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Oxatomide

Catalog No. T19839 CAS 60607-34-3

Synonyms: Oxatomida

Oxatomide (Oxatomida) is a potent and orally active dual H1 histamine receptor and P2X7 receptor antagonist with antihistamine and antiallergic activity.Oxatomide can be used to block ATP-induced currents in the human P2X7 receptor with an IC50 value of 0.95 μM.Oxatomide has an inhibitory effect on ATP-induced Ca2+ inward currents with an IC50 value of 0.43 μM.Oxatomide inhibits 5-hydroxytryptamine. Oxatomide inhibits 5-hydroxytryptamine with an IC50 of 0.43 μM.Oxatomide is used in the treatment of immune system diseases and in the study of hypersensitivity reactions.

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Oxatomide, CAS 60607-34-3

Pack Size	Availability	Price/USD
1 mg	In stock	$ 41.00
5 mg	In stock	$ 97.00
10 mg	In stock	$ 163.00
25 mg	In stock	$ 313.00
50 mg	In stock	$ 497.00
100 mg	In stock	$ 788.00
500 mg	In stock	$ 1,590.00
1 mL * 10 mM (in DMSO)	In stock	$ 107.00

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Purity: 98.93%

Purity: 98.61%

Biological Description

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Storage & Solubility Information

Description

In vitro

Oxatomide almost completely blocks the ATP-induced current in human P2X7 receptors (IC50 of 0.95 μM). Oxatomide inhibits ATP-induced Ca2+ influx with an IC50 value of 0.43 μM and also inhibits serotonin.[1]

Synonyms	Oxatomida
Molecular Weight	426.55
Formula	C27H30N4O
CAS No.	60607-34-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 170.62 mg/mL (400 mM)

References and Literature

1. Yoshida K, et al. P2X7 receptor antagonist activity of the anti-allergic agent oxatomide. Eur J Pharmacol. 2015;767:41-51. 2. Ohmori K, et al. Pharmacological studies on oxatomide (KW-4354). (7) Antagonistic effects on chemical mediators. Nihon Yakurigaku Zasshi. 1983;81(5):399-409. 3. Raschi E, et al. The Contribution of National Spontaneous Reporting Systems to Detect Signals of Torsadogenicity: Issues Emerging from the ARITMO Project. Drug Saf. 2016 Jan;39(1):59-68. 4. Curtin Whelan L, Geary M, Sweetman P. Development and validation of a rapid liquid chromatographic method for the determination of oxatomide and its related impurities. J Chromatogr Sci. 2014 Nov-Dec;52(10):1267-72.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Approved Drug Library Anti-Cancer Drug Library Anti-Cancer Clinical Compound Library GPCR Compound Library Membrane Protein-targeted Compound Library Drug Repurposing Compound Library FDA-Approved & Pharmacopeia Drug Library Approved Drug Library Bioactive Compound Library Neurotransmitter Receptor Compound Library

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Keywords

Oxatomide 60607-34-3 GPCR/G Protein Immunology/Inflammation Membrane transporter/Ion channel Metabolism Neuroscience Calcium Channel P2X Receptor 5-HT Receptor Histamine Receptor Oxatomida inhibitor inhibit

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