Powder: -20°C for 3 years | In solvent: -80°C for 1 year
NS5806 is an effective potassium current activator. NS5806 slows KV4.3 and KV4.2 current decay in channel complexes containing KChIP2. NS5806 enhances KV4.3/KChIP2 peak current amplitudes (EC50: 5.3 μM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 39.00 | |
5 mg | In stock | $ 97.00 | |
10 mg | In stock | $ 155.00 | |
25 mg | In stock | $ 262.00 | |
50 mg | In stock | $ 389.00 | |
100 mg | In stock | $ 573.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 123.00 |
Description | NS5806 is an effective potassium current activator. NS5806 slows KV4.3 and KV4.2 current decay in channel complexes containing KChIP2. NS5806 enhances KV4.3/KChIP2 peak current amplitudes (EC50: 5.3 μM). |
Targets&IC50 | Kv4.3/KChIP2:5.3 μM |
In vitro | NS5806 activates canine transient outward potassium current (Ito) (IC50: 40.7 nM and an EC50 of 1.6 nM for inhibition and stimulation on the rabbit, respectively). NS5806 (10-100 nM) has concentration-dependent effects on ventricular and atrial Ito. NS5806 (10 μM) induces a 65% increase of KV4.3/KChIP2/DPP6 peak current amplitudes concentration-dependently and the time course of inactivation (τ) is slowed with an EC50 value of 25.4 μM in CHO-K1 cells[1][2]. |
Synonyms | NS-5806 |
Molecular Weight | 574.07 |
Formula | C16H8Br2F6N6O |
CAS No. | 426834-69-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 250 mg/mL (435.49 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
NS5806 426834-69-7 Membrane transporter/Ion channel Potassium Channel KV4.3 Inhibitor KcsA dacay peak NS-5806 KChIP2 NS 5806 Ito KV4.2 current inhibit amplitudes inhibitor