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Parecoxib

Catalog No. T1780 CAS 198470-84-7

Synonyms: SC 69124, Vorth-P, Valus-P

Parecoxib (SC 69124) is an effective and selective COX-2 inhibitor.

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Parecoxib, CAS 198470-84-7

Pack Size	Availability	Price/USD
5 mg	In stock	$ 30.00
10 mg	In stock	$ 41.00
25 mg	In stock	$ 64.00
50 mg	In stock	$ 108.00
100 mg	In stock	$ 178.00
200 mg	In stock	$ 293.00
500 mg	In stock	$ 491.00
1 mL * 10 mM (in DMSO)	In stock	$ 54.00

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Purity: 99.9%

Purity: 99.78%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Parecoxib (SC 69124) is an effective and selective COX-2 inhibitor.

In vivo

Parecoxib, a selected cyclooxygenase-2 inhibitor, ameliorates neurologic deficits in the behavior studies and brain damage, including neuronal death, and brain edema in the MCP-1 and NeuN immunostaining in rats subjected to SAH(Subarachnoid Hemorrhage). Parecoxib is able to reduce early COX2 expression via inhibiting cJNK (p55) expression (dose-dependently), reduce IL-1β, IL-6 and MCP-1( at 2000 ug/kg/day at the time point of 24hr and 72hr after the induction of SAH), IL-8 (of the dosage of 2000 ug/kg/day at 24hr after the induction of SAH), and also reduce cleaved caspase-1 (at 1000 and 2000 ug/kg/day) and Caspase-9a (at 2000 ug/kg/day). Parecoxib reduces the NMDAR-1, and NMDAR-2a (at 1000 and 2000 ug/kg) after the induction of SAH[2].

Synonyms	SC 69124, Vorth-P, Valus-P
Molecular Weight	370.42
Formula	C19H18N2O4S
CAS No.	198470-84-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 2 mg/mL (5.4 mM)

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 69 mg/mL (186.3 mM)

References and Literature

1. Meunier A, et al. Arch Orthop Trauma Surg. 2006, 126(7):433-6. 2. Chih-Zen Chang, et al. Journal of Neurology & Neurophysiology. 2015.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Clinical Compound Library Anti-Cancer Drug Library Anti-Cancer Active Compound Library Anti-Cancer Approved Drug Library Inhibitor Library EMA Approved Drug Library Anti-Neurodegenerative Disease Compound Library Drug Repurposing Compound Library Neuronal Signaling Compound Library Bioactive Compounds Library Max

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Parecoxib 198470-84-7 Immunology/Inflammation Neuroscience COX osteoarthritis POCD rheumatoid arthritis pain Cyclooxygenase cognitive dysfunction postoperative SC 69124 SC-69124 coxibs analgesia SC69124 Inhibitor inhibit Vorth-P chronic inflammatory condition Valus-P inhibitor

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