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Search Results for " differentiation "

20

Compounds

Cat No. Product Name Synonyms Targets
T13829 Oiligodendrocyte differentiation promoter 1 Others
Oiligodendrocyte differentiation promoter 1 is a promoter of oiligodendrocyte differentiation .
T3816 Velutin NF-κB , HIF/HIF Prolyl-Hydroxylase
Velutin shows the strongest inhibitory effect in NF-κB activation and exhibits the greatest effects in blocking the degradation of inhibitor of NF-κB as well as in inhibiting mitogen-activated protein kinase p38 and JNK ...
TN5888 Toddaculin Others
Toddaculine may be beneficial for the prevention and treatment of osteoporosis, it can not only inhibit the differentiation of osteoclasts via activation of the NF-κB, ERK 1/2, and p38 MAPK signaling pathways, but can in...
TN1040 Skullcapflavone II COX , Antibacterial , TGF-beta/Smad
Skullcapflavone II is a flavonoid derived from Scutellaria baicalensis, a widely used herbal medicine in anti-inflammatory and anticancer therapy. Skullcapflavone II may have therapeutic potential for the treatment of al...
T5751 Tigogenin Others
Tigogenin is one of steroidal sapogenins which is widely used for synthesizing steroid drugs. It might have protective effect on bone and be helpful in preventing the development of osteoporosis.
T7693 Thiorphan Neprilysin
Thiorphan is an neprilysin inhibitor (NEP; IC50 : 0.007 μM).
TN1124 Neoeriocitrin AChE
Neoeriocitrin is a natural product isolated from Drynaria Rhizome, shows activity on proliferation and osteogenic differentiation in MC3T3-E1. Neoeriocitrin is a potent acetylcholinesterase (AChE) inhibitor.
T2S0712 Sinigrin Allylglucosinolate,2-Propenylglucosinolate Others
Sinigrin (2-Propenylglucosinolate), a glucosinolate, is used as a systrate to identify, differentiate and characterize myrosinase(s)/thioglucoside glucohydrolase(s)/thioglucosidase(s). Sinigrin is used as a reference mat...
T8839 ICCB280 Apoptosis , Others
ICCB280 was capable of inducing differentiation and apoptosis of ATRA-resistant patient blasts strongly signify that the activity of this compound can overcome resistance to other current therapies for AML with an unfavo...
T39508 KY-02327 Others
KY-02327, a metabolically stabilized analog of KY-02061, serves as a potent inhibitor of the Dishevelled (Dvl)-CXXC5 interaction. This compound activates the Wnt/β-catenin pathway, thereby promoting osteoblast differenti...
T1748 Kartogenin KGN TGF-beta/Smad
Kartogenin (KGN) is an activator of the smad4/smad5 pathway, and promotes the selective differentiation of multipotent mesenchymal stem cells into chondrocytes.
T2340 AC1NS4RE Tyrosinase
It is a tyrosine kinase inhibitor.
T2052 KY02111 Wnt/beta-catenin
KY02111 facilitates differentiation of hPSCs to cardiomyocytes by inhibiting Wnt signaling, maybe affect downstream of GSK3β and APC.
T9243 PFI-90 Histone Demethylase , Others
PFI-90, a selective histone demethylase (KDM3B) inhibitor, targets PAX3-FOXO1 action and demonstrates potential antitumor activity. It induces apoptosis and myogenic differentiation, leading to increased cell death.
TP1328 TB500 Others
TB-500 is a synthesised peptide, essentially a short-chain version of the naturally occurring Thymosin Beta-4.
T9210 CD73-IN-4 CD73
CD73-IN-4 is a potent and selective methylenephosphonic acid CD73 inhibitor
T1176 Racecadotril Acetorphan Neprilysin , Proteasome
Racecadotril (Acetorphan) has been investigated for the basic science and treatment of Diarrhea, Acute Diarrhea, and Acute Gastroenteritis.
T13336 VTP50469 Apoptosis , Epigenetic Reader Domain , Histone Methyltransferase
VTP50469 is a highly selective and orally active inhibitor of Menin-MLL interaction( Ki: 104 pM) and has potently anti-leukemia activity.
TN1651 Furanodiene Apoptosis , PARP , Reactive Oxygen Species , Caspase , CDK , P-gp
Furanodiene has anti-inflammatory and antioxidant activities, it is active against gram-positive bacteria and Candida albicans.
T1938 FLT3-IN-2 FLT
FLT3-IN-2 is an FLT3 inhibitor (IC50<1 μM).
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