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CCT241736

Catalog No. T4428 CAS 1402709-93-6

CCT241736 is an orally bioavailable dual FLT3/Aurora Kinase inhibitor that also inhibits clinically relevant FLT3-resistant mutants including FLT3-ITD and FLT3, CCT241736, an advanced analog of CCT137690, is a preclinical development candidate for the treatment of human malignancies, and in particular AML in adults and children.

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CCT241736, CAS 1402709-93-6

Pack Size	Availability	Price/USD
5 mg	In stock	$ 55.00
10 mg	In stock	$ 89.00
25 mg	In stock	$ 179.00
50 mg	In stock	$ 347.00
100 mg	In stock	$ 519.00
1 mL * 10 mM (in DMSO)	In stock	$ 61.00

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Purity: 99.88%

Purity: 96.2%

Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	CCT241736 is an orally bioavailable dual FLT3/Aurora kinase inhibitor that also inhibits clinically relevant FLT3-resistant mutants including FLT3-ITD and FLT3, CCT241736, an advanced analog of CCT137690, is a preclinical development candidate for the treatment of human malignancies, and in particular AML in adults and children.
Targets&IC50	FLT3:, Aurora Kinase:
In vivo	UNC2025 was capable of inhibiting Mer phosphorylation in vivo, following oral dosing as demonstrated by pharmaco-dynamic (PD) studies examining phospho-Mer in leukemic blasts from mouse bone marrow.

Molecular Weight	456.37
Formula	C22H23Cl2N7
CAS No.	1402709-93-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 2 years

Solubility Information

DMSO: 75 mg/mL (164.34 mM), Need ultrasonic

H2O: < 0.1 mg/mL (insoluble)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Bavetsias V,etal. Optimization of imidazo[4,5-b]pyridine-based kinase inhibitors: identification of a dual FLT3/Aurora kinase inhibitor as an orally bioavailable preclinical development candidate for the treatment of acute myeloid leukemia.J Med Chem. 2012 Oct 25;55(20):8721-34. 2. Bavetsias V,etal.Aurora Kinase Inhibitors: Current Status and Outlook.Front Oncol. 2015 Dec 21;5:278.

Related compound libraries

This product is contained In the following compound libraries：

Orally Active Compound Library Kinase Inhibitor Library Anti-Aging Compound Library Inhibitor Library Anti-Cancer Compound Library Bioactive Compound Library Bioactive Compounds Library Max Tyrosine Kinase Inhibitor Library NO PAINS Compound Library Anti-Lung Cancer Compound Library

Related Products

Related compounds with same targets

RSH-7 GTP-14564 SKLB 1028 CHMFL-FLT3-122 AXL-IN-13 (3Z)-5-(pyridin-3-yl)-3-[(1H-pyrrol-2-yl)methylidene]-2,3-dihydro-1H-indol-2-one TG-89 JI6

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

CCT241736 1402709-93-6 Angiogenesis Cell Cycle/Checkpoint Chromatin/Epigenetic Tyrosine Kinase/Adaptors FLT Aurora Kinase CCT 241736 Fms like tyrosine kinase 3 CD135 Inhibitor FLT3 CCT-241736 Cluster of differentiation antigen 135 inhibit inhibitor

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