deficient — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T4886	Dihydrouracil	5,6-Dihydrouracil	Endogenous Metabolite
	5,6-Dihydrouracil (5,6-Dihydrouracil) is an intermediate breakdown product of uracil.		Endogenous Metabolite
T12079	ML604440		Proteasome
	ML604440 is a cell permeable proteasome β1i (LMP2) subunit inhibitor.		Proteasome
T9756	AZD-9574		PARP
	AZD-9574 is a selective inhibitor of PARP1 at the sites of SSBs. AZD-9574 exhibits anti-cancer activities and can be used in studies about HRD+ breast cancer and advanced solid malignancies.		PARP
T26396	6-Hydroxy-DOPA	6-Hydroxy-DL-DOPA	DNA/RNA Synthesis
	6-Hydroxy-DOPA is an allosteric inhibitor of RAD52, it inhibits proliferation of BRCA-deficient cancer cells in vitro and also inhibits APE1.		DNA/RNA Synthesis
T20689	Temocaprilat	RNH-5139,RS-5139,RNH 5139,RNH5139,RS5139,RS 5139	Angiotensin-converting Enzyme (ACE)
	Temocaprilat (RS5139) is an Angiotensin-converting Enzyme (ACE) inhibitor. Temocaprilat is effectively excreted in bile via cMOAT that is deficient in EHBR and that many of other ACE inhibitors have low affinity for cMOA...		Angiotensin-converting Enzyme (ACE)
T69638	VT-105	VT 105	Others
	VT-105 is a potent and selective TEAD autopalmitoylation inhibitor that inhibits proliferation and tumour growth in NF2-deficient mesotheliomas.		Others
T13482	2'-O-Methyladenosine		Endogenous Metabolite
	2'-O-Methyladenosine, a methylated adenine residue is found in the urine of normals and adenosine deaminase deficient patients. It shows unique hypotensive activities.		Endogenous Metabolite
T76735	Mupadolimab	CPI-006	CD73
	Mupadolimab (CPI-006) is a humanized FC-γR binding deficient IgG1 anti-CD73 antibody with potential anticancer activity and activation of CD73POS B cells.		CD73
T11593	I-OMe-Tyrphostin AG 538	I-OMe-AG 538	IGF-1R , PI3K
	I-OMe-Tyrphostin AG 538 is a specific IGF-1R inhibitor and ATP-competitive inhibitor of PI5P4Kα (IC50: 1 µM).I-OMe-Tyrphostin AG 538 inhibits IGF-1R-mediated signaling and exhibits preferential cytotoxicity to nutrient-d...		IGF-1R , PI3K
T26326	VU0285655-1	VU-0285655,VU0285655,BML 280,VU 0285655,BML280,BML-280	TNF , Phospholipase , Interleukin
	VU0285655-1(BML-280) is a potent and selective phospholipase D2 (PLD2) inhibitor that inhibits the proliferation of PLD2-deficient cells.VU0285655-1 has an inhibitory effect on high glucose-induced caspase-3 cleavage and...		TNF , Phospholipase , Interleukin
T37558	Necrostatin-5	Nec-5	RIP kinase , Necroptosis
	Necrostatin-5 (Nec-5) is a selective inhibitor of RIP1 kinase and a cell necrosis inhibitor that prevents the death of Fadd-deficient Jurkat cells treated with TNF-α with an EC50 value of 240 nM.		RIP kinase , Necroptosis
T3424	Ezutromid	BMN 195,VOX-C1100,SMT C1100	Others
	Ezutromid (BMN 195) is a translation modulator of Small utrophin (EC50: 0.4 uM). Ezutromid is an orally bioavailable small molecule that transcriptionally upregulates the utrophin gene, increasing both utrophin mRNA and ...		Others
T36491	POMHEX		Glucokinase
	Pomhex, a cell-permeable potent enolase inhibitor with anticancer activity, is used in the study of cancer lethality.Pomhex, a racemic mixture, is a potent and selective ENO2 inhibitor.Pomhex is inhibitory to the glycoly...		Glucokinase
T9088	Topovale	ARC111,ARC 111,ARC-111,Topoval	Topoisomerase
	Topovale (ARC111) is a potent inhibitor of topoisomerase I. Topovale inhibits hypoxia-mediated accumulation of hypoxia-inducible factor-1alpha. Topovale exhibited low nM cytotoxicity against a panel of cancer cells. Topo...		Topoisomerase
T10936	D-I03	DI03	DNA/RNA Synthesis
	D-I03 is a selective RAD52 inhibitor with a Kd of 25.8 µM. D-I03 specifically inhibits RAD52-dependent single-chain annealing (SSA) and D-loop formation, with IC50 of 5 µM and 8 µM, respectively. D-I03 inhibited the grow...		DNA/RNA Synthesis
T63228	Simmiparib	SMOCL-9112	Apoptosis , PARP
	Simmiparib (SMOCL-9112) is a novel and potent PARP1 and PARP2 inhibitor, a derivative of Olaparib.Simmiparib induces DNA double-strand breaks (DSBs) and cell cycle arrest in homologous recombination repair (HR)-deficient...		Apoptosis , PARP
T9543	Syk Inhibitor II hydrochloride		Others
	The impact of spleen tyrosine kinase (Syk) signaling might be prominent in lupus because (i) Syk is a shared downstream signaling molecule among circulating immune complex, LPS, and (1→3)-β-D-glucan (BG), and (ii) all of...		Others
T4719	1,4-D-Gulonolactone	D-Gulonic acid γ-lactone	Others , Endogenous Metabolite
	1,4-D-Gulonolactone (D-Gulonic acid γ-lactone) (also known as reduced ascorbic acid, RAA) is the substrate of the enzyme L-gulono-1,4-lactone oxidoreductase (EC 1.1.3.8), which catalyzes the last step of the biosynthesis...		Others , Endogenous Metabolite
T26168	Rufigallol	AI3 00865,AI3-00865,AI300865
	Rufigallol (AI3-00865) is an electron-deficient disk-shaped molecule with six hydroxyl groups and is a good unit for inducing the formation of DLC from non-planar AIE molecules, an anthraquinone derivative.Rufigallol ind...
T35449	α-(difluoromethyl)-DL-Arginine	DFMA,RMI 71897,α-(difluoromethyl)-DL-Arginine	Others
	α-(difluoromethyl)-DL-Arginine (RMI 71897) is an enzyma-activated, irreversible inhibitor of arginine decarboxylase for E. coli (Ki = 800 μM), Pseudomonas aeruginosa, and Klebsiella pneumoniae. At 0.01 mM, it has been sh...		Others