nonselective — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T8976	PD-089828		EGFR , FGFR , PDGFR , Src
	PD 089828 is a competitive inhibitor of the receptor tyrosine kinases FGFR1, PDGFRβ, and EGFR (IC50s = 0.15, 1.76, and 5.47 µM, respectively) and a noncompetitive inhibitor of the nonreceptor tyrosine kinase c-Src (IC50 ...		EGFR , FGFR , PDGFR , Src
T27606	Indantadol HCl	CHF-3381,CMP-3381,GT-3381,V-3381,CNP-3381,Indantadol	MAO , NMDAR
	Indantadol HCl (CHF-3381) is a NMDA antagonist and nonselective MAO inhibitor.		MAO , NMDAR
T12444	Phentolamine Analogue 1		Adrenergic Receptor
	Phentolamine Analogue 1 is an analogue of phentolamine. Phentolamine is a nonselective antagonist of α-adrenergic.		Adrenergic Receptor
T6387	Ampiroxicam	CP 65703,Flucam	COX
	Ampiroxicam (Flucam) is a nonselective cyclooxygenase inhibitor uesd as anti-inflammatory drug.		COX
T8738	LUN42518 HCl 47142-51-8(free base)		Adrenergic Receptor
	LUN42518 HCl is an analogue of phentolamine. Phentolamine is a nonselective alpha-adrenergic antagonist.		Adrenergic Receptor
T0804	Pilocarpine Hydrochloride	NSC 5746 HCl,Pilocarpine HCl,(+)-Pilocarpine hydrochloride	AChR
	Pilocarpine Hydrochloride (NSC 5746 HCl) , a nonselective muscarinic acetylcholine receptor agonist, is utilized to produce an experimental model of epilepsy.		AChR
T10355	Apyramide		COX
	Apyramide is an anti-inflammatory agent (NSAID) and behaves as a prodrug of indomethacin. Indomethacin is a potent, blood-brain permeable and nonselective inhibitor of COX1 and COX2.		COX
T64373	CDK1-IN-2	cdk1 inhibitor 2	CDK
	CDK1-IN-2 (cdk1 inhibitor 2) is a CDK1 inhibitor with IC50 of 5.8 μM. A broad-spectrum kinase profiling of CDK1-IN-2 revealed nonselective inhibition of several kinases.		CDK
T1681	Aminophylline	Phyllocontin	PDE , Adenosine Receptor
	Aminophylline (Phyllocontin) is a competitive nonselective phosphodiesterase inhibitor giving a bronchodilatory effect.		PDE , Adenosine Receptor
T3951	NSC632839	F6,Ubiquitin Isopeptidase Inhibitor II	DUB
	NSC-632839 (Ubiquitin Isopeptidase Inhibitor II) is a nonselective isopeptidase inhibitor, which inhibits USP2 (EC50: 45±4 μM), USP7 (EC50: 37±1 μM), and SENP2 (EC50: 9.8±1.8 μM).		DUB
T21389	Enprofylline	Enprofilina,3-propylxanthine,3-n-Propylxanthine,Enprofyllinum	Others
	Enprofylline (Enprofilina), a bronchodilator, acts primarily as a competitive nonselective phosphodiesterase inhibitor. Enprofylline is used in asthma, chronic obstructive pulmonary disease, and in the management of sick...		Others
T1889	CP-640186	CP 640186	Acetyl-CoA Carboxylase
	CP-640186 is an isozyme-nonselective Acetyl-CoA carboxylase (ACCase) inhibitor. The IC50s of CP-640186(CP 640186) is 53 nM and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2 respectively.		Acetyl-CoA Carboxylase
T1282	Carteolol hydrochloride	Arteoptic,Abbott-43326,OPC-1085 hydrochloride,Carteolol HCl,Mikelan	Adrenergic Receptor
	Carteolol hydrochloride (Abbott-43326) is a synthetic quinolinone derivative, antihypertensive Carteolol Hydrochloride is a nonselective beta-adrenoceptor blocking agent for beta-1 and beta-2 receptors with no membrane-s...		Adrenergic Receptor
T3622	CP-640186 hydrochloride	CP 640186 HCl	Acetyl-CoA Carboxylase
	CP-640186 hydrochloride (CP 640186 HCl) is an isozyme-nonselective acetyl-CoA carboxylase (ACC) inhibitor, including rat liver ACC1 (IC50: 53 nM) and rat skeletal muscle ACC2 (IC50: 61 nM); with higher metabolic stabilit...		Acetyl-CoA Carboxylase
T2137	Ibudilast	AV-411,KC-404,MN-166	PDE
	Ibudilast (MN-166)(KC-404;AV-411;MN-166) is a relatively nonselective phosphodiesterase inhibitor. It is approved for use as an anti-inflammatory in Japan.		PDE
T20898	(R)-Propranolol hydrochloride	Dexpropranolol hydrochloride,(R)-(+)-Propranolol	Adrenergic Receptor
	(R)-Propranolol hydrochloride (Dexpropranolol hydrochloride) is the less active enantiomer of the anti-adrenoceptor (β-adrenoceptor) antagonist propranolol. Propranolol is a nonselective β-adrenergic receptor (βAR) antag...		Adrenergic Receptor
T1275	Phentolamine mesylate	Phentolamine methanesulfonate,Phentolamine mesilate	Adrenergic Receptor
	Phentolamine mesylate (Phentolamine methanesulfonate) is a nonselective alpha-adrenergic antagonist. It is used in the treatment of hypertension and hypertensive emergencies, pheochromocytoma, vasospasm of RAYNAUD DISEAS...		Adrenergic Receptor
T4612	NS309		EGFR , Potassium Channel , HER
	NS309 is a nonselective activator of small- and intermediate-conductance Ca2+-activated K+ (SK/KCa2 and IK/KCa3.1) channels (EC50s range from 0.12-1.2 µM for SK channels and 10-90 nM for IK channels). It can also activat...		EGFR , Potassium Channel , HER
TP1910L1	CALP1 acetate	CALP1 acetate(145224-99-3 free base)	CaMK
	CALP1 acetate is a calmodulin (CaM) agonist (Kd of 88 µM) that binds to the CaM EF-hand/Ca2+-binding site. CALP1 blocks calcium influx and apoptosis (IC50 of 44.78 µM) by inhibiting the open of calcium channel. CALP1 blo...		CaMK
T38240	2,6-Dichlorodiphenylamine		Antibacterial
	2,6-Dichlorodiphenylamine is an analogue of Diclofenac Sodium and has anti-Candida albicans activity. Diclofenac Sodium is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1...		Antibacterial