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Fenbufen

Catalog No. T0859 CAS 36330-85-5

Synonyms: 芬布芬, CL-82204, Lederfen

Fenbufen is a non-steroidal anti-inflammatory drug used primarily to treat inflammation in osteoarthritis, ankylosing spondylitis, and tendinitis. It can also be used to relieve backaches, sprains, and fractures. Fenbufen is available as a capsule or tablet sold with the brand names Cepal, Cinopal, Cybufen, Lederfen, and Reugast. Fenbufen acts by preventing cyclooxygenase from producing prostaglandins which can cause inflammation.

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Fenbufen, CAS 36330-85-5

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Fenbufen is a non-steroidal anti-inflammatory drug used primarily to treat inflammation in osteoarthritis, ankylosing spondylitis, and tendinitis. It can also be used to relieve backaches, sprains, and fractures. Fenbufen is available as a capsule or tablet sold with the brand names Cepal, Cinopal, Cybufen, Lederfen, and Reugast. Fenbufen acts by preventing cyclooxygenase from producing prostaglandins which can cause inflammation.
Targets&IC50	ATP systhesis:0.88 μM(Ki)
In vivo	Fenbufen and its metabolites could be involved in mitochondrial toxicity through inhibition of ATP synthesis[1]. Fenbufen inhibited prostaglandin release by 80% and reduced rates of protein synthesis in normal muscle and in muscle undergoing hypertrophy in response to tenotomy of a synergist[3].

Synonyms	芬布芬, CL-82204, Lederfen
Molecular Weight	254.285
Formula	C16H14O3
CAS No.	36330-85-5

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

Ethanol: 47 mg/mL (184.8 mM)

DMSO: 47 mg/mL (184.8 mM)

H2O: <1 mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Syed M, et al. Toxicol In Vitro. 2016, 31:23-29. 2. Naora K, et al. J Antimicrob Chemother. 1992, 30(5):673-683. 3. Palmer RM, et al. Br J Pharmacol. 1990, 101(4):835-838.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Compound Library Anti-Cancer Metabolism Compound Library Inhibitor Library Ion Channel Inhibitor Library Immunology/Inflammation Compound Library Drug Repurposing Compound Library Anti-Cancer Approved Drug Library Anti-COVID-19 Compound Library Approved Drug Library Anti-Cancer Drug Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

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Keywords

Fenbufen 36330-85-5 蛋白酶体凋亡离子通道免疫与炎症神经科学 ATPase Caspase COX anti-inflammatory tendinitis CL-82204 Lederfen analgetic CL82204 Inhibitor inhibit CL 82204 antipyretic ankylosing spondylitis antirheumatic osteoarthritis Cyclooxygenase inhibitor

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