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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T23101 | O-3M3FBS | Others | |
Inactive analog of m-3M3FBS (PLC activator) | |||
T8581 | Flecainide hydrochloride | Others | |
Flecainide is a medication used to prevent and treat abnormally fast heart rates. This includes ventricular and supraventricular tachycardias. | |||
T4573 | Cyclothiazide | GluR | |
Cyclothiazide is a benzothiadiazide that acts as a potentiator of AMPA receptorsthat potently inhibits AMPA receptor desensitization, positively modulating its response to glutamic acid (EC50 = 3.8 M). | |||
T1186 | Ifenprodil Tartrate | Potassium Channel , NMDAR , iGluR | |
Ifenprodil is a selective NMDA receptor (glutamate) antagonist. | |||
T16348 | NS5806 | NS-5806 | Potassium Channel |
NS5806 is an effective potassium current activator. NS5806 slows KV4.3 and KV4.2 current decay in channel complexes containing KChIP2. NS5806 enhances KV4.3/KChIP2 peak current amplitudes (EC50: 5.3 μM). | |||
T23280 | Ruthenium Red | Ammoniated ruthenium oxychloride | Calcium Channel |
Ruthenium Red (Ammoniated ruthenium oxychloride) is a polycationic dye widely used for electron microscopy (EM) of cells, tissues and vegetative bacteria. Ruthenium red strongly reacts with phospholipids and fatty acids ... | |||
T16347 | NS3623 | Potassium Channel | |
NS3623 is an activator of human ether-a-go-go-related gene potassium channels. NS3623 has a dual mode of action, being an inhibitor of hERG1 channels. NS3623 activates the IKr and Ito currents and has an antiarrhythmic e... | |||
T15286 | Flindokalner | BMS-204352 | Potassium Channel |
Flindokalner (BMS-204352) is a potassium channel modulator and a positive modulator of all neuronal Kv7 channel subtypes expressed in HEK293 cells. Flindokalner is a large conductance calcium-activated K channel (BKca) p... | |||
T1434 | Clarithromycin | A-56268 | P450 , ribosome , MRP , Antibacterial , Antibiotic , Autophagy |
Clarithromycin (A-56268) is a Macrolide Antimicrobial. The mechanism of action of clarithromycin is as a Cytochrome P450 3A4 Inhibitor, and Cytochrome P450 3A Inhibitor, and P-Glycoprotein Inhibitor. The chemical classif... | |||
T2451 | GlyH-101 | GlyH 101 | CFTR , Autophagy |
GlyH-101 is a cell-permeable glycinyl hydrazone compound that blocks CFTR with Ki of 1.4 uM. | |||
T7775 | A2764 dihydrochloride | Potassium Channel | |
A2764 dihydrochloride is a highly selective inhibitor of TRESK. | |||
T4550 | Ajmaline | Cardiorythmine,Raugalline,Tachmalin,(+)-Ajmaline | Sodium Channel |
Ajmaline (Cardiorythmine) is a class Ia anti-arrhythmic compound that is widely used for the diagnosis of Brugada syndrome and the acute treatment of atrial or ventricular tachycardia. Ajmaline inhibits cardiac Kv1.5 and... | |||
T6541 | Ibutilide Fumarate | Corvert Fumarate,U70226E | Calcium Channel , Sodium Channel |
Ibutilide Fumarate (U70226E) is the fumarate salt form of ibutilide, a class III antiarrhythmic agent. Ibutilide exerts its effect by activating a slow, inward, predominately sodium current rather than by blocking outwar... | |||
T3574 | Sematilide hydrochloride | CK-1752A,CK-1752,Sematilide HCl | Potassium Channel |
Sematilide hydrochloride (CK-1752) is a class III antiarrhythmic. It is a selectively delayed rectifier K+ current (IKr) channel blocker. It inhibits rapidly activating Ik in guinea pig atrial myocytes, resulting in the ... | |||
T15758 | Linopirdine | DuP 996 | Potassium Channel , TRP/TRPV Channel |
Linopirdine (DuP 996) is a TRPV1 agonist. Linopirdine is an orally active and selective M-type K+ current (IM; Kv7; KCNQ Channels) inhibitor (IC50: 2.4 μM). Linopirdine is a cognitive enhancer. It acts by stimulating rel... | |||
T9009 | ICA-105574 | ICA,3-nitro-N-[4-phenoxyphenyl]-benzamide | HER |
ICA-105574 (ICA) is an activator of hERG that binds to the channel to remove inactivation, thus increasing peak current amplitude and shortening the action potential. It also modulates activation kinetics of the channel. | |||
T7056 | Dronedarone | SR 33589 | P450 , Potassium Channel , Calcium Channel , Sodium Channel , Adrenergic Receptor , AChR , Autophagy |
Dronedarone (SR 33589) is an amiodarone analogue which has an effective and promising treatment for Atrial fibrillation. | |||
T15207 | Eleclazine hydrochloride | GS 6615 hydrochloride | Sodium Channel |
Eleclazine hydrochloride (GS 6615 hydrochloride) is a novel inhibitor of late Na+ current (IC50: 0.7 uM). | |||
T17262 | XE 991 dihydrochloride | Others , Potassium Channel | |
XE 991 dihydrochloride is a Kv7 (KCNQ) channel blocker. XE 991 dihydrochloride potently inhibits Kv7.1 (KCNQ1), Kv7.2 (KCNQ2), Kv7.2 + Kv7.3 (KCNQ3) channel, and M-current (IC50s: 0.75 μM, 0.71 μM, 0.6 μM, and 0.98 μM, r... | |||
TP1858L | Phe-Met-Arg-Phe, amide acetate | Phe-Met-Arg-Phe, amide acetate(64190-70-1 freebase) | Potassium Channel |
Phe-Met-Arg-Phe, amide acetate dose dependently (ED50=23 nM) activates a K+ current in the peptidergic caudodorsal neurons. This peptide appears to localize with neuropeptide Y in some regions of the brain. |