hypersensitivity — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T9685	DS-1971a		Sodium Channel
	DS-1971a is a highly potent and selective NaV1.7 inhibitor. DS-1971a exhibits a favorable toxicological profile and analgesic effects.		Sodium Channel
T4563	Thonzylamine	neohetramine	Histamine Receptor
	Thonzylamine (neohetramine) is an antihistamine and anticholinergic drug. It is available as combination products with Clofedanol or Phenylephrine for temporary relief of symptoms of common cold, hay fever (allergic rhin...		Histamine Receptor
T5491	GSK3179106		c-RET
	GSK3179106 is RET kinase inhibitor with an IC50 of 0.4 nM		c-RET
T14984	CLP257		Potassium Channel
	CLP257 is a selective K+-Cl− cotransporter KCC2 activator (EC50: 616 nM) and it is inactive against NKCC1, GABAA receptors, KCC1, KCC3 or KCC4. CLP257 alleviates hypersensitivity in rats with neuropathic painc and it al...		Potassium Channel
T14127	Adenosine A1 receptor activator T62		Adenosine Receptor
	Adenosine A1 receptor activator T62 is an allosteric enhancer of adenosine A1 receptor, and it produces antinociception in animal models of acute pain and also reduces hypersensitivity in models of inflammatory and nerve...		Adenosine Receptor
T1824	TGR5 Receptor Agonist		GPCR19
	TGR5 is a potent TGR5(GPCR19) agonist.		GPCR19
T21472	Dimethindene maleate	UNII-6LL60J9E0O,SU 6518,SU-6518	Histamine Receptor
	Dimethindene maleate (SU 6518) is a histamine H1 antagonist and can be used in studies about the treatment of hypersensitivity reactions, pruritus and rhinitis.		Histamine Receptor
T124635	Cyclo(L-Pro-L-Ile)
	Cyclo(L-Pro-L-Ile) is a bis-ketopiperazine from Bacillus thuringiensis that induces a moderate hypersensitivity reaction and can be used to study pine wilt.
T36478	BI-6901		CCR
	BI-6901 is a CCR10 antagonist. In a mouse model of DNFB exposure hypersensitivity, BI 6901 displays its anti-inflammatory response in a dose-dependent manner.		CCR
T15192	Eact		Chloride channel
	Eact is a selective and potent TMEM16A activator. It directly activates the TRPV1 channels in sensory nociceptors. Which also produces itch, acute nociception and thermal hypersensitivity.		Chloride channel
T16448	PD173212		Calcium Channel
	PD 173212 is a blocker that blocks N-type voltage sensitive calcium channel (Cav2.2). PD173212 (0.0017-1.7 μmol/kg, Intraperitoneal Injection.) dose-dependently reduced DNBS-induced visceral hypersensitivity in mice.		Calcium Channel
T77340L	AB21 HCl		Sigma receptor
	AB21 HCl is a selective antagonist of the σ1 receptor, with Kis of 13 nM for σ1 receptor and 102 nM for σ2 receptor. AB21 HCl is known for its ability to reduce mechanical hypersensitivity.		Sigma receptor
T0690	Quinine		Potassium Channel , Platelet aggregation , Parasite
	Quinine is a natural cinchona alkaloid that has been used for centuries in the prevention and therapy of malaria. Quinine is also used for idiopathic muscle cramps. Quinine therapy has been associated with rare instances...		Potassium Channel , Platelet aggregation , Parasite
T0330	Diphenhydramine hydrochloride	Diphenhydramine HCl,DPH	Histamine Receptor
	Diphenhydramine hydrochloride (DPH) is a histamine H1 antagonist used as an antitussive and antiemetic. It is also used for pruritus and dermatoses, for hypersensitivity reactions, as an antiparkinson, a hypnotic, and as...		Histamine Receptor
T16240	N,N'-Diacetyl-L-cystine	(Ac-Cys-OH)2,DiNAC	Others
	N,N'-Diacetyl-L-cystine (DiNAC) is the disulphide dimer of N-acetylcysteine with immunomodulating properties. N,N'-diacetyl-L-cystine also has antiatherosclerotic effects in Watanabe-heritable hyperlipidemic rabbit (WHHL...		Others
T0186	Docetaxel trihydrate	RP-56976 (Trihydrate),RP56976 (NSC 628503) Trihydrate	Apoptosis , BCL , Microtubule Associated
	Docetaxel trihydrate (RP-56976 Trihydrate) is an antineoplastic agent that has a unique mechanism of action as an inhibitor of cellular mitosis and that currently plays a central role in the therapy of many solid tumor i...		Apoptosis , BCL , Microtubule Associated
T3627	IQ-1S free acid	IQ-1,IQ-1S,IQ-1S (free acid)	NF-κB , JNK
	IQ-1S free acid (IQ-1S) is an effective and specific c-Jun N-Terminal Kinase Inhibitor. IQ-1S inhibits murine delayed-type hypersensitivity. IQ-1S can reduce inflammation and cartilage loss associated with CIA and can se...		NF-κB , JNK
T19839	Oxatomide	Oxatomida	P2X Receptor , Calcium Channel , 5-HT Receptor , Histamine Receptor
	Oxatomide (Oxatomida) is a potent and orally active dual H1 histamine receptor and P2X7 receptor antagonist with antihistamine and antiallergic activity.Oxatomide can be used to block ATP-induced currents in the human P2...
T15096	Delgocitinib	JTE-052,Corectim（Delgocitinib）	Tyrosine Kinases , JAK
	Delgocitinib (JTE-052) is a specific JAK (Janus kinase) inhibitor with IC50 values of 2.8, 2.6, 13, and 58 nM for JAK1, JAK2, JAK3, and Tyk2 respectively. Delgocitinib is involved in various inflammatory and autoimmune d...		Tyrosine Kinases , JAK
T24771	SCH-336	SCH336,SCH 336	Cannabinoid Receptor
	SCH-336 is a CB2 receptor agonist (Ki-1.8 nM, EC50-2 nM) with effective, selective, and oral activity. SCH-336 is also bioactive against CB1 receptor, and is 100 times more selective to CB2 receptor than CB1. SCH-336 red...		Cannabinoid Receptor