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Navuridine

Name: Navuridine
Brand: TargetMol
SKU: T21474
Price: 40 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T21474Cas No. 84472-85-5

Alias CS-87, CS 87, AzUrd, AZdU, AZddU, 3'-Azido-2',3'-dideoxyuridine

Navuridine (AZdU) is an oral active inhibitor of HIV reverse transcriptase with a relatively short half-life.

Navuridine

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Purity: 99.83%

Catalog No. T21474Alias CS-87, CS 87, AzUrd, AZdU, AZddU, 3'-Azido-2',3'-dideoxyuridineCas No. 84472-85-5

Navuridine (AZdU) is an oral active inhibitor of HIV reverse transcriptase with a relatively short half-life.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$40	-	In Stock
10 mg	$65	-	In Stock
25 mg	$133	-	In Stock
50 mg	$198	-	In Stock
100 mg	$313	-	In Stock
1 mL x 10 mM (in DMSO)	$44	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.83%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Navuridine AI Summary

Navuridine demonstrates broad-spectrum bioactivity, including significant antiviral effects against HIV and various murine leukemia viruses. Notably, it inhibits HIV-1 replication in peripheral blood mononuclear cells with an EC50 value ranging from 160.0 to 200.0 nM and has shown an effective dose (ED50) of 0.178 to 0.43 µM in MT-4 cells. It displays moderate cytotoxicity, with CD50 values of 39.0 to 244.0 µM, resulting in selectivity indices that underscore its specificity for HIV-infected cells. Additionally, it has an IC50 value of 2760.0 nM for 50% HIV replication inhibition and shows an anti-Rauscher-Murine leukemia virus (R-MuLv) activity with an IC50 of 138000.0 nM. The compound has been found to inhibit thymidine and deoxycytidine kinases in L1210 cells, suggesting a potential role in disrupting cellular nucleotide metabolism. Its pharmacokinetic profile includes high brain exposure relative to serum and moderate to fast plasma clearance, with a half-life between 0.84 and 4.34 hours. Lastly, it exhibits notable activity against JMJD2A-Tudor domain inhibition, DNA re-replication in colon adenocarcinoma cells, and synthetic lethality induction, indicating possible anticancer applications. Despite its promising antiviral and anticancer activities, Navuridine shows low antifungal and antibacterial activities, and negligible cytotoxicity in HEK293 cells and human red blood cells at higher concentrations..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Navuridine (AZdU) is an oral active inhibitor of HIV reverse transcriptase with a relatively short half-life.
Synonyms	CS-87, CS 87, AzUrd, AZdU, AZddU, 3'-Azido-2',3'-dideoxyuridine

Chemical Properties

Molecular Weight	253.22
Formula	C₉H₁₁N₅O₄
Cas No.	84472-85-5
Smiles	OC[C@H]1O[C@H](C[C@@H]1N=[N+]=[N-])n1ccc(=O)[nH]c1=O
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: Soluble

DMSO: 30 mg/mL (118.47 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.9 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.9491 mL	19.7457 mL	39.4914 mL	197.4568 mL
5 mM	0.7898 mL	3.9491 mL	7.8983 mL	39.4914 mL
10 mM	0.3949 mL	1.9746 mL	3.9491 mL	19.7457 mL
20 mM	0.1975 mL	0.9873 mL	1.9746 mL	9.8728 mL
50 mM	0.0790 mL	0.3949 mL	0.7898 mL	3.9491 mL
100 mM	0.0395 mL	0.1975 mL	0.3949 mL	1.9746 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc