Powder: -20°C for 3 years | In solvent: -80°C for 1 year
NMS-859 is an effective and covalent inhibitor of valosin-containing protein (VCP)/p97 with IC50s of 0.37 μM and 0.36 μM for wild-type VCP in the presence of 60 μM and 1 mM ATP in cells, respectively.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 163.00 | |
2 mg | In stock | $ 227.00 | |
5 mg | In stock | $ 347.00 | |
10 mg | In stock | $ 497.00 | |
25 mg | In stock | $ 793.00 | |
50 mg | In stock | $ 1,130.00 | |
100 mg | In stock | $ 1,520.00 | |
500 mg | In stock | $ 2,970.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 382.00 |
Description | NMS-859 is an effective and covalent inhibitor of valosin-containing protein (VCP)/p97 with IC50s of 0.37 μM and 0.36 μM for wild-type VCP in the presence of 60 μM and 1 mM ATP in cells, respectively. |
Targets&IC50 | Cellular p97 (60 μM ATP):370 nM , Cellular p97 (1 mM ATP):360 nM |
In vitro | NMS-859 suppresses the cell proliferation with IC50s of 3.0 μM and 3.5 μM in HeLa and HCT116 cell lines, respectively. NMS-859 shows weak inhibitory activity against VCPC522T[1]. |
Synonyms | ZINC169324353 |
Molecular Weight | 349.79 |
Formula | C15H12ClN3O3S |
CAS No. | 1449236-96-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 35 mg/mL (100.1 mM)
You can also refer to dose conversion for different animals. More
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NMS-859 1449236-96-7 Others ZINC-169324353 NMS859 ZINC 169324353 NMS 859 ZINC169324353 inhibitor inhibit