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FN-1501

Catalog No. T15335 CAS 1429515-59-2

FN-1501 is a potent FLT3 and CDK inhibitor (IC50s: 2.47, 0.85, 1.96, and 0.28 nM for CDK2/cyclin A, CDK4/cyclin D1, CDK6/cyclin D1 and FLT3, respectively). FN-1501 also has anticancer activity.

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FN-1501, CAS 1429515-59-2

Pack Size	Availability	Price/USD
1 mg	In stock	$ 84.00
5 mg	In stock	$ 197.00
10 mg	In stock	$ 372.00
25 mg	In stock	$ 629.00
50 mg	In stock	$ 896.00
100 mg	In stock	$ 1,220.00
1 mL * 10 mM (in DMSO)	In stock	$ 226.00

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Purity: 96.35%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	FN-1501 is a potent FLT3 and CDK inhibitor (IC50s: 2.47, 0.85, 1.96, and 0.28 nM for CDK2/cyclin A, CDK4/cyclin D1, CDK6/cyclin D1 and FLT3, respectively). FN-1501 also has anticancer activity.
Targets&IC50	FLT3:0.28 nM, CDK2-CyclinA:2.47 nM, CDK6-CyclinD1:1.96 nM, CDK4-CyclinD1:0.85 nM
In vitro	FN-1501 displays potent inhibitory activity against several tumor cells, such as MGC803, RS4;11, MCF-7, HCT-116, and NCI-H82 (GI50s of 0.37 ± 0.04, 0.05 ± 0.01, 2.84 ± 0.25, 0.09 ± 0.04, 0.11 ± 0.02 nM, respectively)[1].
In vivo	FN-1501 shows potent antitumor activity and it also shows little cytotoxicity on normal lymphocyte cells (LD50: 185.67 mg/kg in ICR mice). FN-1501 (15. 30, or 40 mg/kg/d, i.v.) dose-dependently and obviously inhibits the growth of tumors in MV4-11-cell-inoculated-xenograft mice[1].

Molecular Weight	431.49
Formula	C22H25N9O
CAS No.	1429515-59-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 45 mg/mL (104.29 mM)

References and Literature

1. Wang Y, et al. Discovery of 4-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-N-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-1H-pyrazole-3-carboxamide (FN-1501), an FLT3- and CDK-Kinase Inhibitor with Potentially High Efficiency against Acute Myelocytic Leukemia. J Med Chem. 2018 Feb 22;61(4):1499-1518.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Kinase Inhibitor Library Anti-Cancer Drug Library Anti-Cancer Active Compound Library Tyrosine Kinase Inhibitor Library Drug Repurposing Compound Library Anti-Cancer Clinical Compound Library Anti-Breast Cancer Compound Library Anti-Pancreatic Cancer Compound Library Bioactive Compounds Library Max

Related Products

Related compounds with same targets

Brigatinib BRD7389 Tesevatinib Tyrosine kinase-IN-1 Altiratinib Ripretinib UNC2541 BMS-2

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Keywords

FN-1501 1429515-59-2 Angiogenesis Cell Cycle/Checkpoint Tyrosine Kinase/Adaptors FLT CDK FLT3 Fms like tyrosine kinase 3 Cluster of differentiation antigen 135 CD135 Cyclin dependent kinase FN1501 inhibit Inhibitor FN 1501 inhibitor

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