colorectal — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T3055	Liensinine Perchlorate		Apoptosis , Others
	Liensinine is the active constituent of plumula nelambinis with anti-hypertension.		Apoptosis , Others
T9151	Teplinovivint		Wnt/beta-catenin
	Teplinovivint is a potent inhibitor of the Wnt/β-catenin signaling pathway, demonstrating anti-inflammatory properties with potential utility in tendinopathy research.		Wnt/beta-catenin
T9202	DDO-5936		HSP
	DDO-5936 is a potent and specific HSP90-Cdc37 PPI inhibitor.		HSP
T60037	SR15006		DNA/RNA Synthesis
	SR15006 is Krüppel-like factor 5 (KLF5) inhibitor (IC50 = 41.6 nM).		DNA/RNA Synthesis
T9810	TNIK-IN-5		Wnt/beta-catenin
	TNIK-IN-5 is an potent TNIK inhibitor (IC50= 0.05 μM). TNIK-IN-5 potently inhibits Wnt signaling in intact cells. TNIK-IN-5 exhibits excellent in vitro anti-colorectal cancer activity.		Wnt/beta-catenin
T9693	TBAP-001		Raf
	TBAP-001 is a RAF kinase inhibitor, with an IC50 of 62 nM in BRAF V600E kinase assay and an IC50 of 18 nM in Cell-Based Phosho-ERK Assay.		Raf
T9148	KA2507		HDAC
	KA2507 is a potent and selective HDAC6 inibitor with an IC50 of 2.5nM.		HDAC
T9963	MPT0B390		HDAC
	MPT0B390 is an inhibitor of HDAC and a TIMP3 inducer inhibiting tumor growth, metastasis, and angiogenesis.		HDAC
T4985	Neticonazole Hydrochloride		Antifungal
	Neticonazole Hydrochloride is an imidazole antifungal for the treatment of fungal skin infections. Neticonazole is reported as a potent exosome inhibitor which can block the activity of exosomes.		Antifungal
T1867	Otenaproxesul	ATB 346	Apoptosis , COX
	Otenaproxesul (ATB 346) is a novel hydrogen sulphide-releasing derivative of naproxen with markedly reduced toxicity.		Apoptosis , COX
T24437	MCP110	MCP-110,MCP 110	Raf , Ras
	MCP110 is an inhibitor of the interaction of Ras with Raf-1 and can be used in studies about the treatment of human tumors.		Raf , Ras
T11285	FIDAS-5		Others
	FIDAS-5, a potent and orally active methionine S-adenosyltransferase 2A (MAT2A) inhibitor with an IC50 of 2.1 μM, competitively inhibits S-adenosylmethionine (SAM) binding to MAT2A. It exhibits anticancer activities.		Others
T4435	E7820	ER68203-00	Integrin
	E7820 (ER68203-00) is an angiogenesis inhibitor by suppressing integrin a2 (a cell adhesion molecule expressed on endothelial cells).		Integrin
T22318	Taletrectinib	DS-6051b,AB-106	Trk receptor , ROS , ROS Kinase
	Taletrectinib (AB-106) is a new-generation selective inhibitor of ROS1/NTRK including ROS1,NTRK1,NTRK2 and NTRK3 with IC50 of 0.207 nM,0.622 nM,2.28 nM and 0.980 nM, respectively.		Trk receptor , ROS , ROS Kinase
T8545	FEN1-IN-4	FEN1 Inhibitor C2	Others
	FEN1-IN-4 (FEN1 Inhibitor C2) is an inhibitor of human flap endonuclease-1 (hFEN1)		Others
T2301	SB 202190	FHPI,SB202190	Apoptosis , p38 MAPK , Autophagy
	SB 202190 (FHPI) is a p38 MAPK inhibitor that inhibits p38α and p38β2 (IC50=50/100 nM) selectively and cell-permeably. SB 202190 has antitumor activity and also induces the differentiation of human embryonic stem cells i...		Apoptosis , p38 MAPK , Autophagy
T6255	Bromosporine		Epigenetic Reader Domain , CDK
	Bromosporine is a broad spectrum inhibitor for bromodomains for BRD2/4/9 and CECR2 (IC50: 0.41/0.29/0.122/0.017 μM), respectively.		Epigenetic Reader Domain , CDK
T9696	β-catenin-IN-2		Wnt/beta-catenin
	β-catenin-IN-2 is a potent inhibitor of β-catenin that can be used in colorectal cancer research.		Wnt/beta-catenin
TN1305	Ethoxysanguinarine	6-Ethoxydihydrosanguinarine	Apoptosis , AChR
	Ethoxysanguinarine (6-Ethoxydihydrosanguinarine) shows human blood acetylcholinesterase (HuAChE) and human plasma butyrylcholinesterase (HuBuChE) inhibitory activity, with IC50 values of 0.83 +/- 0.04 microM and 4.20 +/-...		Apoptosis , AChR
TN1465	Cannabigerol		NOS , 5-HT Receptor , ROS
	Cannabigerol is a high affinity α±2-adrenergic receptor agonist, moderate affinity 5-HT1A receptor antagonist, and low affinity CB1 receptor antagonist ; also binds to the CB2 receptor; it can relieve interocular pressur...		NOS , 5-HT Receptor , ROS