20
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T2553 | Etofenamate | COX | |
Etofenamate is a non-steroidal anti-inflammatory drug (NSAID) used for the treatment of joint and muscular pain. | |||
T16124 | MMP13-IN-3 | MMP | |
MMP13-IN-3 is >1000 selective over other MMPs. MMP13-IN-3 is an effective, selective, and orally active MMP-13 inhibitor (IC50=1 nM) for the potential treatment of osteoarthritis. | |||
T5689 | 20-DEOXYINGENOL | Others , Autophagy | |
20-DEOXYINGENOL is a natual product. | |||
T1748 | Kartogenin | KGN | TGF-beta/Smad |
Kartogenin (KGN) is an activator of the smad4/smad5 pathway, and promotes the selective differentiation of multipotent mesenchymal stem cells into chondrocytes. | |||
T0291 | Flurbiprofen | dl-Flurbiprofen | Apoptosis , COX , MRP |
Flurbiprofen (dl-Flurbiprofen) is an anti-inflammatory analgesic and antipyretic of the phenylalkynoic acid series. It has been shown to reduce bone resorption in periodontal disease by inhibiting CARBONIC ANHYDRASE. | |||
T9977 | SGK1-IN-4 | SGK | |
SGK1-IN-4 is a selective inhibitor of SGK1 and can be used in studies about osteoarthritis. | |||
T1421 | Aceclofenac | Preservex,Airtal | COX |
Aceclofenac (Preservex) is a non-steroidal anti-inflammatory drug (NSAID) with marked anti-inflammatory and analgesic properties. | |||
T9711 | OGT-IN-2 | Others | |
OGT-IN-2 is a potent O-GlcNAc transferase (OGT) inhibitor. OGT-IN-2 inhibits sOGT and ncOGT with IC50 values of 30 μM and 53 μM, respectively[1]. OGT-IN-2 can be used for the research of articular diseases[1]. | |||
T4561 | Tiaprofenic acid | Tiaprofensaeure,Acido tiaprofenico,Surgam | Others , COX |
Tiaprofenic acid (Acido tiaprofenico) is a non-steroidal anti-inflammatory drug used to treat pain, especially arthritic pain. | |||
T0859 | Fenbufen | CL-82204,Lederfen | ATPase , Caspase , COX |
Fenbufen (Lederfen) is a non-steroidal anti-inflammatory drug used primarily to treat inflammation in osteoarthritis, ankylosing spondylitis, and tendinitis. It can also be used to relieve backaches, sprains, and fractur... | |||
T3803 | Specnuezhenide | Nuzhenide,Nuezhenide | Others , NF-κB , Wnt/beta-catenin |
Specnuezhenide (Nuezhenide) significantly protects human neuroblastoma SH-SY5Y cells from 6-hydroxydopamine-induced neurotoxicity.Nuezhenide is the main inhibitory compound of fruits, it shows a clear inhibitory effect t... | |||
T4552 | Fursultiamine | Diteftin,Judolor,Alinamin F | Others |
Fursultiamine (Alinamin F) is a disulfide derivative of thiamine, or an allithiamine. It has potential uses in the treatment of vitamin B1 deficiency. | |||
T6574 | Lumiracoxib | Prexige,COX-189 | COX |
Lumiracoxib (Prexige) is a novel, selective COX-2 inhibitor with IC50 and Ki of 0.14 μM and 0.06 μM, exhibits 515-fold selectivity over COX-1. Phase 4. | |||
T5029 | Oxaceprol | N-Acetyl-L-hydroxyproline | Others |
Oxaceprol (N-Acetyl-L-hydroxyproline) is an established therapeutic agent for osteoarthritis. | |||
T1780 | Parecoxib | SC 69124,Vorth-P,Valus-P | COX |
Parecoxib (SC 69124) is an effective and selective COX-2 inhibitor. | |||
T6S0117 | Avicularin | Fenicularin | ERK |
Avicularin (Fenicularin) has anti-allergic, anti-inflammatory, hepatoprotective, antioxidant, anti-tumor and other activities. It ameliorates human hepatocellular carcinoma by modulating the activities of NF-κB(p65), COX... | |||
T5099 | Gefapixant | RO 4926219,AF219,MK-7264 | P2X Receptor |
Gefapixant (AF219) is a P2X3 receptor (P2X3R) antagonist with IC50 of ~30 nM at recombinant hP2X3 homotrimers and 100-250 nM at hP2X2/3 heterotrimeric receptors. | |||
T6856 | Halofuginone | Tempostatin,empostatin,RU-19110 | Calcium Channel , DNA/RNA Synthesis , Sodium Channel , Parasite , TGF-beta/Smad |
Halofuginone (RU-19110), the competitive inhibitor of prolyl-tRNA synthetase(Ki=18.3 nM), could also down-regulate Smad3 and blocked TGF-β signaling at 10 ng/ml in the mammal. | |||
T3524 | Halofuginone hydrobromide | Tempostatin,RU-19110 (hydrobromide),Stenorol | Others , Calcium Channel , DNA/RNA Synthesis , Sodium Channel , Parasite , TGF-beta/Smad |
Halofuginone specifically inhibits collagen type I gene expression and matrix metalloproteinase 2 (MMP-2) gene expression, which may result in the suppression of angiogenesis, tumor stromal cell development, and tumor ce... | |||
T7475 | S-Adenosyl-L-methionine | AdoMet,Ademetionine,SAMe,S-Adenosyl methionine | Others , Endogenous Metabolite |
S-Adenosyl-L-methionine (Ademetionine) is an intermediate metabolite of methionine,for treatment of primary biliary cirrhosis and major depressive disorder. |