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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
TN1417 | Azadirachtin | Apoptosis , Antifection | |
Azadirachtin has antifungal activity, used as an insecticide. | |||
T15485 | HJC0197 | cAMP , Ras | |
HJC0197 selectively blocks cAMP-induced Epac activation. HJC0197 is an effective exchange protein. Which straightly activated by cAMP (Epac) antagonist (IC50=5.9 μM for Epac2). | |||
T27478 | GSK3987 | Liver X Receptor | |
GSK3987 is an LXR ligand. GSK3987 recruits the steroid receptor coactivator-1 to human LXRalpha and LXRbeta with EC50s of 40 nM. | |||
T1855 | ZCL278 | ZCL 278 | CDK , Ras |
ZCL278 is a selective Cdc42 GTPase inhibitor. | |||
T14496 | BAMB-4 | ITPKA-IN-C14 | Others |
BAMB-4 (ITPKA-IN-C14) is a highly membrane-permeable inhibitor of inositol-1,4,5-trisphosphate-3-kinase A (ITPKA). It acts by suppressing the metastasis-promoting effect of ITPKA in lung tumor cells(with IC50 of 37 μM in... | |||
T8693 | Diallyl Trisulfide | Apoptosis , Reactive Oxygen Species , Antifungal | |
Diallyl Trisulfide is an organic polysulfide compound found in garlic that acts as an H2S donor. | |||
T5329 | Trandolapril | Angiotensin-converting Enzyme (ACE) | |
Trandolapril is an orally administered angiotensin converting enzyme (ACE) inhibitor that is hydrolysed to the active diacid trandolaprilat. | |||
T9352 | Hydrocotarnine | Others | |
hydrocotarnine is an inhibitor of Cbl. | |||
T23450 | TCS PrP Inhibitor 13 | 5-(4-Nitrophenyl)-2-Phenyl-4H-Pyrazol-3-One | Others |
TCS PrP Inhibitor 13 (5-(4-Nitrophenyl)-2-Phenyl-4H-Pyrazol-3-One) is an antiprion agent inhibiting protease-resistant prion protein (PrP-res) accumulation. | |||
T36523 | Extracellular Death Factor | ||
Programmed cell death in bacteria is dependent on a system of cell-to-cell communication termed quorum sensing. Extracellular death factor (EDF) is a linear pentapeptide that communicating cells produce and release, whic... | |||
T12302 | OMDM-1 | (Z)-N-[(2S)-1-hydroxy-3-(4-hydroxyphenyl)propan-2-yl]octadec-9-enamide | Endogenous Metabolite |
OMDM-1 ((Z)-N-[(2S)-1-hydroxy-3-(4-hydroxyphenyl)propan-2-yl]octadec-9-enamide) is a selective and metabolically stable anandamide cellular uptake (ACU)inhibitor with a Ki of 2.4 μM. | |||
T12236 | NMS-859 | ZINC169324353 | Others |
NMS-859 is an effective and covalent inhibitor of valosin-containing protein (VCP)/p97 with IC50s of 0.37 μM and 0.36 μM for wild-type VCP in the presence of 60 μM and 1 mM ATP in cells, respectively. | |||
T12307 | OMDM-6 | Cannabinoid Receptor , Endogenous Metabolite , TRP/TRPV Channel | |
OMDM-6 is a dual agonist of TRPV1(EC50 = 75 nM) and CB1 (Ki = 3.2 μM). OMDM-6 inhibits anandamide cellular uptake with a Ki of 7.0 μM. | |||
T17180 | TVB-3166 | Apoptosis , Others , Fatty Acid Synthase | |
TVB-3166 induces apoptosis and inhibits in-vivo xenograft tumor growth. TVB-3166 is a reversible and selective fatty acid synthase inhibitor (IC50s: 42 nM and 81 nM for biochemical FASN and cellular palmitate synthesis,... | |||
T11374 | GCN2-IN-6 | Others , PERK | |
GCN2-IN-6 is also a eIF2α kinase PERK inhibitor with an IC50 of 0.26 nM (in enzymatic assay) and 230 nM (in cells). GCN2-IN-6 is a potent, and orally available GCN2 inhibitor confirmed by in-house enzymatic (IC50 of 1.8... | |||
T40220L | TRV055 acetate | TRV055 acetate (25849-90-5 Free base) | RAAS |
TRV055 acetate is a ligand of angiotensin II type 1 receptor and stimulates cellular Gq-mediated signaling. | |||
T13423L | (1S,2R)-2-PCCA | (1S,2R)-2-PCCA(Iso-1609563-71-4) | GPR |
(1S,2R)-2-PCCA is a novel and potent small molecule GPR88 receptor agonist with an EC50 value of 3 nM in the non-cellular system and 603 nM in the cellular system. | |||
T27812 | Leminoprazole | ATPase | |
Leminoprazole is an orally available H+,K(+)-ATPase inhibitor that protects gastric mucosal cells from various cellular damages. | |||
T3768 | Epifriedelanol | Epifriedelinol | Others |
Epifriedelanol (Epifriedelinol) suppresses adriamycin-induced cellular senescence, replicative senescence in human fibroblasts (HDFs) and HUVECs. Because of Epifriedelanol can reduce cellular senescence in human primary ... | |||
T6859 | I-BRD9 | GSK602 | Epigenetic Reader Domain |
I-BRD9 (GSK602) is the first selective cellular inhibitor for BRD9 with pIC50 of 7.3. |