Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Eleclazine hydrochloride (GS 6615 hydrochloride) is a novel inhibitor of late Na+ current (IC50: 0.7 uM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 115.00 | |
5 mg | In stock | $ 247.00 | |
10 mg | In stock | $ 372.00 | |
25 mg | In stock | $ 629.00 | |
50 mg | In stock | $ 896.00 | |
100 mg | In stock | $ 1,220.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 272.00 |
Description | Eleclazine hydrochloride (GS 6615 hydrochloride) is a novel inhibitor of late Na+ current (IC50: 0.7 uM). |
Targets&IC50 | Na+ current:0.7 uM |
In vitro | Inhibition by GS-6615 of ATX-II enhanced late INa is potently correlated with shortening of myocyte APD and isolated heart MAPD[1]. Eleclazine hydrochloride inhibits ATX-II enhanced late INa in ventricular myocytes, shorten the ATX-II induced prolongation of APD, MAPD, QT interval. It also decreased spatiotemporal dispersion of repolarization and ventricular arrhythmias. Selective inhibition of cardiac late INa with eleclazine hydrochloride confers dual protection against vulnerability to ischemia-induced AF. That decreases atrial and ventricular repolarization abnormalities before and during adrenergic stimulation without negative inotropic effects. [2] |
Synonyms | GS 6615 hydrochloride |
Molecular Weight | 451.83 |
Formula | C21H17ClF3N3O3 |
CAS No. | 1448754-43-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (221.32 mM)
You can also refer to dose conversion for different animals. More
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Eleclazine hydrochloride 1448754-43-5 Membrane transporter/Ion channel Sodium Channel Inhibitor Eleclazine GS-6615 GS6615 porcine Eleclazine Hydrochloride KcsA Na+ channels inhibit Na channels epinephrine GS 6615 hydrochloride Potassium Channel GS6615 Hydrochloride GS 6615 Hydrochloride hiPSC atrial premature beats GS 6615 GS-6615 Hydrochloride cardiac arrhythmias inhibitor