half-life — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T6446	Clevudine	L-FMAU,Levovir	HBV , DNA/RNA Synthesis
	Clevudine (Levovir) is a synthetic pyrimidine analogue with activity against hepatitis B virus (HBV). Intracellularly, clevudine is phosphorylated to its active metabolites, clevudine monophosphate and triphosphate. The ...		HBV , DNA/RNA Synthesis
T21474	Navuridine	AZddU,CS 87,CS-87,AzUrd,3'-Azido-2',3'-dideoxyuridine,AZdU	HIV Protease
	Navuridine (AZdU) is an oral active inhibitor of HIV reverse transcriptase with a relatively short half-life.		HIV Protease
T1223	Ceftriaxone sodium hydrate	Ceftriaxone Sodium Trihydrate,Ceftriaxone disodium hemiheptahydrate,Ceftriaxone sodium	Others , Antibacterial , Antibiotic
	Ceftriaxone sodium hydrate is a broad-spectrum cephalosporin antibiotic with a very long half-life and high penetrability to meninges, eyes and inner ears.		Others , Antibacterial , Antibiotic
T67905	GS-829845		JAK , Drug Metabolite
	GS-829845 is a JAK1 inhibitor, the main component of the active metabolite of Filgotinib, which is approximately 10-fold less potent and has a longer half-life than the parent.		JAK , Drug Metabolite
T33941	PF-03635659	PF03635659,PF 03635659	AChR
	PF-03635659 is a potent and long dissociative half-life muscarinic M3 antagonist (Ki: 0.2 nM) that shows potential for the treatment of chronic obstructive pulmonary disease (COPD).		AChR
T10392	Aspoxicillin		Anti-infection , Antibacterial
	Aspoxicillin, a broad-spectrum antimicrobial agent, demonstrates efficacy against 68 isolates of Actinobacillus pleuropneumoniae, with a minimum inhibitory concentration (MIC90) of <= 0.05 μg/ml. It exhibits a prolonged ...		Anti-infection , Antibacterial
T3967	Exendin-4	Exenatide,Exenatide Acetate	Glucagon Receptor
	Exendin-4 (Exenatide) is a glucagon-like peptide-1 receptor (GLP-1) agonist (IC50: 3.22 nM). Exenatide is a 39 amino acid peptide. Compared to GLP-1, exenatide has a longer half-life of 2.4 hours.		Glucagon Receptor
T71708	Minamestane		Aromatase
	Minamestane is a novel irreversible aromatase inhibitor.Minamestane induces time-dependent inhibition of human placental aromatase with a half-life of 4 minutes and a K of 59 nM.Minamestane has antitumor activity.		Aromatase
T1410	Torsemide	AC-4464,JDL-464,Torasemide	Na-K-Cl cotransporter
	Torsemide (AC-4464) is an anilinopyridine sulfonylurea belonging to the class of loop diuretics. Torsemide has a prolonged duration of action compared to other loop diuretics, is extensively protein bound in plasma and h...		Na-K-Cl cotransporter
T4814	(R)-5-Oxopyrrolidine-2-carboxylic acid	D-Pyroglutamic acid,(R)-(+)-2-Pyrrolidone-5-carboxylic acid	Others , Endogenous Metabolite
	(R)-5-Oxopyrrolidine-2-carboxylic acid (D-Pyroglutamic acid) is a cyclic derivative of glutamic acid, physiologically present in mammalian tissues. It has been shown that PCA releases GABA from the cerebral cortex and di...		Others , Endogenous Metabolite
T0195	Secnidazole	RP-14539,PM-185184	Antibiotic , Parasite
	Secnidazole (PM-185184) is a second-generation 5-nitroimidazole antimicrobial that is structurally related to other 5-nitroimidazoles including [DB00916] and [DB00911], but displays improved oral absorption and longer te...		Antibiotic , Parasite
T15300	Fluorofenidone	AKF-PD	Others
	Fluorofenidone (AKF-PD) attenuates the progression of renal interstitial fibrosis partly by suppressing NADPH oxidase and extracellular matrix (ECM) deposition via the PI3K/Akt signalling pathway. Fluorofenidone is an an...		Others
T4940	3-Methylhistamine dihydrochloride		Others , Endogenous Metabolite
	N tau-methylhistamine is one of the histamine metabolites. N tau-methylhistamine in plasma and urine is a good parameter for histamine release, and the determination of this histamine metabolite is generally less hampere...		Others , Endogenous Metabolite
T60919	SARS-CoV-2-IN-13		SARS-CoV
	SARS-CoV-2-IN-13 (compound 5) is an analogue of niclosamide. SARS-CoV-2-IN-13 is more stable than niclosamide in human plasma and liver S9 enzymes assay. SARS-CoV-2-IN-13 can improve bioavailability and half-life when ad...		SARS-CoV
T60538	SARS-CoV-2-IN-14	3',5-Dichlorosalicylanilide	SARS-CoV
	SARS-CoV-2-IN-14 is a potent and oral inhibitor of SARS-CoV-2 (IC50:0.39 μM), which is an analogue of niclosamide. SARS-CoV-2-IN-14 was more stable than niclosamide in the determination of human plasma and liver S9 enzym...		SARS-CoV
TP1895L1	KYL acetate(676657-00-4 free base)		Ephrin Receptor
	KYL acetate is an EphA4 receptor tyrosine kinase inhibitor (Kd = 0.8 μM); inhibits EphA4-EphrinA5 interactions (IC50 = 6.34 μM). Prevents AβO induced synaptic damage, dendritic spine loss and prevents the blocking of LTP...		Ephrin Receptor
T15117	Didesmethyl cariprazine		Dopamine Receptor , 5-HT Receptor
	Didesmethyl cariprazine, a metabolite of Cariprazine, is the major cyclic active part. Didesmethyl cariprazine has a long half-life of 1-3 weeks. Cariprazine is a potent D3 preference D3/D2 receptor partial agonist of do...		Dopamine Receptor , 5-HT Receptor
T3716	Rolapitant	SCH619734	Neurokinin receptor
	Rolapitant (SCH619734) Hydrochloride is the hydrochloride salt form of rolapitant, an orally bioavailable, centrally-acting, selective, neurokinin 1 receptor (NK1-receptor) antagonist with potential antiemetic activity. ...		Neurokinin receptor
T2671	Regadenoson	CVT-3146,Lexiscan	Adenosine Receptor
	Regadenoson (CVT-3146) is an adenosine derivative and selective A2A adenosine receptor agonist with coronary vasodilating activity. Upon administration, regadenoson selectively binds to and activates the A2A adenosine re...		Adenosine Receptor
T8947	Dasiglucagon acetate	dasiglucagon acetate(1544300-84-6 free base)	Others
	Dasiglucagon acetate is a novel glucagon analog for diabetic hypoglycemia therapy. Dasiglucagon acetate has demonstrated established solubility and stability in an aqueous formulation. Pharmacokinetics studies have shown...		Others