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KA2507

Name: KA2507
Brand: TargetMol
SKU: T9148
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T9148Cas No. 1636894-46-6

KA2507 is a potent and selective HDAC6 inibitor with an IC50 of 2.5nM.

KA2507

🥰Excellent

Purity: 99.03%

Catalog No. T9148Cas No. 1636894-46-6

KA2507 is a potent and selective HDAC6 inibitor with an IC50 of 2.5nM.

Pack Size	Price	Availability
1 mg	$35	In Stock
5 mg	$81	In Stock
10 mg	$129	In Stock
25 mg	$247	In Stock
50 mg	$372	In Stock
100 mg	$496	In Stock
200 mg	$693	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock

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Batch Information

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Purity:99.03%

Resource Download

COA HPLC HNMR LCMS

Product Introduction

Bioactivity

Description	KA2507 is a potent and selective HDAC6 inibitor with an IC50 of 2.5nM.
Targets&IC50	HDAC6:2.5nm, HDAC8:621
In vitro	At concentrations selective for HDAC6 inhibition, KA2507 did not inhibit in vitro proliferation of mouse or human cancer cells.
In vivo	KA2507 (100-200 mg/kg; p.o.; daily; for 20 days) inhibits tumor growth in the syngeneic B16-F10 mouse melanoma model and shows antitumor efficacy in CT26 and MC38 colorectal cancer models. Tumor sample analysis reveals that at efficacious doses, KA2507 modulates biomarkers of antitumor immunity, resulting in reduced STAT3 activation (measured by phospho-STAT3), decreased PD-L1 expression, and increased MHC class I expression. However, KA2507 exhibits poor oral bioavailability (mice 15%) and Cmax (mice 300 ng/mL) following oral administration (mice 200 mg/kg). [1]

Chemical Properties

Molecular Weight	322.32
Formula	C₁₆H₁₄N₆O₂
Cas No.	1636894-46-6
Smiles	ONC(=O)c1ccc(CN(c2cnccn2)c2cnccn2)cc1
Relative Density.	1.407 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (186.15 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.21 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1025 mL	15.5125 mL	31.0251 mL	155.1253 mL
5 mM	0.6205 mL	3.1025 mL	6.2050 mL	31.0251 mL
10 mM	0.3103 mL	1.5513 mL	3.1025 mL	15.5125 mL
20 mM	0.1551 mL	0.7756 mL	1.5513 mL	7.7563 mL
50 mM	0.0621 mL	0.3103 mL	0.6205 mL	3.1025 mL
100 mM	0.0310 mL	0.1551 mL	0.3103 mL	1.5513 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc