store at low temperature,keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
6-Hydroxy-DOPA is an allosteric inhibitor of RAD52, it inhibits proliferation of BRCA-deficient cancer cells in vitro and also inhibits APE1.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 48.00 | |
2 mg | In stock | $ 71.00 | |
5 mg | In stock | $ 122.00 | |
10 mg | In stock | $ 197.00 | |
25 mg | In stock | $ 417.00 | |
50 mg | In stock | $ 619.00 | |
100 mg | In stock | $ 879.00 | |
500 mg | In stock | $ 1,790.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 116.00 |
Description | 6-Hydroxy-DOPA is an allosteric inhibitor of RAD52, it inhibits proliferation of BRCA-deficient cancer cells in vitro and also inhibits APE1. |
In vitro | We identify the small molecule 6-hydroxy-DL-dopa (6-OH-dopa) as a major allosteric inhibitor of the RAD52 ssDNA binding domain. For example, we find that multiple small molecules bind to and completely transform RAD52 undecamer rings into dimers, which abolishes the ssDNA binding channel observed in crystal structures. 6-OH-Dopa also disrupts RAD52 heptamer and undecamer ring superstructures, and suppresses RAD52 recruitment and recombination activity in cells with negligible effects on other double-strand break repair pathways. |
In vivo | Importantly, we show that 6-OH-dopa selectively inhibits the proliferation of BRCA-deficient cancer cells, including those obtained from leukemia patients. Taken together, these data demonstrate small-molecule disruption of RAD52 rings as a promising mechanism for precision medicine in BRCA-deficient cancers. |
Synonyms | 6-Hydroxy-DL-DOPA |
Molecular Weight | 213.19 |
Formula | C9H11NO5 |
CAS No. | 21373-30-8 |
store at low temperature,keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 2.13 mg/mL (10 mM)
You can also refer to dose conversion for different animals. More
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6-Hydroxy-DOPA 21373-30-8 Cell Cycle/Checkpoint DNA Damage/DNA Repair DNA/RNA Synthesis U20S effective ssDNA 6 Hydroxy DOPA 6HydroxyDOPA Inhibitor allosteric 6-Hydroxy-DL-DOPA inhibit selective HCC1937 cancer inhibitor