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CP-640186 hydrochloride

Catalog No. T3622   CAS 591778-70-0
Synonyms: CP 640186 HCl

CP-640186 hydrochloride (CP 640186 HCl) is an isozyme-nonselective acetyl-CoA carboxylase (ACC) inhibitor, including rat liver ACC1 (IC50: 53 nM) and rat skeletal muscle ACC2 (IC50: 61 nM); with higher metabolic stability than CP-610431.

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CP-640186 hydrochloride Chemical Structure
CP-640186 hydrochloride, CAS 591778-70-0
Pack Size Availability Price/USD Quantity
1 mg In stock $ 31.00
2 mg In stock $ 44.00
5 mg In stock $ 72.00
10 mg In stock $ 117.00
25 mg In stock $ 247.00
50 mg In stock $ 397.00
100 mg In stock $ 589.00
1 mL * 10 mM (in DMSO) In stock $ 83.00
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Purity: 99.04%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description CP-640186 hydrochloride (CP 640186 HCl) is an isozyme-nonselective acetyl-CoA carboxylase (ACC) inhibitor, including rat liver ACC1 (IC50: 53 nM) and rat skeletal muscle ACC2 (IC50: 61 nM); with higher metabolic stability than CP-610431.
Targets&IC50 ACC2:61 nM, ACC1:53 nM
Kinase Assay Aconitase activities are determined by homogenization of mouse brain tissues on ice at 10% w/v in CellLytic MT Mammalian Tissue Lysis/Extraction buffer, followed by centrifugation at 800×g?for 10?min at 4°C. Tissue lysates (50?μL) are then added to 200?μL of substrate mix (50?mM Tris/HCl pH 7.4, 0.4?mM NADP, 5?mM Na citrate, 0.6?mM MgCl2, 0.1% (v/v) Triton X-100 and 1U isocitrate dehydrogenase) and the reactions are incubated at 37°C for 15?min, followed by spectrophotometric absorbance measurements every minute for 15?min at 340?nm 37°C to determine the reaction slope. Aconitase activities of mouse brain tissues are then normalized to citrate synthase activities, which are determined using a citrate synthase assay kit.
Synonyms CP 640186 HCl
Molecular Weight 522.08
Formula C30H36ClN3O3
CAS No. 591778-70-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (95.77 mM)

TargetMolReferences and Literature

1. Harwood HJ Jr, et al. J Biol Chem. 2003 Sep 26;278(39):37099-111. ; 2. Yamashita T, et al. Bioorg Med Chem Lett. 2011 Nov 1;21(21):6314-8.;

Related compound libraries

This product is contained In the following compound libraries:
NO PAINS Compound Library Lipid Metabolism Compound Library Metabolism Compound Library Inhibitor Library Bioactive Compounds Library Max Bioactive Compound Library Anti-Metabolism Disease Compound Library Anti-Cardiovascular Disease Compound Library Anti-Hypertension Compound Library Anti-Obesity Compound Library

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Keywords

CP-640186 hydrochloride 591778-70-0 Metabolism Acetyl-CoA Carboxylase ACC, Acetyl Coenzyme A Carboxylase CP 640186 muscle fatty acid oxidation CP 640186 Hydrochloride CP640186 hydrochloride C2C12 HepG2 H460 CP640186 human fibroblasts inhibit CP-640186 Hydrochloride CP640186 Hydrochloride CP 640186 HCl muscle strips CP-640186 Inhibitor CP 640186 hydrochloride inhibitor

 

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