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Fenbufen

Name: Fenbufen
Brand: TargetMol
SKU: T0859
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0859Cas No. 36330-85-5

Alias Lederfen, CL-82204

Fenbufen (Lederfen) is a non-steroidal anti-inflammatory drug used primarily to treat inflammation in osteoarthritis, ankylosing spondylitis, and tendinitis. It can also be used to relieve backaches, sprains, and fractures. Fenbufen is available as a capsule or tablet sold with the brand names Cepal, Cinopal, Cybufen, Lederfen, and Reugast. Fenbufen acts by preventing cyclooxygenase from producing prostaglandins which can cause inflammation.

Fenbufen

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Purity: 98.46%

Catalog No. T0859Alias Lederfen, CL-82204Cas No. 36330-85-5

Pack Size	Price	USA Warehouse	Global Warehouse
200 mg	$30	In Stock	In Stock
500 mg	$40	-	In Stock
1 g	$52	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:98.46%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	Fenbufen (Lederfen) is a non-steroidal anti-inflammatory drug used primarily to treat inflammation in osteoarthritis, ankylosing spondylitis, and tendinitis. It can also be used to relieve backaches, sprains, and fractures. Fenbufen is available as a capsule or tablet sold with the brand names Cepal, Cinopal, Cybufen, Lederfen, and Reugast. Fenbufen acts by preventing cyclooxygenase from producing prostaglandins which can cause inflammation.
Targets&IC50	Caspase-4:0.57 μM, ATP systhesis:0.88 μM(Ki), COX-1:3.9 μM, COX-2:8.1 μM, Caspase-5:0.87 μM, Caspase-3:1.2 μM, Caspase-9:0.76 μM, Caspase-1:4.4 μM
In vivo	Fenbufen and its metabolites could be involved in mitochondrial toxicity through inhibition of ATP synthesis[1]. Fenbufen inhibited prostaglandin release by 80% and reduced rates of protein synthesis in normal muscle and in muscle undergoing hypertrophy in response to tenotomy of a synergist[3].
Synonyms	Lederfen, CL-82204

Chemical Properties

Molecular Weight	254.28
Formula	C₁₆H₁₄O₃
Cas No.	36330-85-5
Smiles	C(CCC(O)=O)(=O)C1=CC=C(C=C1)C2=CC=CC=C2
Relative Density.	1.1565 g/cm3 (Estimated)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 47 mg/mL (184.84 mM), Sonication is recommended.

DMSO: 47 mg/mL (184.84 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

In Vivo Formulation

10% DMSO+90% Corn Oil: 2 mg/mL (7.87 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.9327 mL	19.6634 mL	39.3267 mL	196.6336 mL
5 mM	0.7865 mL	3.9327 mL	7.8653 mL	39.3267 mL
10 mM	0.3933 mL	1.9663 mL	3.9327 mL	19.6634 mL
20 mM	0.1966 mL	0.9832 mL	1.9663 mL	9.8317 mL
50 mM	0.0787 mL	0.3933 mL	0.7865 mL	3.9327 mL
100 mM	0.0393 mL	0.1966 mL	0.3933 mL	1.9663 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc