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Search Results for " failure "

20

Compounds

Cat No. Product Name Synonyms Targets
T10515 Anti-Heart Failure Agent 1 Others
Anti-Heart Failure Agent 1 is an orally available compound suitable for the treatment of heart failure without inducing vomiting, nausea, and restlessness.
T2320 Indacaterol Adrenergic Receptor
Indacaterol (Onbrez; Arcapta) is a β2-Adrenergic Agonist. The mechanism of action of indacaterol is as an Adrenergic beta2-Agonist.
T5033 Olprinone Loprinone PDE
Olprinone (Loprinone)(Loprinone) is a selective phosphodiesterase 3 (PDE3) inhibitor.Olprinone has been reported to improve microcirculation and attenuate inflammation. Olprinone is often used to increase cardiac output ...
T9911 Tocilizumab Interleukin
Tocilizumab (anti-IL-6R) is a humanized monoclonal antibody that binds to the interleukin-6 receptor
T9022 AZD9977 AZD 9977 Glucocorticoid Receptor
AZD9977 is a novel, selective modulator of mineralocorticoid receptor .
T1265 Amrinone Inamrinone,Inocor,Wincoram TNF , PDE
Amrinone (Inocor) is a positive inotropic cardiotonic (cardiotonic agent) with vasodilator properties, phosphodiesterase 3 inhibitory activity.
T7686 Ramiprilat RAAS
Ramiprilat is an angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity.
T16873 SERCA2a activator 1 Calcium Channel
SERCA2a activator 1 is a sarco/endoplasmic reticulum Ca2+-dependent ATPase 2a activator. SERCA2a activator 1 decreases phospholamban inhibition and enhances the systolic and diastolic functions of the heart.
T8149 Dobutamine hydrochloride Dobutamine (hydrochloride) Adrenergic Receptor
Dobutamine hydrochloride (Dobutamine (hydrochloride)) is a catecholamine that acts as a β-adrenergic receptor agonist with potent positive inotropic effects.
T6086 Clopamide Brinaldix,Adurix,Aquex Sodium Channel
Clopamide (Brinaldix) is a piperidine and sulfamoylbenzamide-based diuretic with thiazide-like diuretic activity.
T39789 BMS-986235 BMS-986235,LAR-1219 Others
BMS-986235 (LAR-1219) is a selective and orally active agonist of formyl peptide receptor 2 (FPR2) with EC50s of 0.41 nM and 3.4 nM for hFPR2 and mFPR2, respectively. BMS-986235 can be used in studies about the preventio...
T19399 L-Ornithine L-aspartate Ornithine Aspartate Others
L-Ornithine L-aspartate (Ornithine Aspartate) lowers blood ammonia concentration and to eliminate symptoms of hepatic encephalopathy associated with liver cirrhosis.
T14989 CMPD101 ROCK , GRK , PKC
CMPD101 is a membrane-permeable small-molecule inhibitor of GRK2/3 (IC50: 18 nM and 5.4 nM). Which can be used for the study of heart failure. CMPD101 exhibits less selectively against GRK1, GRK5, ROCK-2 and PKCα with I...
T6716 Valsartan Diovan,Tareg,CGP 48933 RAAS
Valsartan (CGP 48933) is a tetrazole derivative and angiotensin II type 1 receptor blocker that is used to treat hypertension.
T1461 Candesartan CV 11974 RAAS
Candesartan (CV 11974) is an angiotensin II receptor blocker used widely in the therapy of hypertension and heart failure.
T4574 Sacubitril AHU 377,AHU377,AHU-377 Neprilysin
Sacubitril (AHU-377) is a potent NEP inhibitor with an IC50 of 5 nM. Sacubitril is a component of the heart failure medicine LCZ696.
T1410 Torsemide AC-4464,JDL-464,Torasemide Na-K-Cl cotransporter
Torsemide (AC-4464) is an anilinopyridine sulfonylurea belonging to the class of loop diuretics. Torsemide has a prolonged duration of action compared to other loop diuretics, is extensively protein bound in plasma and h...
T5329 Trandolapril Angiotensin-converting Enzyme (ACE)
Trandolapril is an orally administered angiotensin converting enzyme (ACE) inhibitor that is hydrolysed to the active diacid trandolaprilat.
T2718 Palmatine chloride Others , Indoleamine 2,3-Dioxygenase (IDO) , Aurora Kinase
Palmatine chloride an isoquinoline alkaloid, is an important medicinal herbal extract with diverse pharmacological and biological properties.
T7714 Temocapil Tyrosinase
Temocapril is an inhibitor of tyrosine kinase.
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TargetMol