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α-(difluoromethyl)-DL-Arginine

Catalog No. T35449 CAS 69955-43-7

Synonyms: DFMA, RMI 71897, α-(difluoromethyl)-DL-Arginine

α-(difluoromethyl)-DL-Arginine (RMI 71897) is an enzyma-activated, irreversible inhibitor of arginine decarboxylase for E. coli (Ki = 800 μM), Pseudomonas aeruginosa, and Klebsiella pneumoniae. At 0.01 mM, it has been shown to prevent osmotic stress-induced increases in arginine decarboxylase activity and putrescine synthesis in oat leaf cells. When combined with a variety of polyamine analogues, α-(difluoromethyl)-DL-Arginine inhibited the growth of Trypanosoma Crui in mammalian host cells at a minimum concentration of 10 mM and prevented the growth of Trypanosoma Crui in T-cell receptor alpha-deficient mouse models.

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α-(difluoromethyl)-DL-Arginine Chemical Structure

α-(difluoromethyl)-DL-Arginine, CAS 69955-43-7

Pack Size	Availability	Price/USD
1 mg	In stock	$ 73.00
5 mg	In stock	$ 210.00
10 mg	In stock	$ 342.00
25 mg	In stock	$ 510.00
50 mg	In stock	$ 739.00
100 mg	In stock	$ 987.00
500 mg	In stock	$ 1,980.00

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Purity: 99.77%

Purity: 99.68%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	DFMA, RMI 71897, α-(difluoromethyl)-DL-Arginine
Molecular Weight	224.21
Formula	C7H14F2N4O2
CAS No.	69955-43-7

Storage

keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

PBS (pH 7.2): 5 mg/mL

PBS: 4.5 mg/mL (20.1 mM)

References and Literature

1. Gill, S.S., et al. Polyamines and abiotic stress tolerance in plants. Plant Signal. Behav. 5(1), 26-33 (2010). 2. A Kallio, et al. DL-α-(Difluoromethyl)arginine: A potent enzyme-activated irreversible inhibitor of bacterial decarboxylases. Biochemistry 20(11), 3163-3168 (1981). 3. Tiburcio, A.F, et al. Polyamine metabolism and osmotic stress. II. Improvement of oat protoplasts by an inhibitor of arginine decarboxylase. Plant Physiology 82, 375-378 (1986). 4. Flores, H.E, et alPolyamines and plant stress: Activation of putrescine biosynthesis by osmotic shock. Science 217(4566), 1259-1261 (1982). 5. Kierszenbaum, F, et al. Arginine decarboxylase inhibitors reduce the capacity of Trypanosoma cruzi to infect and multiply in mammalian host cells. Proceedings of the National Academy of Sciences of the United States of America 84(12), 4278-4282 (1987). 6. Nigel Yarlett, et al. Activities of DL-α-difluoromethylarginine and polyamine analogues against Cryptosporidium parvum infection in a T-cell receptor α-deficient mouse model. Antimicrobial Agents and Chemotherapy 51(4), 1234-1239 (2007).

Related compound libraries

This product is contained In the following compound libraries：

Anti-Parasitic Compound Library Inhibitor Library Bioactive Compounds Library Max Bioactive Compound Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

α-(difluoromethyl)-DL-Arginine 69955-43-7 Others a-(difluoromethyl)-DL-Arginine DFMA RMI-71897 RMI71897 RMI 71897 alpha-(difluoromethyl)-DL-Arginine inhibitor inhibit

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