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Proteasome inhibitor IX

🥰Excellent
Catalog No. T21854Cas No. 856849-35-9
Alias PS-IX, AM114

Proteasome inhibitor IX (PS-IX) is an inhibitor of chymotrypsin-like activity of the 20S proteasome (IC50 ~1 μM). Proteasome inhibitor IX shows potent anticancer activity. Proteasome inhibitor IX exhibits HCT116 p53+/+ cells growth inhibitory activity(IC50 = 1.49 μM).

Proteasome inhibitor IX

Proteasome inhibitor IX

🥰Excellent
Purity: 99.77%
Catalog No. T21854Alias PS-IX, AM114Cas No. 856849-35-9
Proteasome inhibitor IX (PS-IX) is an inhibitor of chymotrypsin-like activity of the 20S proteasome (IC50 ~1 μM). Proteasome inhibitor IX shows potent anticancer activity. Proteasome inhibitor IX exhibits HCT116 p53+/+ cells growth inhibitory activity(IC50 = 1.49 μM).
Pack SizePriceAvailabilityQuantity
10 mg$34In Stock
25 mg$68In Stock
50 mg$120In Stock
100 mg$201In Stock
500 mg$482In Stock
1 mL x 10 mM (in DMSO)$32In Stock
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This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Purity:99.77%
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COA HNMR LCMS

Product Introduction

Bioactivity
Description
Proteasome inhibitor IX (PS-IX) is an inhibitor of chymotrypsin-like activity of the 20S proteasome (IC50 ~1 μM). Proteasome inhibitor IX shows potent anticancer activity. Proteasome inhibitor IX exhibits HCT116 p53+/+ cells growth inhibitory activity(IC50 = 1.49 μM).
Targets&IC50
20S proteasome:1 μM
In vitro
AM114 exhibits potent activity against p53+/+ cells in colony formation assay, with an IC50 value of 0.6 μM[2]. AM114 treatment inhibits the chymotrypsin-like activity of the 20S proteasome in vitro, leading to a significant accumulation of ubiquitinated p53 and other cellular proteins in whole cells[2]. In HCT116 p53+/+ cells, AM114(0.1-10 μM) treatment causes a loss of cell survival in the p53+/+ and p53-/- cells by approximately 70 and 20%, respectively at a concentration of 1 μM[2].
SynonymsPS-IX, AM114
Chemical Properties
Molecular Weight377.01
FormulaC20H21B2NO5
Cas No.856849-35-9
SmilesCN1C\C(=C\c2ccc(cc2)B(O)O)C(=O)\C(C1)=C/c1ccc(cc1)B(O)O
Relative Density.1.32 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 40 mg/mL (106.1 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.6524 mL13.2622 mL26.5245 mL132.6225 mL
5 mM0.5305 mL2.6524 mL5.3049 mL26.5245 mL
10 mM0.2652 mL1.3262 mL2.6524 mL13.2622 mL
20 mM0.1326 mL0.6631 mL1.3262 mL6.6311 mL
50 mM0.0530 mL0.2652 mL0.5305 mL2.6524 mL
100 mM0.0265 mL0.1326 mL0.2652 mL1.3262 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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Keywords

ubiquitinatedProteasome inhibitor IXProteasomep53InhibitorinhibitEGCGcytotoxicchymotrypsin-likeChalconeboronicAnticancerAM-114AM 114acid20S proteasome20S
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