydroxylase. J Bone Miner Res. 1995 Dec;10(12):1951-9. 3. Bondza-Kibangou P, et al. Antioxidants and doxorubicin supplementation to modulate CD14 expression and oxidative stress induced by vitamin D3 and seocalcitol in HL60 cells. Oncol Rep. 2007 Dec;18(6):1513-9. 4. Ghous Z, et al. Inhibition of hepatocellular cancer by EB1089: in vitro and in vivo study. Anticancer Res. 2008 Nov-Dec;28(6A):3757-61. 5. Ormerod AK, et al. The calcitriol analogue EB1089 impairs alveolarization and induces localized regions of increased fibroblast density in neonatal rat lung. Exp Lung Res. 2008 May;34(4):155-82.

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Keywords

Seocalcitol 134404-52-7 Others EB 1089 EB1089 EB-1089 inhibitor inhibit

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