Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Topovale (ARC111) is a potent inhibitor of topoisomerase I. Topovale inhibits hypoxia-mediated accumulation of hypoxia-inducible factor-1alpha. Topovale exhibited low nM cytotoxicity against a panel of cancer cells. Topovale cytotoxicity as well as Topovale-induced apoptosis was reduced < 100-fold in CPT-resistant topoisomerase I (TOP1)-deficient P388/CPT45 cells as compared with P388 cells.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 88.00 | |
5 mg | In stock | $ 179.00 | |
10 mg | In stock | $ 255.00 | |
25 mg | In stock | $ 460.00 | |
50 mg | In stock | $ 676.00 | |
100 mg | In stock | $ 962.00 |
Description | Topovale (ARC111) is a potent inhibitor of topoisomerase I. Topovale inhibits hypoxia-mediated accumulation of hypoxia-inducible factor-1alpha. Topovale exhibited low nM cytotoxicity against a panel of cancer cells. Topovale cytotoxicity as well as Topovale-induced apoptosis was reduced > 100-fold in CPT-resistant topoisomerase I (TOP1)-deficient P388/CPT45 cells as compared with P388 cells. |
Synonyms | ARC111, ARC 111, ARC-111, Topoval |
Molecular Weight | 421.45 |
Formula | C23H23N3O5 |
CAS No. | 500214-53-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: Insoluble
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Topovale 500214-53-9 DNA Damage/DNA Repair Topoisomerase ARC111 ARC 111 ARC-111 Topoval inhibitor inhibit