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Immunology/Inflammation IL Receptor Tocilizumab

Tocilizumab

Catalog No. T9911   CAS 375823-41-9
Synonyms: Tocilizumab (anti-IL-6R), anti-IL-6R, MRA

Tocilizumab anti-IL-6R) is a humanized monoclonal antibody that binds to the interleukin-6 receptor

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
Tocilizumab, CAS 375823-41-9
Pack Size Availability Price/USD Quantity
5 mg In stock 558.00
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Purity 99.1%
Biological Description
Chemical Properties
Storage & Solubility Information
Description Tocilizumab anti-IL-6R) is a humanized monoclonal antibody that binds to the interleukin-6 receptor
Targets&IC50 IL-6R
Cell Research
Objective: To validate that IL-6 signaling is essential for TAM (tumor-associated macrophages)-enhanced CSC (cancer stem cells) function Concentrations: 5 μg/ml Incubation Time: 72 h Method: For co-culture experiments, 12-well Transwell chambers were used with 2×105 HepG2 or Hep3B cells seeded in the lower chamber one day before co-culture and either 5×105 or 1×106 TAMs added in the upper chamber. Tocilizumab or human IgG antibody were added in indicated experiments to selected wells. After 24 to 72 hours, HCC cells and CD14+ TAM cells were collected separately for analysis. Cells:HepG2 cell lines, TAMs isolated from HCCs (hepatocellular carcinoma)
Animal Research
Objective: Therapeutic assessment of Tocilizumab-Alendronate Conjugate in collagen-induced arthritis (CIA) mice model Formulation: PBS Dosages: 0.8 mg/kg Administration: Locally injected on the arthritic ankle joints Animal Models:DBA/1j mice were injected with CII which emulsified in CFA or IFA
Synonyms Tocilizumab (anti-IL-6R) , anti-IL-6R , MRA
Purity 99.1%
Molecular Weight 148000
CAS No. 375823-41-9

Storage

Store the unopened solution at -20℃, and store it at 4℃ after melting to avoid repeated freeze-thaw

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Garbers C, et al. Inhibition of classic signaling is a novel function of soluble glycoprotein 130 (sgp130), which is controlled by the ratio of interleukin 6 and soluble interleukin 6 receptor. J Biol Chem. 2011 Dec 16;286(50):42959-70 2. Kim NH, et al. Anti-proliferative action of IL-6R-targeted antibody tocilizumab for non-small cell lung cancer cells. Oncol Lett. 2015 May;9(5):2283-2288. 3. Shinriki S, et al. Humanized anti-interleukin-6 receptor antibody suppresses tumor angiogenesis and in vivo growth of human oral squamous cell carcinoma. Clin Cancer Res. 2009 Sep 1;15(17):5426-34.

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