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GlyH-101

Catalog No. T2451 CAS 328541-79-3

Synonyms: GlyH101, GlyH 101

GlyH-101 is a cell-permeable glycinyl hydrazone compound that blocks CFTR with Ki of 1.4 uM.

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GlyH-101, CAS 328541-79-3

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	GlyH-101 is a cell-permeable glycinyl hydrazone compound that blocks CFTR with Ki of 1.4 uM.
Targets&IC50	CFTR:4.3 μM(Ki)
In vitro	GlyH-101 reversibly inhibits CFTR Cl- conductance in <1 min. [1] In rabbit isolated ventricular myocytes, GlyH-101 also blocks cardiac I(Cl.PKA) channels. [2] In transfected FRT (SLC26A9-FRT) cells, GlyH-101 inhibits SLC26A9-mediated Cl- currents. [3]
In vivo	In mice, Topical GlyH-101 (10 μM) in mice rapidly and reversibly inhibits forskolin-induced hyperpolarization in nasal potential differences. In a cholera model, intraluminal GlyH-101 (2.5 μg) reduces cholera toxin-induced intestinal fluid secretion by approximately 80%.[1]

Synonyms	GlyH101, GlyH 101
Molecular Weight	493.155
Formula	C19H15Br2N3O3
CAS No.	328541-79-3

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 49.3 mg/mL (100 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Muanprasat C, et al. J Gen Physiol. 2004, 124(2), 125-137. 2. Barman PP, et al. Biochem Biophys Res Commun. 2011, 408(1), 12-17. 3. Salomon JJ, et al. Am J Physiol Lung Cell Mol Physiol. 2016. doi: 10.1152/ajplung.200321.2015. 4. Zhang, Yifei, et al. A Membrane Potential- and Calpain-Dependent Reversal of Caspase-1 Inhibition Regulates Canonical NLRP3 Inflammasome [J]. Cell Reports. 2018 Aug 28;24(9):2356-2369.e5.

Citations

1. Zhang Y, Rong H, Zhang F X, et al. A Membrane Potential- and Calpain-Dependent Reversal of Caspase-1 Inhibition Regulates Canonical NLRP3 Inflammasome. Cell Reports. 2018, 24(9): 2356-2369. e5

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Compound Library Autophagy Compound Library Inhibitor Library Ion Channel Inhibitor Library Bioactive Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

GlyH-101 328541-79-3 离子通道自噬 Autophagy CFTR Inhibitor antiproliferative PCT inhibit PS120 cells GlyH101 intestinal fluid GlyH 101 VSORC CFTR-like current Cystic fibrosis transmembrane conductance regulator inhibitor

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