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Search Results for " cancer chemotherapy "

20

Compounds

Cat No. Product Name Synonyms Targets
T2747 Endothall Phosphatase , Others
Endothall is a protein phosphatase 2A (PP2A) inhibitor, capable of inhibiting PP2A (IC50: 90 nM) and PP1 (IC50: 5 uM). It acts as a herbicide and can also be useful in cancer chemotherapy.
T9271 RAD51-IN-1 DNA/RNA Synthesis
Rad51-in-1 is a derivative of B02 and an effective inhibitor of Rad51.
T2217 Cephalomannine Baccatin III Microtubule Associated
Cephalomannine (Baccatin III) is a taxol derivative obtained from Taxus yunnanensis with antitumor activity.
T0132 Etoposide VP-16,VP-16-213 Apoptosis , Mitophagy , Topoisomerase , Antibacterial , Antibiotic , Autophagy
Etoposide (VP-16-213) is a topoisomerase II inhibitor that inhibits DNA synthesis by forming a complex with topoisomerase II and DNA (IC50=60.3 μM). Etoposide has antitumor activity and induces apoptosis and autophagy.
T1478 Ondansetron hydrochloride dihydrate SN 307,NSC 665799,GR 38032,Ondansetron hydrochloride 5-HT Receptor
Ondansetron hydrochloride dihydrate (GR 38032) is a competitive serotonin type 3 receptor antagonist. It is effective in the treatment of nausea and vomiting caused by cytotoxic chemotherapy drugs, including cisplatin, a...
T2047 AG-1478 AG1478,NSC 693255,Tyrphostin AG-1478 EGFR , HCV Protease , Influenza Virus , HER , PDGFR
AG-1478 (NSC-693255) (Tyrphostin AG-1478) is a selective EGFR inhibitor.
T16871 Semustine DNA Alkylator/Crosslinker
Semustine, a DNA alkylating agent, is a cancer chemotherapy compound that is nephrotoxic in patients with malignant melanoma receiving adjuvant chemotherapy for the adjuvant treatment of leukemia.
T6431 Levoleucovorin Calcium Calcium Levofolinate,CL307782 Others , Antifolate
Levoleucovorin Calcium (CL307782), a calcium salt of the folinic acid, is used in cancer chemotherapy as an adjuvant.
T28187 Nonabine Others
Nonabine is a compound with strong antiemetic properties that can be used to prevent nausea and vomiting associated with cancer chemotherapy.
T1755 LY2090314 GSK-3
LY2090314, an effective GSK-3α/β inhibitor (IC50: 1.5 nM/0.9 nM), may improve the efficacy of platinum-based chemotherapy regimens. LY2090314 has been used in trials studying the treatment of Leukemia, Advanced Cancer, a...
T6616 Ondansetron hydrochloride SN 307,Ondansetron HCl,Emeset,GR 38032 HCl,NSC 665799,Zofran 5-HT Receptor
Ondansetron hydrochloride (Zofran) is a serotonin 5-HT3 receptor antagonist, used to prevent nausea and vomiting caused by cancer chemotherapy, and radiation therapy.
T1042 Granisetron hydrochloride BRL 43694A,Granisetron HCl 5-HT Receptor
Granisetron hydrochloride (Granisetron HCl) is a serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic for cancer chemotherapy patients.
T24184 Itasetron DAU6215CL,UNII-00S0D0OEKR,U-98079A,U 98079A,DAU 6215CL 5-HT Receptor
Itasetron (U 98079A) is a 5-hydroxytryptamine 3-receptor antagonist used to prevent age-related memory deficits in rats.Itasetron's antiemetic activity in animal models of cancer chemotherapy and radiation therapy may be...
T21876 DC_AC50 Apoptosis , Others
DC_AC50 is a dual inhibitor of Atox1 and CCS (copper chaperones). Inhibiting intracellular copper chaperones as a means of reducing/preventing acquired chemotherapy resistance.DC_AC50 binding to Atox1 and CCS and reducin...
T3924 Astragaloside II Astrasieversianin VIII TGF-beta/Smad
Astragaloside II (Astrasieversianin VIII) is an effective MDR reversal agent and may be a potential adjunctive agent for hepatic cancer chemotherapy. Astragaloside II also induces osteogenic activities, differentiation, ...
T28935 TDRL-551 Others
TDRL-551 is a novel and potent replication protein A (RPA) inhibitor (IC50=18 µM) with potential anticancer activity.TDRL-551 inhibits RPA-DNA interaction and enhances the efficacy of platinum-based chemotherapy for lung...
T4451 Estramustine phosphate sodium Ro 21-8837/001,Estramustine phosphate disodium Apoptosis , Microtubule Associated
Estramustine phosphate sodium (Ro 21-8837/001) is an antimicrotubule chemotherapy agent; arrests prostate cancer cells in the G2/M phase of the cell cycle.
T6127 Rucaparib Phosphate AG-014699 phosphate,PF-01367338,AG-014699,PF-01367338 phosphate PARP
Rucaparib Phosphate (PF-01367338 phosphate) is an inhibitor of PARP (Ki: 1.4 nM for PARP1) that is used in clinical therapy to sensitize cancer cells to chemotherapy.
T39024 PrNMI Cannabinoid Receptor
PrNMI is a highly effective and orally active agonist targeting the peripherally restricted cannabinoid 1 receptor (CB1R). It exhibits pronounced analgesic properties, efficiently suppressing both chemotherapy-induced pe...
T3716 Rolapitant SCH619734 Neurokinin receptor
Rolapitant (SCH619734) Hydrochloride is the hydrochloride salt form of rolapitant, an orally bioavailable, centrally-acting, selective, neurokinin 1 receptor (NK1-receptor) antagonist with potential antiemetic activity. ...

