Powder: -20°C for 3 years | In solvent: -80°C for 1 year
MMP13-IN-3 is <1000 selective over other MMPs. MMP13-IN-3 is an effective, selective, and orally active MMP-13 inhibitor (IC50=1 nM) for the potential treatment of osteoarthritis.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 98.00 | |
5 mg | In stock | $ 247.00 | |
10 mg | In stock | $ 397.00 | |
25 mg | In stock | $ 663.00 | |
50 mg | In stock | $ 945.00 | |
100 mg | In stock | $ 1,280.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 272.00 |
Description | MMP13-IN-3 is >1000 selective over other MMPs. MMP13-IN-3 is an effective, selective, and orally active MMP-13 inhibitor (IC50=1 nM) for the potential treatment of osteoarthritis. |
Targets&IC50 | MMP-10:16 μM, MMP-2:18 μM, MMP-13:1 nM, MMP-9:8.9 μM, MMP-14:8.3 μM |
In vitro | MMP13-IN-3 inhibits MMP-2, MMP-9, MMP-10 and MMP-14 with IC50s of 18, 8.9, 16 and 8.3 μM, respectively. MMP13-IN-3 is effective in a full-length MMP-13 collagen degradation assay (11 nM) and is able to inhibit the degradation of bovine nasal cartilage (IC50: 31 nM) [1]. |
In vivo | MMP13-IN-3 has short terminal elimination half-life (t1/2=0.47 h for rat (1 mg/kg, i.v.) and rat (10 mg/kg, orally), respectively). MMP13-IN-3 reaches micromolar plasma levels (AUC=1109±64 nM h/mL) when dosed orally at 10 mg/kg or i.v. 1 mg/kg. It displays modest clearance (CL=34 mL/min/kg), and shows acceptable bioavailability (39%). The Vss is quite low at 0.26 mL/mi/kg rat pharmacokinetic profile [1]. |
Molecular Weight | 446.46 |
Formula | C24H22N4O5 |
CAS No. | 1222173-37-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (223.98 mM), Need ultrasonic and warming and heat to 60°C
You can also refer to dose conversion for different animals. More
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MMP13-IN-3 1222173-37-6 Proteases/Proteasome MMP inhibit osteoarthritis Inhibitor MMP13 IN 3 Matrix metalloproteinases MMP-13-IN-3 MMP13IN3 MMP-13 inhibitor