Powder: -20°C for 3 years
In solvent: -80°C for 2 years
SKI-178 is a sphingosine kinase 1 (SphK1) inhibitor with IC50 of 0.1-1.8 μM. It induces prolonged mitosis followed by apoptotic cell death through the intrinsic apoptotic cascade. The sustained activation of <a href="/target/CDK" style="display: inline; color: #c13a36">CDK</a>1 during prolonged mitosis, mediated by SKI-178 leads to the simultaneous phosphorylation of the prosurvival <a href="/target/BCL" style="display: inline; color: #c13a36">BCL</a>-2 family members, <a href="/target/BCL" style="display: inline; color: #c13a36">BCL</a>-2 and <a href="/target/BCL" style="display: inline; color: #c13a36">BCL</a>-xl, as well as the phosphorylation and subsequent degradation of Mcl-1.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | In stock | $ 48.00 | |
5 mg | In stock | $ 70.00 | |
10 mg | In stock | $ 121.00 | |
25 mg | In stock | $ 233.00 | |
50 mg | In stock | $ 380.00 | |
100 mg | In stock | $ 567.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 80.00 |
Description | SKI-178 is a sphingosine kinase 1 (SphK1) inhibitor with IC50 of 0.1-1.8 μM. It induces prolonged mitosis followed by apoptotic cell death through the intrinsic apoptotic cascade. The sustained activation of CDK1 during prolonged mitosis, mediated by SKI-178 leads to the simultaneous phosphorylation of the prosurvival Bcl-2 family members, Bcl-2 and Bcl-xl, as well as the phosphorylation and subsequent degradation of Mcl-1. |
Targets&IC50 | SphK1:0.1-1.8 μM |
In vitro | SKI-178 is a multi-targeted agent that functions both as an inhibitor of the SphKs as well as a disruptor of the microtubule network.?SKI-178 induced apoptosis arises from a synergistic interaction of these two activities.?SKI-178 is safe and effective in mouse models of AML, supporting its further development as a multi-targeted anti-cancer therapeutic agent[1]. |
Molecular Weight | 394.431 |
Formula | C21H22N4O4 |
CAS No. | 1259484-97-3 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: 50 mg/mL (126.77 mM), Need ultrasonic
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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SKI-178 1259484-97-3 Apoptosis GPCR/G Protein S1P Receptor resistant SphK cytotoxic myeloid Inhibitor leukemia multi-drug inhibit cancer Sphingosine kinase SKI178 drug sensitive cell SKI 178 inhibitor