Powder: -20°C for 3 years | In solvent: -80°C for 2 years
Ampiroxicam is a nonselective cyclooxygenase inhibitor uesd as anti-inflammatory drug.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
10 mg | In stock | $ 54.00 | |
25 mg | In stock | $ 98.00 | |
50 mg | In stock | $ 142.00 | |
100 mg | In stock | $ 229.00 | |
200 mg | In stock | $ 342.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 56.00 |
Description | Ampiroxicam is a nonselective cyclooxygenase inhibitor uesd as anti-inflammatory drug. |
In vitro | Ampiroxicam (<150 μM) dose-dependently decreases the proliferation of Panc-1 cells. [1] Ampiroxicam (50 μM) results in decreased expression of Sp1, Sp3, Sp4, and VEGFR1 proteins in Panc-1 cells and L3.6pl cells as determined by Western blot analysis. Ampiroxicam (50 μM) results in increased phosphorylation of MAPK1/2 in Panc-1 cells and L3.6pl cells. [2] |
In vivo | Ampiroxicam inhibits the stretching response in mice induced by phenylbenzoquinone (PBQ) with maximum protective effect (MPE) of 2 mg/kg. Ampiroxicam inhibits swelling in a dose-responsive manner in the rat foot edema (RFE) assay with ED50 of 28 mg/kg at single oral dose and 7.8 mg/kg at 5 daily oral dose. Ampiroxicam blocks primary and secondary lesion development in rat adjuvant arthritis with ED50 of 2.2 mg/kg and 0.5 mg/kg, respectively. Ampiroxicam (3.2 mg/kg) leads to a plasma concentration of 12 μg/mL at a Tmax of 2 hours for piroxicam derived from ampiroxicam in rats. [3] Ultraviolet-A (UVA)-irradiated 1% Ampiroxicam sensitized in guinea pigs shows positive reaction in the patch testing to UVA-irradiated 1% Ampiroxicam and 1% thiosalicylate (TOS). Concentration of Ampiroxicam is easily reduced by the increase in UVA irradiation doses, as compared with that of piroxicam. [4] |
Cell Research | Panc-1 cells are plated in DME/F12 medium with 5% fetal bovine serum and treated on the next day with vehicle (0.1% DMSO) or various concentrations of Ampiroxicam. Cells are counted at the indicated times with a Coulter Z1 cell counter. Each experiment is done in triplicate, and results are expressed as means, with error bars representing 95% confidence intervals (CIs).(Only for Reference) |
Synonyms | CP 65703, Flucam |
Molecular Weight | 447.46 |
Formula | C20H21N3O7S |
CAS No. | 99464-64-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
Ethanol: <1 mg/mL
H2O: <1 mg/mL
DMSO: 83 mg/mL (185.5 mM)
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Ampiroxicam 99464-64-9 Immunology/Inflammation Neuroscience COX inhibit CP65703 Cyclooxygenase CP-65703 Inhibitor CP 65703 Flucam inhibitor