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KA2507
🥰Excellent
Catalog No. T9148Cas No. 1636894-46-6
KA2507 is a potent and selective HDAC6 inibitor with an IC50 of 2.5nM.
KA2507
🥰Excellent
Purity: 99.03%
Catalog No. T9148Cas No. 1636894-46-6
KA2507 is a potent and selective HDAC6 inibitor with an IC50 of 2.5nM.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $41 | In Stock | |
| 5 mg | $98 | In Stock | |
| 10 mg | $158 | In Stock | |
| 25 mg | $286 | In Stock | |
| 50 mg | $429 | In Stock | |
| 100 mg | $589 | In Stock | |
| 200 mg | $796 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $29 | In Stock |
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Purity:99.03%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | KA2507 is a potent and selective HDAC6 inibitor with an IC50 of 2.5nM. |
| Targets&IC50 | HDAC8:621, HDAC6:2.5nm |
| In vitro | At concentrations selective for HDAC6 inhibition, KA2507 did not inhibit in vitro proliferation of mouse or human cancer cells. |
| In vivo | KA2507 (100-200 mg/kg; p.o.; daily; for 20 days) inhibits tumor growth in the syngeneic B16-F10 mouse melanoma model and shows antitumor efficacy in CT26 and MC38 colorectal cancer models. Tumor sample analysis reveals that at efficacious doses, KA2507 modulates biomarkers of antitumor immunity, resulting in reduced STAT3 activation (measured by phospho-STAT3), decreased PD-L1 expression, and increased MHC class I expression. However, KA2507 exhibits poor oral bioavailability (mice 15%) and Cmax (mice 300 ng/mL) following oral administration (mice 200 mg/kg). [1] |
| Molecular Weight | 322.32 |
| Formula | C16H14N6O2 |
| Cas No. | 1636894-46-6 |
| Smiles | ONC(=O)c1ccc(CN(c2cnccn2)c2cnccn2)cc1 |
| Relative Density. | 1.407 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 60 mg/mL (186.15 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Sci Citations
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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