Compounds

Endothall
T2747
Synonym:
Target: Phosphatase, Others
RAD51-IN-1
T9271
Synonym:
Target: DNA/RNA Synthesis
Cephalomannine
T2217
Synonym: Baccatin III
Target: Microtubule Associated
Etoposide
T0132
Synonym: VP-16,VP-16-213
Target: Apoptosis, Mitophagy, Topoisomerase, Antibacterial, Antibiotic, Autophagy
Ondansetron hydrochloride dihydrate
T1478
Synonym: SN 307,NSC 665799,GR 38032,Ondansetron hydrochloride
Target: 5-HT Receptor
AG-1478
T2047
Synonym: AG1478,NSC 693255,Tyrphostin AG-1478
Target: EGFR, HCV Protease, Influenza Virus, HER, PDGFR
Semustine
T16871
Synonym:
Target: DNA Alkylator/Crosslinker
Levoleucovorin Calcium
T6431
Synonym: Calcium Levofolinate,CL307782
Target: Others, Antifolate
Nonabine
T28187
Synonym:
Target: Others
LY2090314
T1755
Synonym:
Target: GSK-3
Ondansetron hydrochloride
T6616
Synonym: SN 307,Ondansetron HCl,Emeset,GR 38032 HCl,NSC 665799,Zofran
Target: 5-HT Receptor
Granisetron hydrochloride
T1042
Synonym: BRL 43694A,Granisetron HCl
Target: 5-HT Receptor
Itasetron
T24184
Synonym: DAU6215CL,UNII-00S0D0OEKR,U-98079A,U 98079A,DAU 6215CL
Target: 5-HT Receptor
DC_AC50
T21876
Synonym:
Target: Apoptosis, Others
Astragaloside II
T3924
Synonym: Astrasieversianin VIII
Target: TGF-beta/Smad
TDRL-551
T28935
Synonym:
Target: Others
Estramustine phosphate sodium
T4451
Synonym: Ro 21-8837/001,Estramustine phosphate disodium
Target: Apoptosis, Microtubule Associated
Rucaparib Phosphate
T6127
Synonym: AG-014699 phosphate,PF-01367338,AG-014699,PF-01367338 phosphate
Target: PARP
PrNMI
T39024
Synonym:
Target: Cannabinoid Receptor
Rolapitant
T3716
Synonym: SCH619734
Target: Neurokinin receptor
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TargetMol