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Ibutilide Fumarate

Catalog No. T6541   CAS 122647-32-9
Synonyms: Corvert Fumarate, U70226E

Ibutilide Fumarate (U70226E) is the fumarate salt form of ibutilide, a class III antiarrhythmic agent. Ibutilide exerts its effect by activating a slow, inward, predominately sodium current rather than by blocking outward potassium currents. This results in prolongation of atrial and ventricular action potential duration and refractory periods. Ibutilide slightly decreases the sinus rate and atrioventricular (AV) conduction and produces a dose-related prolongation of the QT interval.

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Ibutilide Fumarate Chemical Structure
Ibutilide Fumarate, CAS 122647-32-9
Pack Size Availability Price/USD Quantity
10 mg In stock $ 50.00
25 mg In stock $ 81.00
50 mg In stock $ 97.00
100 mg In stock $ 179.00
200 mg In stock $ 269.00
1 mL * 10 mM (in DMSO) In stock $ 50.00
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Purity: 99.68%
Purity: 98.91%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Ibutilide Fumarate (U70226E) is the fumarate salt form of ibutilide, a class III antiarrhythmic agent. Ibutilide exerts its effect by activating a slow, inward, predominately sodium current rather than by blocking outward potassium currents. This results in prolongation of atrial and ventricular action potential duration and refractory periods. Ibutilide slightly decreases the sinus rate and atrioventricular (AV) conduction and produces a dose-related prolongation of the QT interval.
Synonyms Corvert Fumarate, U70226E
Molecular Weight 885.23
Formula (C20H36N2O3S)2·C4H4O4
CAS No. 122647-32-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 44.3 mg/mL (100 mM)

DMSO: 44.3 mg/mL (100 mM)

TargetMolReferences and Literature

1. Simon A, et al.Europace. 2016 Mar 22. 2. Ruan L, Quan X, Li L, Bai R, Ni M, Xu R, Zhang C.Exp Ther Med. 2014 May;7(5):1279-1284. Epub 2014 Mar 4. 3. Davies M R, Martinec M, Walls R, et al. Use of Patient Health Records to Quantify Drug-Related Pro-arrhythmic Risk[J]. Cell Reports Medicine. 2020, 1(5): 100076.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Drug Library Anti-Cancer Clinical Compound Library Anti-Cancer Approved Drug Library Anti-COVID-19 Compound Library Ion Channel Inhibitor Library Anti-Cancer Compound Library Clinical Compound Library FDA-Approved & Pharmacopeia Drug Library Calcium Channel Compound Library Anti-Hypertension Compound Library

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Keywords

Ibutilide Fumarate 122647-32-9 Membrane transporter/Ion channel Metabolism Sodium Channel Calcium Channel Ibutilide antiarrhythmia agent Potassium Channel inhibit Corvert Fumarate Inhibitor U70226E long QT syndrome P-glycoprotein K+ current pharmacology KcsA ATP-binding cassette transporters inhibitor

 

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