cluster — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T7693	Thiorphan		Neprilysin
	Thiorphan is an neprilysin inhibitor (NEP; IC50 : 0.007 μM).		Neprilysin
T2340	AC1NS4RE		Tyrosinase
	It is a tyrosine kinase inhibitor.		Tyrosinase
T9210	CD73-IN-4		CD73
	CD73-IN-4 is a potent and selective methylenephosphonic acid CD73 inhibitor		CD73
T1176	Racecadotril	Acetorphan	Neprilysin , Proteasome
	Racecadotril (Acetorphan) has been investigated for the basic science and treatment of Diarrhea, Acute Diarrhea, and Acute Gastroenteritis.		Neprilysin , Proteasome
TN1651	Furanodiene		Apoptosis , PARP , Reactive Oxygen Species , Caspase , CDK , P-gp
	Furanodiene has anti-inflammatory and antioxidant activities, it is active against gram-positive bacteria and Candida albicans.
T1938	FLT3-IN-2		FLT
	FLT3-IN-2 is an FLT3 inhibitor (IC50<1 μM).		FLT
T8152	6-Demethoxytangeretin		MAPK , ALK
	6-Demethoxytangeretin is a citrus flavonoid isolated from Citrus depressa.		MAPK , ALK
T4428	CCT241736		FLT , Aurora Kinase
	CCT241736 is an orally bioavailable dual FLT3/Aurora kinase inhibitor that also inhibits clinically relevant FLT3-resistant mutants including FLT3-ITD and FLT3, CCT241736, an advanced analog of CCT137690, is a preclinica...		FLT , Aurora Kinase
T3079	GSK1838705A		IGF-1R , JNK , S6 Kinase , ALK
	GSK1838705A is an effective IGF-1R inhibitor (IC50: 2.0 nM), modestly potent to IR (IC50: 1.6 nM) and ALK (IC50: 0.5 nM), respectively, and little inhibition to other protein kinases.		IGF-1R , JNK , S6 Kinase , ALK
T11298	FLT3-IN-3		FLT
	FLT3-IN-3 is an effective FLT3 inhibitor, and the IC50s of FLT3 WT and FLT3 D835Y are 13 and 8 nM, respectively.		FLT
TQ0106	Sacubitrilat	LBQ-657	Neprilysin
	Sacubitrilat (LBQ-657) (LBQ657) is an effective inhibitor of active neprilysin (NEP).		Neprilysin
T15612	JH-VIII-157-02		Microtubule Associated , ALK
	JH-VIII-157-02 is an inhibitor of ALK and inhibits echinoderm microtubule-associated protein-like 4-ALK (EML4-ALK) with IC50s of 2 nM for EML4-ALK G1202R, EML4-ALKwt, EML4-ALK C1156Y, EML4-ALK F1174L, and EML4-ALK F1174L...		Microtubule Associated , ALK
T2272	BPR1J-097	BPR1J097	FLT
	BPR1J-097) is a novel FLT-3 inhibitor(IC50: 11±7 nM) with promising in vivo anti-tumor activities. It also inhibits FLT-3 D835Y (IC50: 3 nM).		FLT
T15335	FN-1501		FLT , CDK
	FN-1501 is a potent FLT3 and CDK inhibitor (IC50s: 2.47, 0.85, 1.96, and 0.28 nM for CDK2/cyclin A, CDK4/cyclin D1, CDK6/cyclin D1 and FLT3, respectively). FN-1501 also has anticancer activity.		FLT , CDK
T6756	AMG 925		FLT , CDK
	AMG 925 is a potent and orally bioavailable dual FLT3/CDK4 inhibitor with IC50 of 1 nM and 3 nM, respectively.		FLT , CDK
T3S0012	Coniferyl ferulate		P-gp , GST
	Coniferyl ferulate is a strong inhibitor of glutathione S-transferase (GST) isolated from Radix Angelicae sinensis. It shows strong inhibition of human placental GST (IC50: 0.3 μM). It also reverses multidrug resistance ...		P-gp , GST
T2612	CEP-28122		ALK
	CEP-28122 is a highly potent and selective orally active ALK inhibitor.		ALK
T16153	MS4078		ALK , Ligand for E3 Ligase
	MS4078 is an inhibitor and aplastic lymphoma kinase (ALK) PROTAC (degrader) based on Cereblon ligand, with a Kd of 19 nM for binding affinity to ALK.		ALK , Ligand for E3 Ligase
T6138	TCS 359	FLT3 Inhibitor	FLT
	TCS 359 (FLT3 Inhibitor) is a potent FLT3 inhibitor with IC50 of 42 nM.		FLT
T3065	TG101209		Apoptosis , FLT , c-RET , JAK , Autophagy
	TG101209 is a selective JAK2 inhibitor with IC50 of 6 nM.		Apoptosis , FLT , c-RET , JAK , Autophagy