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Ampiroxicam

Catalog No. T6387 CAS 99464-64-9

Synonyms: CP 65703, Flucam

Ampiroxicam is a nonselective cyclooxygenase inhibitor uesd as anti-inflammatory drug.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Ampiroxicam, CAS 99464-64-9

Pack Size	Availability	Price/USD
10 mg	In stock	$ 54.00
25 mg	In stock	$ 98.00
50 mg	In stock	$ 142.00
100 mg	In stock	$ 229.00
200 mg	In stock	$ 342.00
1 mL * 10 mM (in DMSO)	In stock	$ 56.00

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Purity: 99.2%

Purity: 99.15%

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Description	Ampiroxicam is a nonselective cyclooxygenase inhibitor uesd as anti-inflammatory drug.
In vitro	Ampiroxicam (<150 μM) dose-dependently decreases the proliferation of Panc-1 cells. [1] Ampiroxicam (50 μM) results in decreased expression of Sp1, Sp3, Sp4, and VEGFR1 proteins in Panc-1 cells and L3.6pl cells as determined by Western blot analysis. Ampiroxicam (50 μM) results in increased phosphorylation of MAPK1/2 in Panc-1 cells and L3.6pl cells. [2]
In vivo	Ampiroxicam inhibits the stretching response in mice induced by phenylbenzoquinone (PBQ) with maximum protective effect (MPE) of 2 mg/kg. Ampiroxicam inhibits swelling in a dose-responsive manner in the rat foot edema (RFE) assay with ED50 of 28 mg/kg at single oral dose and 7.8 mg/kg at 5 daily oral dose. Ampiroxicam blocks primary and secondary lesion development in rat adjuvant arthritis with ED50 of 2.2 mg/kg and 0.5 mg/kg, respectively. Ampiroxicam (3.2 mg/kg) leads to a plasma concentration of 12 μg/mL at a Tmax of 2 hours for piroxicam derived from ampiroxicam in rats. [3] Ultraviolet-A (UVA)-irradiated 1% Ampiroxicam sensitized in guinea pigs shows positive reaction in the patch testing to UVA-irradiated 1% Ampiroxicam and 1% thiosalicylate (TOS). Concentration of Ampiroxicam is easily reduced by the increase in UVA irradiation doses, as compared with that of piroxicam. [4]
Cell Research	Panc-1 cells are plated in DME/F12 medium with 5% fetal bovine serum and treated on the next day with vehicle (0.1% DMSO) or various concentrations of Ampiroxicam. Cells are counted at the indicated times with a Coulter Z1 cell counter. Each experiment is done in triplicate, and results are expressed as means, with error bars representing 95% confidence intervals (CIs).(Only for Reference)

Synonyms	CP 65703, Flucam
Molecular Weight	447.46
Formula	C20H21N3O7S
CAS No.	99464-64-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 2 years

Solubility Information

Ethanol: <1 mg/mL

H2O: <1 mg/mL

DMSO: 83 mg/mL (185.5 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Abdelrahim M, et al. J Natl Cancer Inst, 2006, 98(12), 855-868. 2. Abdelrahim M, et al. Cancer Res, 2007, 67(7), 3286-3294. 3. Carty TJ, et al. Agents Actions, 1993, 39(3-4), 157-165. 4. Sasaki T, et al. J Dermatol Sci, 1999, 21(3), 170-175.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Drug Library Anti-Aging Compound Library Bioactive Compounds Library Max Approved Drug Library Neuronal Signaling Compound Library Anti-Cancer Compound Library Anti-Fibrosis Compound Library Inhibitor Library FDA-Approved & Pharmacopeia Drug Library Immunology/Inflammation Compound Library

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Keywords

Ampiroxicam 99464-64-9 Immunology/Inflammation Neuroscience COX inhibit CP65703 Cyclooxygenase CP-65703 Inhibitor CP 65703 Flucam inhibitor

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