cytotoxic — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
TN7043	Neolancerin		Others
	Neolancerin is a natural product isolated from adventitious roots of St. John’s wort (Hypericum perforatum L.).		Others
T40588	Acifluorfen		Others
	Acifluorfen, a protoporphyrinogen oxidase (PROTOX) inhibitor herbicide, promotes the accumulation of protoporphyrin IX (PPIX) and induces tumors in rodent livers. It causes significant photooxidative damage to pigments a...		Others
T32291	Jineol	NSC694081,3,8-Quinolinediol,NSC 694081,NSC-694081	Others
	Jineol (NSC-694081) is a quinoline alkaloid from Scolopendra subspinipes. Jineol shows cytotoxic activity against the growth of human tumor cell lines in vitro.		Others
T38272	Thiacloprid		AChR , Parasite
	Thiacloprid is a neonicotinoid insecticide that acts as a selective agonist at insect nicotinic acetylcholine receptors (nAChRs) with IC50values of 2.7 and 860 nM forDrosophilanAChRs and M10 mouse fibroblast cells expres...		AChR , Parasite
TN1722	Hamamelitannin		Antifection
	Hamamelitannin has cytotoxic, and antibiofilm activities. It increases the susceptibility of S. aureus to antibiotic treatment in in vivo Caenorhabditis elegans and mouse mammary gland infection models. It also has a hig...		Antifection
TN2182	Sarracenin		Others
	Sarracenin is a natural product. Sarracenin shows cytotoxic activities against tumor cells.		Others
TN6512	Tectol		Transferase , Parasite
	Tectol has anti-plasmodial activity, it as a moderately active growth inhibitor with an IC50 3.44±0.20μM. It exhibited significant activity against human leukemia cell lines HL60 and CEM. Tectol may cause itchy dermatiti...		Transferase , Parasite
T12189	NBDHEX		Apoptosis , Glutathione Peroxidase , Autophagy
	NBDHEX is a potent inhibitor of glutathione S-transferase P1-1 (GSTP1-1) .		Apoptosis , Glutathione Peroxidase , Autophagy
T21165	Pellitorine	AI3-19560,Pellitorin	TRP/TRPV Channel
	Pellitorine (Pellitorin) is an extract of Tetradium daniellii, and acts as a TRPV1 antagonist.		TRP/TRPV Channel
T21859	ARM1		Aminopeptidase , Epoxide Hydrolase
	ARM1 is a potent inhibitor of aminopeptidase and epoxide hydrolase. The IC50 values are 7.61 µM for aminopeptidase and 12.4 µM for epoxide hydrolase.		Aminopeptidase , Epoxide Hydrolase
TN6720	Acetylalkannin	Acetyl alkannin,Alkannin acetate	Antibacterial
	Acetylalkannin (Alkannin acetate), an isohexenylnaphthazarin pigment extracted from Arnebia euchroma, exhibits antimicrobial and cytotoxic properties.		Antibacterial
T6683	STF-62247	STF 62247	Estrogen/progestogen Receptor , Autophagy
	STF-62247 is TGN inhibitor with IC50 of 0.625 μM and 16 μM in RCC4 and RCC4/VHL cells, respectively.		Estrogen/progestogen Receptor , Autophagy
T5808	(-)-Oxypeucedanin hydrate	OXYPEUCEDANIN HYDRATE	Others
	(-)-Oxypeucedanin hydrate is a furanocoumarin. It has a role as a metabolite.		Others
T13780	MS1943		Apoptosis , Histone Methyltransferase
	MS1943 is a orally bioavailable EZH2 selective degrader(IC50 of 120 nM).		Apoptosis , Histone Methyltransferase
T9014	SKI-178		Apoptosis , S1P Receptor
	SKI-178 is a sphingosine kinase 1 (SphK1) inhibitor with IC50 of 0.1-1.8 μM. It induces prolonged mitosis followed by apoptotic cell death through the intrinsic apoptotic cascade. The sustained activation of CDK1 during ...		Apoptosis , S1P Receptor
T13741	Isoviolanthin		Others
	Isoviolanthin reduces the migratory and invasive capacities of TGF-β1-treated HCC cells without cytotoxic effects on normal live cells and has potential as a therapeutic agent for the treatment of advanced-stage metastat...		Others
T15588	Iobenguane sulfate	MIBG sulfate	Others
	Iobenguane sulfate (MIBG sulfate) is a high-affinity substrate for cholera toxin that interferes with cellular mono(ADP-ribosylation). Radioiodinated Iobenguane sulfate is clinically used as a tumor-targeted radiopharmac...		Others
T12134	MYCMI-6	NSC354961	Apoptosis , c-Myc
	MYCMI-6 (NSC-354961) is a potent and selective inhibitor of endogenous MYC:MAX protein interactions，reduces proliferation and induces massive apoptosis in tumor tissue from a MYC-driven xenograft tumor model without seve...		Apoptosis , c-Myc
T38562	AKN-028		FLT
	AKN-028 is an orally active and potent FLT3 tyrosine kinase inhibitor ( IC 50 = 6 nM). AKN-028 causes dose-dependent inhibition of FLT3 autophosphorylation.		FLT
T21854	Proteasome inhibitor IX	PS-IX,AM114	Proteasome
	Proteasome inhibitor IX (PS-IX) is an inhibitor of chymotrypsin-like activity of the 20S proteasome (IC50 ~1 μM). Proteasome inhibitor IX shows potent anticancer activity. Proteasome inhibitor IX exhibits HCT116 p53+/+ c...		Proteasome