cytokine — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T5033	Olprinone	Loprinone	PDE
	Olprinone (Loprinone)(Loprinone) is a selective phosphodiesterase 3 (PDE3) inhibitor.Olprinone has been reported to improve microcirculation and attenuate inflammation. Olprinone is often used to increase cardiac output ...		PDE
T4S0878	Prunetin	Prunusetin	ERK , Dehydrogenase , NF-κB
	1. Prunetin (Prunusetin) significantly reduces serum levels of inflammatory cytokines and mortality in mice challenged with lipopolysaccharide. 2. Prunetin mediates anti-obesity/adipogenesis effects by suppressing obesit...		ERK , Dehydrogenase , NF-κB
T16111	ML604086		CCR
	ML604086 suppresses CCL1 mediated chemotaxis and enhances intracellular Ca2 concentrations. ML604086 is a selective inhibitor of CCR8. It also inhibiting CCL1 binding to CCR8 on circulating T-cells.		CCR
T1421	Aceclofenac	Preservex,Airtal	COX
	Aceclofenac (Preservex) is a non-steroidal anti-inflammatory drug (NSAID) with marked anti-inflammatory and analgesic properties.		COX
T15102	Dexamethasone palmitate	DXP	Glucocorticoid Receptor
	Dexamethasone palmitate (DXP), a lipophilic prodrug of Dexamethasone, shows a 47-fold lower affinity for the glucocorticoid receptor than Dexamethasone. Dexamethasone palmitate is a glucocorticoid receptor agonist and an...		Glucocorticoid Receptor
T13951	UCB-9260		TNF
	UCB-9260 inhibits TNF signaling by stabilizing an asymmetric form of the trimer.		TNF
T7860	SM-324405	SM 324405	TLR
	SM-324405 is an agonist of TLR7.		TLR
T15784	LP99		Epigenetic Reader Domain
	LP99 is an epigenetic probe. LP99 disrupts the binding of BRD7 and BRD9 to chromatin in cells. LP99 is an effective and selective inhibitor of the BRD7 and BRD9 bromodomains (Kd: 99 nM against BRD9).		Epigenetic Reader Domain
T8716	Physalin F		Apoptosis
	Physalin F is a natural blocker of CaV2.3 (R-type) and CaV2.2 (N-type) voltage-gated calcium channels.It is a secosteroid with potent anti-inflammatory and immunomodulatory activities. Physalin F induces apoptosis of PBM...		Apoptosis
T20089	ATP	Atipi,ATP disodium salt hydrate,Triphosphoric acid adenosine ester,Ara-ATP,Triphosphaden,Adenosine triphosphate;Ara-ATP,Adenosine triphosphate	Endogenous Metabolite
	ATP (Adenosine triphosphate) provides cellular energy, participates in overall energy balance, and maintains intracellular homeostasis. ATP can act as an extracellular signaling molecule through interactions with specifi...		Endogenous Metabolite
T0498	Salsalate	Disalicylic acid,Salicylsalicylic acid,Sasapyrine,NSC-49171	Reactive Oxygen Species , COX
	Salsalate (Sasapyrine) is an orally available salicylate and non-steroidal anti-inflammatory drug (NSAID), with anti-inflammatory, analgesic and antipyretic activities.		Reactive Oxygen Species , COX
T1902	BAY 11-7082	BAY 11-7821	Apoptosis , Others , IκB/IKK , DUB , Autophagy
	BAY 11-7082 (BAY 11-7821) is an NF-κB inhibitor that inhibits TNFα-induced IκBα phosphorylation (IC50=10 μM). BAY 11-7082 is also an inhibitor of the ubiquitin-specific proteases USP7 and USP21 (IC50=0.19/0.96 μM).		Apoptosis , Others , IκB/IKK , DUB , Autophagy
T27695	JTE-607	JTE-607 dihydrochloride,JTE-607 HCl	Cysteine Protease
	JTE-607 is a cytokine production inhibitor. JTE-607 induces apoptosis accompanied by an increase in p21waf1/cip1 in acute myelogenous leukemia cells.		Cysteine Protease
T2812	ATP disodium salt hydrate	ATP disodium,ATP disodium salt,Adenosine disodium triphosphate	Others , Endogenous Metabolite
	ATP disodium salt hydrate (Adenosine disodium triphosphate) is a nucleoside triphosphate used in cells as a coenzyme often called the "molecular unit of currency" of intracellular energy transfer.		Others , Endogenous Metabolite
T2036	6-OAU	GTPL5846	GPR
	6-OAU (GTPL5846)(GTPL5846; 6-n-octylaminouracil) is a surrogate agonist of GPR84; activates human GPR84 in the presence of Gqi5 chimera in HEK293 cells with an EC50 of 105 nM in the PI assay.		GPR
T4602	Hydrocortisone hemisuccinate	Hydrocortisone 21-he,hydrocortisone 21-hemisuccinate*free acid,Hydrocortisone 21-hemisuccinate	Glucocorticoid Receptor , Others , Interleukin
	Hydrocortisone hemisuccinate (hydrocortisone 21-hemisuccinate*free acid) is a corticosteroid used as an analytical and chromatography reagent.		Glucocorticoid Receptor , Others , Interleukin
T1352	ATP disodium salt	Adenosine 5'-triphosphate disodium salt,ATP,ATP disodium,Adetide,Adenosine-Triphosphate,Disodium adenosine triphosphate	P2X Receptor , Endogenous Metabolite
	ATP disodium salt (Adenosine-Triphosphate) is a P2 purinoceptor agonist.		P2X Receptor , Endogenous Metabolite
TN1818	Kaempferol 3-O-β-D-glucuronide	Kaempferol-3-O-glucuronide,Kaempferol-3-beta-O-glucuronide,Kaempferol-3-glucuronide	IL Receptor
	Kaempferol 3-O-β-D-glucuronide (Kaempferol-3-beta-O-glucuronide)e has antioxidant activity. Flavonoid glucuronides can be deconjugated by microsomal α²-glucuronidase from various human cells.		IL Receptor
T6009	TAPI1	TAPI 1,TAPI,TAPI-1	MMP
	TAPI1 (TAPI) , an ADAM17/TACE inhibitor, inhibits shedding of cytokine receptors.		MMP
T25702	Levovirin	ICN 17261,L-Ribavirin,ICN-17261,ICN17261
	Levovirin is a monocyclic L-nucleosides with type 1 cytokine-inducing activity. Levovirin is the L-enantiomer of Ribavirin. Levovirin has similar immunomodulatory activity but does not have direct antiviral activity or h...